KEGG   DRUG: Meclofenamic acid
Entry
D02341                      Drug                                   
Name
Meclofenamic acid (USAN/INN)
Formula
C14H11Cl2NO2
Exact mass
295.0167
Mol weight
296.1486
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01911  Anti-inflammatory drug, fenamic acid derivatives
Remark
Same as: C07117
ATC code: M01AG04 M02AA18
Chemical structure group: DG00758
Product (DG00758): D00169<US>
Efficacy
Anti-inflammatory, COX inhibitor
Comment
Fenamic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG04 Meclofenamic acid
      D02341  Meclofenamic acid (USAN/INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA18 Meclofenamic acid
      D02341  Meclofenamic acid (USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00758  Meclofenamic acid
     D02341  Meclofenamic acid
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D02341  Meclofenamic acid (USAN/INN)
    PTGS2 (COX2)
     D02341  Meclofenamic acid (USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00758  Meclofenamic acid
Other DBs
CAS: 644-62-2
PubChem: 7849400
ChEBI: 6710
PDB-CCD: JMS[PDBj]
LigandBox: D02341
NIKKAJI: J7.065C
LinkDB
KCF data

ATOM        19
            1   C8y C    22.8900  -21.9800
            2   N1b N    21.7000  -21.2800
            3   C8y C    24.0800  -21.2800
            4   C8y C    22.8900  -23.3800
            5   C8y C    20.4400  -21.9800
            6   C8y C    25.3400  -21.9800
            7   X   Cl   24.0800  -19.8800
            8   C8x C    24.0800  -24.0800
            9   X   Cl   21.7000  -24.0800
            10  C8y C    19.2500  -21.2800
            11  C8x C    20.4400  -23.3800
            12  C8x C    25.3400  -23.3800
            13  C1a C    26.5300  -21.2800
            14  C8x C    17.9900  -21.9800
            15  C6a C    19.2500  -19.8800
            16  C8x C    19.2500  -24.0800
            17  C8x C    17.9900  -23.3800
            18  O6a O    18.0600  -19.2500
            19  O6a O    20.4400  -19.1800
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 2
            16   14  17 2
            17   15  18 1
            18   15  19 2
            19    8  12 2
            20   16  17 1

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KEGG   DRUG: Meclofenamate sodium
Entry
D00169                      Drug                                   
Name
Meclofenamate sodium (USP);
Meclofenamate sodium monohydrate;
Meclomen (TN)
Product
  Generic
Formula
C14H10Cl2NO2. Na. H2O
Exact mass
335.0092
Mol weight
336.1457
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01911  Anti-inflammatory drug, fenamic acid derivatives
Remark
ATC code: M01AG04 M02AA18
Chemical structure group: DG00758
Product (DG00758): D00169<US>
Efficacy
Anti-inflammatory, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Comment
Fenamic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG04 Meclofenamic acid
      D00169  Meclofenamate sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA18 Meclofenamic acid
      D00169  Meclofenamate sodium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Meclofenamate
    D00169  Meclofenamate sodium (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00758  Meclofenamic acid
     D00169  Meclofenamate sodium
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00169  Meclofenamate sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00169  Meclofenamate sodium (USP) <US>
    PTGS2 (COX2)
     D00169  Meclofenamate sodium (USP) <US>
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00758  Meclofenamic acid
Other DBs
PubChem: 7847237
ChEBI: 76232
LigandBox: D00169
LinkDB
KCF data

ATOM        21
            1   C8y C    25.5707  -19.5008
            2   N1b N    24.3588  -18.8040
            3   C8y C    26.7826  -18.8040
            4   C8y C    25.5648  -20.9000
            5   C8y C    23.1469  -19.5008
            6   C8y C    27.9945  -19.5008
            7   X   Cl   26.7767  -17.3989
            8   C8x C    26.7767  -21.6025
            9   X   Cl   24.3529  -21.5966
            10  C8y C    21.9350  -18.7982
            11  C8x C    23.1469  -20.9000
            12  C8x C    27.9945  -20.9057
            13  C1a C    29.2064  -18.8040
            14  C8x C    20.7232  -19.5008
            15  C6a C    21.9410  -17.3989
            16  C8x C    21.9350  -21.6025
            17  C8x C    20.7232  -20.9000
            18  O6a O    20.7291  -16.6964
            19  O6a O    23.1529  -16.7023 #-
            20  Z   Na   24.7552  -16.5141 #+
            21  O0  O    30.6600  -20.8600
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 2
            16   14  17 2
            17   15  18 2
            18   15  19 1
            19    8  12 2
            20   16  17 1

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