| Entry |
|
|---|
| Name |
Moclobemide (USAN/INN);
Aurorix (TN) |
|---|
| Formula |
C13H17ClN2O2
|
|---|
| Exact mass |
268.0979
|
|---|
| Mol weight |
268.74
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01558 Monoamine oxidase A inhibitor
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidepressant, Monoamine oxidase A (MAO-A) inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00330 | Arginine and proline metabolism |
| hsa00982 | Drug metabolism - cytochrome P450 |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565], CYP2C19 [HSA: 1557]
|
|---|
| Structure map |
| map07216 | Catecholamine transferase inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AG Monoamine oxidase A inhibitors
N06AG02 Moclobemide
D02561 Moclobemide (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01558 Monoamine oxidase A inhibitor
D02561 Moclobemide
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D02561 Moclobemide
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
D02561 Moclobemide
DG01645 CYP2D6 inhibitor
D02561 Moclobemide
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Amine oxidases
MAOA
D02561 Moclobemide (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02561
|
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| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 18
1 C8x C 11.9700 -17.9200
2 C8y C 11.9700 -19.3200
3 C8x C 13.1824 -20.0200
4 C8x C 14.3949 -19.3200
5 C8y C 14.3949 -17.9200
6 C8x C 13.1824 -17.2200
7 X Cl 10.7576 -20.0200
8 C5a C 15.6260 -17.2090
9 N1b N 16.8312 -17.9047
10 O5a O 15.6257 -15.8201
11 C1b C 18.0135 -17.2219
12 C1b C 19.2075 -17.9112
13 N1y N 20.3954 -17.2252
14 C1x C 21.5865 -17.9129
15 C1x C 22.7990 -17.2129
16 O2x O 22.7990 -15.8129
17 C1x C 21.6079 -15.1252
18 C1x C 20.3955 -15.8252
BOND 19
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 2 7 1
8 5 8 1
9 8 9 1
10 8 10 2
11 9 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 15 16 1
17 16 17 1
18 17 18 1
19 13 18 1
|
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