KEGG   DRUG: TocilizumabHelp
Entry
D02596                      Drug                                   

Name
Tocilizumab (USAN/INN);
Tocilizumab (genetical recombination) (JAN);
Actemra (TN)
Product
Formula
C6428H9976N1720O2018S42
Exact mass
144895.9145
Mol weight
144985.0322
Class
Other
 DG02019  Interleukin inhibitor
Remark
Therapeutic category: 6399
ATC code: L04AC07
Product: D02596<JP/US>
Efficacy
Anti-inflammatory, Antirheumatic, Immunosuppressant, Anti-IL-6 receptor antibody
  Disease
Rheumatoid arthritis [DS:H00630]
Giant Cell Arteritis [DS:H01698]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Systemic juvenile idiopathic arthritis [DS:H01672]
Comment
Monoclonal antibody
Target
IL6R (CD126) [HSA:3570] [KO:K05055]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Interaction
Drug interaction
Structure map
map07050  Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC07 Tocilizumab
      D02596  Tocilizumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Tocilizumab
    D02596  Tocilizumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02596  Tocilizumab (USAN/INN); Tocilizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL6R (CD126)
     D02596  Tocilizumab (USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D02596
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02596
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02596
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02596
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02596
BRITE hierarchy
Other DBs
CAS: 375823-41-9
PubChem: 17396767
NIKKAJI: J2.104.935B
LinkDB All DBs

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