KEGG   DRUG: Bleomycin hydrochlorideHelp
Entry
D03229                      Drug                                   

Name
Bleomycin hydrochloride (JP17);
BLM;
Bleo (TN)
Formula
C50H71N16O21S2R. xHCl
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 4234
ATC code: L01DC01
Chemical structure group: DG00705
Product (DG00705): D02177<JP/US> D03229<JP>
Efficacy
Antibiotic, Antineoplastic
Comment
DNA synthesis inhibitor
Target
DNA
Interaction
Drug interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DC Other cytotoxic antibiotics
     L01DC01 Bleomycin
      D03229  Bleomycin hydrochloride (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4234  Bleomycins
     D03229  Bleomycin hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D03229  Bleomycin hydrochloride
Antineoplastics [br08340.html]
 D03229
BRITE hierarchy
Other DBs
CAS: 67763-87-5
PubChem: 17397382
DrugBank: DB00290
LinkDB All DBs
KCF data Show

ATOM        91
            1   C1c C    32.2983  -16.7720
            2   C5a C    33.4869  -16.0728
            3   N1b N    34.6754  -16.7720
            4   C1c C    32.2983  -18.1703
            5   O1a O    31.1097  -18.8694
            6   C1a C    33.4869  -18.8694
            7   O5a O    33.4869  -14.6745
            8   C1b C    35.8640  -16.0728
            9   C1c C    24.0483  -19.4288
            10  C5a C    25.2368  -18.7296
            11  N1b N    26.3554  -19.4288
            12  O5a O    25.2368  -17.3313
            13  C1c C    27.5440  -18.7296
            14  C1c C    27.5440  -16.7720
            15  C1c C    28.7327  -16.0728
            16  O1a O    26.3554  -16.0728
            17  C5a C    29.9212  -16.7720
            18  N1b N    31.1097  -16.0728
            19  O5a O    29.9212  -18.1703
            20  C1a C    28.7327  -14.6745
            21  C1a C    28.7327  -19.4288
            22  N5x N    19.2240  -15.2339
            23  C8y C    19.2240  -16.6322
            24  C8y C    20.4126  -17.3313
            25  C8y C    21.6711  -16.6322
            26  N5x N    21.6711  -15.2339
            27  C8y C    20.4126  -14.5347
            28  C1c C    20.4126  -13.1364
            29  N1a N    18.0355  -17.3313
            30  C5a C    22.8596  -17.3313
            31  N1b N    21.6012  -12.4371
            32  C1b C    22.7897  -13.1364
            33  C1c C    23.9783  -12.4371
            34  C5a C    25.1669  -13.1364
            35  N1a N    23.9783  -11.0388
            36  N1a N    26.3554  -12.4371
            37  O5a O    25.1669  -14.5347
            38  O5a O    24.0483  -16.6322
            39  N1b N    22.8596  -18.7296
            40  C1a C    20.4126  -18.7296
            41  C1b C    19.2240  -12.4371
            42  C5a C    18.0355  -13.1364
            43  N1a N    16.8469  -12.4371
            44  O5a O    18.0355  -14.5347
            45  C1b C    37.0525  -16.7720
            46  C8y C    37.0525  -18.1703
            47  S2x S    35.9339  -19.0093
            48  C8x C    36.3534  -20.3376
            49  C8y C    37.8216  -20.3376
            50  N5x N    38.2412  -19.0093
            51  C1c C    24.0483  -20.8271
            52  O2a O    22.8596  -21.5263
            53  C1y C    21.6012  -20.8970
            54  O2x O    20.4126  -20.1978
            55  C1y C    19.1542  -20.8970
            56  C1y C    19.1542  -22.2954
            57  C1y C    20.4126  -22.9945
            58  C1y C    21.6012  -22.2954
            59  C1b C    17.9655  -20.1978
            60  O1a O    16.7770  -20.8970
            61  O1a O    17.9655  -22.9945
            62  O1a O    20.4126  -24.3229
            63  O2a O    22.7897  -22.9945
            64  C1y C    22.7897  -24.3229
            65  O2x O    21.6012  -25.0221
            66  C1y C    21.6012  -26.4205
            67  C1y C    22.7897  -27.1195
            68  C1y C    24.0483  -26.4205
            69  C1y C    24.0483  -25.0221
            70  C1b C    20.4126  -27.1195
            71  O1a O    22.7897  -28.5178
            72  O7a O    25.4465  -27.1195
            73  O1a O    25.2368  -24.3229
            74  C8y C    25.2368  -21.5263
            75  N5x N    25.2368  -22.9246
            76  C8x C    26.4953  -23.3441
            77  N4x N    27.3343  -22.2254
            78  C8x C    26.4953  -21.1068
            79  S2x S    37.6963  -22.6797
            80  C8y C    38.5208  -21.5486
            81  C8x C    38.5180  -23.8111
            82  C8y C    39.8481  -23.3792
            83  N5x N    39.8483  -21.9809
            84  C5a C    41.0588  -24.0787
            85  R   R    42.2700  -23.3797
            86  O5a O    41.0590  -25.5113
            87  C7a C    26.8729  -26.4303
            88  N1a N    28.0530  -27.1245
            89  O6a O    26.8847  -25.0227
            90  O1a O    19.1960  -26.4303
            91  X   Cl   35.9102  -12.5301
BOND        95
            1     1   2 1
            2     2   3 1
            3     1   4 1
            4     4   5 1 #Up
            5     4   6 1
            6     2   7 2
            7     3   8 1
            8     9  10 1
            9    10  11 1
            10   10  12 2
            11   11  13 1
            12   13  14 1
            13   14  15 1
            14   14  16 1 #Up
            15   15  17 1
            16   17  18 1
            17   17  19 2
            18   15  20 1 #Down
            19   13  21 1 #Up
            20   22  23 2
            21   23  24 1
            22   24  25 2
            23   25  26 1
            24   26  27 2
            25   22  27 1
            26   27  28 1
            27   23  29 1
            28   25  30 1
            29   28  31 1
            30   31  32 1
            31   32  33 1
            32   33  34 1
            33   33  35 1 #Down
            34   34  36 1
            35   34  37 2
            36   30  38 2
            37   30  39 1
            38   24  40 1
            39   41  42 1
            40   28  41 1 #Down
            41   42  43 1
            42   42  44 2
            43    9  39 1 #Down
            44    1  18 1 #Down
            45    8  45 1
            46   45  46 1
            47   46  47 1
            48   47  48 1
            49   48  49 2
            50   49  50 1
            51   46  50 2
            52    9  51 1
            53   53  52 1 #Up
            54   53  54 1
            55   54  55 1
            56   55  56 1
            57   56  57 1
            58   57  58 1
            59   53  58 1
            60   55  59 1 #Down
            61   59  60 1
            62   56  61 1 #Down
            63   57  62 1 #Up
            64   58  63 1 #Up
            65   64  63 1 #Down
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   64  69 1
            72   66  70 1 #Up
            73   67  71 1 #Down
            74   68  72 1 #Up
            75   69  73 1 #Up
            76   51  74 1
            77   74  75 1
            78   75  76 2
            79   76  77 1
            80   77  78 1
            81   74  78 2
            82   51  52 1 #Down
            83   79  80 1
            84   49  80 1
            85   79  81 1
            86   81  82 2
            87   82  83 1
            88   80  83 2
            89   82  84 1
            90   84  85 1
            91   84  86 2
            92   72  87 1
            93   87  88 1
            94   87  89 2
            95   70  90 1
BRACKET     1    34.4400  -13.3000   34.4400  -11.6200
            1    36.8200  -11.6200   36.8200  -13.3000
            1  x
 ORIGINAL  1   91
 REPEAT    1

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