KEGG   DRUG: AzacitidineHelp
Entry
D03021                      Drug                                   

Name
Azacitidine (JAN/USAN/INN);
Vidaza (TN)
Product
  Generic
Formula
C8H12N4O5
Exact mass
244.0808
Mol weight
244.2047
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Same as: C11262
Therapeutic category: 4291
ATC code: L01BC07
Product: D03021<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Myelodysplastic syndrome [DS:H01481]
Comment
Cytidine [CPD:C00475] analog
Target
DNMT [HSA:1786 1788 1789] [KO:K00558 K17398 K17399]
  Pathway
hsa00270  Cysteine and methionine metabolism
hsa05206  MicroRNAs in cancer
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC07 Azacitidine
      D03021  Azacitidine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Azacitidine
    D03021  Azacitidine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03021  Azacitidine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    DNMT
     D03021  Azacitidine (JAN/USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D03021
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03021
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03021
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03021
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03021
BRITE hierarchy
Other DBs
CAS: 320-67-2
PubChem: 17397176
ChEBI: 2038
ChEMBL: CHEMBL1489
DrugBank: DB00928
PDB-CCD: 5AE[PDBj]
LigandBox: D03021
NIKKAJI: J1.523G
LinkDB All DBs
KCF data Show

ATOM        17
            1   C1y C    18.3340  -16.0895
            2   N4y N    19.6665  -15.6575
            3   C1y C    17.9014  -17.4167
            4   O2x O    17.1998  -15.2653
            5   C1y C    16.4982  -17.4167
            6   C1y C    16.0656  -16.0895
            7   O1a O    15.6799  -18.5506
            8   C1b C    14.7328  -15.6569
            9   O1a O    13.6982  -16.5982
            10  O1a O    18.7229  -18.5485
            11  C8x C    19.6636  -14.2586
            12  C8y C    20.8795  -16.3543
            13  N5x N    22.0894  -15.6524
            14  C8y C    22.0865  -14.2536
            15  N5x N    20.8736  -13.5567
            16  O5x O    20.8822  -17.7618
            17  N1a N    23.2968  -13.5514
BOND        18
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     3   5 1
            5     4   6 1
            6     5   7 1 #Down
            7     6   8 1 #Up
            8     8   9 1
            9     5   6 1
            10    3  10 1 #Down
            11    2  11 1
            12    2  12 1
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   11  15 2
            17   12  16 2
            18   14  17 1

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