Entry |
|
Name |
Rifaximin (JAN/USAN/INN); Xifaxan (TN) |
Product |
|
Formula |
C43H51N3O11
|
Exact mass |
785.3524
|
Mol weight |
785.8785
|
Structure |

|
Simcomp |
|
Class |
|
Remark |
Therapeutic category: | 6199 |
|
Efficacy |
Antibacterial, Antihyperammonemic |
Disease |
Hepatic encephalopathy [DS: H01506] |
Comment |
Rifamycin derivative
|
Target |
DNA-directed RNA polymerase subunit beta [KO: K03043] |
Pathway |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
Transporter: ABCB1 [HSA: 5243], SLCO1A2 [HSA: 6579], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
|
Interaction |
CYP induction: CYP3A4 [HSA: 1576]
Transporter inhibition: ABCB1 [HSA: 5243], SLCO1A2 [HSA: 6579], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA11 Rifaximin
D02554 Rifaximin (JAN/USAN/INN) <JP/US>
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06A ANTIBIOTICS FOR TOPICAL USE
D06AX Other antibiotics for topical use
D06AX11 Rifaximin
D02554 Rifaximin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Rifaximin
D02554 Rifaximin (JAN/USAN/INN)
Gastrointestinal Agents
Anti-Diarrheal Agents
Rifaximin
D02554 Rifaximin (JAN/USAN/INN)
Gastrointestinal Agents, Other
Rifaximin
D02554 Rifaximin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
619 Miscellaneous
6199 Miscellaneous
D02554 Rifaximin (JAN/USAN/INN)
Antiinfectives [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D02554 Rifaximin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02554
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02554
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02554
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02554
Drug transporters
D02554
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Other DBs |
|
LinkDB |
|
KCF data |
ATOM 57
1 C1c C 32.1192 -10.8276
2 C1c C 32.1192 -12.2327
3 O1a O 34.4611 -12.1658
4 C1c C 34.4611 -10.8276
5 C1c C 33.2567 -10.1584
6 C2b C 36.7362 -10.8276
7 C1c C 35.5987 -10.1584
8 C5a C 37.9406 -12.9019
9 C2c C 39.0781 -12.2327
10 C2b C 39.0781 -10.8276
11 C2b C 37.9406 -10.1584
12 C1a C 35.5987 -8.8202
13 C1a C 33.2567 -8.8202
14 O1a O 30.9817 -10.1584
15 C1a C 40.2157 -12.9019
16 O5a O 36.8031 -12.2327
17 N1b N 37.9406 -14.5078
18 C1c C 30.9817 -12.9019
19 O7a O 29.8441 -12.2327
20 C1c C 30.9817 -14.5078
21 C8y C 36.8031 -15.1769
22 C8y C 36.8031 -16.5152
23 C8y C 35.5987 -14.5078
24 C8y C 34.4611 -15.1769
25 C8y C 34.4611 -16.5152
26 C8y C 35.5987 -17.1843
27 C8y C 33.3236 -14.5078
28 C8y C 32.1192 -15.1769
29 C8y C 32.1192 -16.5152
30 C8y C 33.3236 -17.1843
31 O1a O 35.5987 -13.1695
32 O1a O 33.3236 -13.1695
33 C1a C 30.9817 -11.1621
34 C7a C 28.6397 -11.5636
35 C1a C 27.5022 -12.2327
36 O6a O 28.6397 -10.2253
37 C1c C 29.8441 -15.1769
38 O2a O 28.7066 -14.5078
39 C2b C 29.8441 -16.5152
40 C1a C 29.8441 -13.5710
41 C1a C 27.5691 -15.1769
42 C2b C 28.7066 -17.1843
43 O2a O 28.7066 -18.5226
44 O2x O 30.9817 -17.1843
45 C1z C 30.9817 -18.5226
46 C5x C 33.3236 -18.5226
47 C1a C 30.9817 -19.8608
48 C1a C 32.1192 -13.8387
49 N5x N 35.5987 -18.5226
50 C8y C 37.9406 -18.5226
51 N4y N 37.9406 -17.1843
52 O5x O 34.3942 -19.1917
53 C8x C 39.1530 -19.2226
54 C8y C 40.3655 -18.5226
55 C8x C 40.3655 -17.1843
56 C8x C 39.1530 -16.4843
57 C1a C 41.6083 -19.2398
BOND 62
1 1 2 1
2 4 3 1 #Down
3 4 5 1
4 1 5 1
5 6 7 1
6 4 7 1
7 8 9 1
8 9 10 2
9 10 11 1
10 6 11 2
11 7 12 1 #Up
12 5 13 1 #Down
13 1 14 1 #Down
14 9 15 1
15 8 16 2
16 8 17 1
17 2 18 1
18 18 19 1 #Up
19 18 20 1
20 17 21 1
21 21 22 1
22 21 23 2
23 23 24 1
24 24 25 1
25 25 26 1
26 24 27 2
27 27 28 1
28 28 29 2
29 29 30 1
30 25 30 2
31 23 31 1
32 27 32 1
33 2 33 1 #Up
34 19 34 1
35 34 35 1
36 34 36 2
37 26 22 2
38 20 37 1
39 37 38 1 #Down
40 37 39 1
41 20 40 1 #Down
42 38 41 1
43 39 42 2
44 42 43 1
45 29 44 1
46 44 45 1
47 43 45 1
48 30 46 1
49 45 46 1
50 45 47 1 #Down
51 28 48 1
52 26 49 1
53 50 51 1
54 22 51 1
55 52 46 2
56 49 50 2
57 50 53 1
58 53 54 2
59 54 55 1
60 55 56 2
61 51 56 1
62 54 57 1
|