Entry |
|
Name |
Ritonavir (JAN/USP/INN); Norvir (TN) |
Abbr |
RTV, r |
Product |
|
Generic |
|
Formula |
C37H48N6O5S2
|
Exact mass |
720.3128
|
Mol weight |
720.95
|
Structure |

|
Simcomp |
|
Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Metabolizing enzyme inducer
DG01637 CYP1A2 inducer
DG02886 CYP2C9 inducer
DG02885 CYP2C19 inducer
|
Remark |
Therapeutic category: | 6250 |
Product (mixture): | D02498<JP/US> D12269<JP/US> |
|
Efficacy |
Antiviral, HIV protease inhibitor |
Disease |
|
Target |
|
Pathway |
ko03260 | Virion - Human immunodeficiency virus |
|
Metabolism |
|
Interaction |
CYP induction: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557]
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
|
Structure map |
|
Other map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE03 Ritonavir
D00427 Ritonavir (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors (PI)
Ritonavir
D00427 Ritonavir (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D00427 Ritonavir (JAN/USP/INN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
D00427 Ritonavir
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D00427 Ritonavir
DG01633 CYP3A/CYP3A4 substrate
D00427 Ritonavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
D00427 Ritonavir
Metabolizing enzyme inducer
DG01637 CYP1A2 inducer
D00427 Ritonavir
DG02886 CYP2C9 inducer
D00427 Ritonavir
DG02885 CYP2C19 inducer
D00427 Ritonavir
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D00427 Ritonavir
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D00427 Ritonavir (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D00427 Ritonavir (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00427
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00427
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 50
1 C1c C 33.1164 -17.1963
2 C1b C 33.1237 -18.5903
3 C1b C 34.3298 -16.5030
4 N1b N 31.9103 -16.5103
5 C8y C 34.1059 -19.5798
6 C1c C 35.5358 -17.1892
7 C5a C 30.7041 -17.2037
8 C8x C 33.3982 -20.7786
9 C8x C 35.4926 -19.5868
10 C1c C 36.7348 -16.4960
11 O1a O 35.5431 -18.5831
12 C1c C 29.4983 -16.5175
13 O5a O 30.7041 -18.5975
14 C8x C 34.0915 -21.9846
15 C8x C 36.1859 -20.7931
16 C1b C 36.7348 -15.0948
17 N1b N 37.9408 -17.1819
18 N1b N 28.2849 -17.2108
19 C1c C 29.4909 -14.6983
20 C8x C 35.4782 -21.9919
21 C8y C 35.5212 -14.3942
22 C7a C 39.1540 -16.4886
23 C5a C 27.0787 -16.5247
24 C1a C 30.7041 -13.9977
25 C1a C 28.2776 -13.9977
26 C8x C 35.5212 -13.0004
27 C8x C 34.3225 -15.1019
28 O7a O 40.3603 -17.1748
29 O6a O 39.1465 -15.0875
30 N1c N 25.8799 -17.2181
31 O5a O 27.0787 -15.1237
32 C8x C 34.3153 -12.3071
33 C8x C 33.1092 -14.4013
34 C1b C 41.5663 -16.4815
35 C1b C 24.6737 -16.5321
36 C1a C 25.8799 -18.6120
37 C8x C 33.1092 -13.0075
38 C8y C 42.7723 -17.1675
39 C8y C 23.4604 -17.2252
40 C8x C 42.7653 -18.5615
41 S2x S 44.1013 -16.7485
42 N5x N 22.1171 -16.8642
43 C8x C 23.4626 -18.6191
44 N5x N 44.0868 -18.9947
45 C8x C 44.9100 -17.8754
46 C8y C 21.3445 -18.0341
47 S2x S 22.2256 -19.1175
48 C1c C 19.9506 -18.0296
49 C1a C 19.1994 -16.8594
50 C1a C 19.3149 -19.2789
BOND 53
1 1 2 1 #Down
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1 #Up
11 7 12 1
12 7 13 2
13 8 14 1
14 9 15 2
15 10 16 1 #Down
16 10 17 1
17 12 18 1
18 12 19 1 #Up
19 14 20 2
20 16 21 1
21 17 22 1
22 18 23 1
23 19 24 1
24 19 25 1
25 21 26 2
26 21 27 1
27 22 28 1
28 22 29 2
29 23 30 1
30 23 31 2
31 26 32 1
32 27 33 2
33 28 34 1
34 30 35 1
35 30 36 1
36 32 37 2
37 34 38 1
38 35 39 1
39 38 40 2
40 38 41 1
41 39 42 1
42 39 43 2
43 40 44 1
44 41 45 1
45 42 46 2
46 43 47 1
47 46 48 1
48 48 49 1
49 48 50 1
50 15 20 1
51 33 37 1
52 44 45 2
53 46 47 1
|