KEGG   DRUG: Bleomycin sulfateHelp
Entry
D02177                      Drug                                   

Name
Bleomycin sulfate (JP17/USP);
Blenoxane (TN)
Product
  Generic
Formula
C50H71N16O21S2R. xH2SO4
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 4234
ATC code: L01DC01
Chemical structure group: DG00705
Product (DG00705): D02177<JP/US> D03229<JP>
Efficacy
Antibiotic, Antineoplastic
  Disease
Squamous cell carcinoma [DS:H00040]
Hodgkin's disease [DS:H00007]
Testicular carcinoma [DS:H00023]
Choriocarcinoma [DS:H00028]
Comment
Mixture of basic cytotoxic glycopeptide, sulfate salt of Bleomycin [CPD:C15773]
DNA synthesis inhibitor
Target
DNA
Interaction
Drug interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DC Other cytotoxic antibiotics
     L01DC01 Bleomycin
      D02177  Bleomycin sulfate (JP17/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4234  Bleomycins
     D02177  Bleomycin sulfate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02177  Bleomycin sulfate
Antineoplastics [br08340.html]
 D02177
BRITE hierarchy
Other DBs
CAS: 9041-93-4
PubChem: 7849238
ChEBI: 34582
DrugBank: DB00290
NIKKAJI: J2.200.722J
LinkDB All DBs
KCF data Show

ATOM        95
            1   S4a S    38.3283  -13.3487
            2   O1d O    38.3920  -11.9443
            3   O1d O    38.3920  -14.7528
            4   O1d O    39.7327  -13.3487
            5   O1d O    36.9242  -13.3487
            6   C1c C    32.2940  -16.7678
            7   C5a C    33.4825  -16.0687
            8   N1b N    34.6708  -16.7678
            9   C1c C    32.2940  -18.1658
            10  O1a O    31.1056  -18.8648
            11  C1a C    33.4825  -18.8648
            12  O5a O    33.4825  -14.6705
            13  C1b C    35.8593  -16.0687
            14  C1c C    24.0452  -19.4241
            15  C5a C    25.2335  -18.7250
            16  N1b N    26.3520  -19.4241
            17  O5a O    25.2335  -17.3269
            18  C1c C    27.5404  -18.7250
            19  C1c C    27.5404  -16.7678
            20  C1c C    28.7290  -16.0687
            21  O1a O    26.3520  -16.0687
            22  C5a C    29.9173  -16.7678
            23  N1b N    31.1056  -16.0687
            24  O5a O    29.9173  -18.1658
            25  C1a C    28.7290  -14.6705
            26  C1a C    28.7290  -19.4241
            27  N5x N    19.2216  -15.2299
            28  C8y C    19.2216  -16.6280
            29  C8y C    20.4101  -17.3269
            30  C8y C    21.6684  -16.6280
            31  N5x N    21.6684  -15.2299
            32  C8y C    20.4101  -14.5308
            33  C1c C    20.4101  -13.1326
            34  N1a N    18.0334  -17.3269
            35  C5a C    22.8568  -17.3269
            36  N1b N    21.5986  -12.4334
            37  C1b C    22.7869  -13.1326
            38  C1c C    23.9753  -12.4334
            39  C5a C    25.1636  -13.1326
            40  N1a N    23.9753  -11.0353
            41  N1a N    26.3520  -12.4334
            42  O5a O    25.1636  -14.5308
            43  O5a O    24.0452  -16.6280
            44  N1b N    22.8568  -18.7250
            45  C1a C    20.4101  -18.7250
            46  C1b C    19.2216  -12.4334
            47  C5a C    18.0334  -13.1326
            48  N1a N    16.8449  -12.4334
            49  O5a O    18.0334  -14.5308
            50  C1b C    37.0476  -16.7678
            51  C8y C    37.0476  -18.1658
            52  S2x S    35.9292  -19.0047
            53  C8x C    36.3486  -20.3328
            54  C8y C    37.8165  -20.3328
            55  N5x N    38.2361  -19.0047
            56  C1c C    24.0452  -20.8223
            57  O2a O    22.8568  -21.5214
            58  C1y C    21.5986  -20.8922
            59  O2x O    20.4101  -20.1931
            60  C1y C    19.1519  -20.8922
            61  C1y C    19.1519  -22.2903
            62  C1y C    20.4101  -22.9893
            63  C1y C    21.5986  -22.2903
            64  C1b C    17.9634  -20.1931
            65  O1a O    16.7751  -20.8922
            66  O1a O    17.9634  -22.9893
            67  O1a O    20.4101  -24.3174
            68  O2a O    22.7869  -22.9893
            69  C1y C    22.7869  -24.3174
            70  O2x O    21.5986  -25.0166
            71  C1y C    21.5986  -26.4148
            72  C1y C    22.7869  -27.1137
            73  C1y C    24.0452  -26.4148
            74  C1y C    24.0452  -25.0166
            75  C1b C    20.4101  -27.1137
            76  O1a O    22.7869  -28.5118
            77  O7a O    25.4432  -27.1137
            78  O1a O    25.2335  -24.3174
            79  C8y C    25.2335  -21.5214
            80  N5x N    25.2335  -22.9194
            81  C8x C    26.4918  -23.3388
            82  N4x N    27.3307  -22.2204
            83  C8x C    26.4918  -21.1019
            84  S2x S    37.6913  -22.6745
            85  C8y C    38.5157  -21.5437
            86  C8x C    38.5129  -23.8057
            87  C8y C    39.8428  -23.3739
            88  N5x N    39.8430  -21.9759
            89  C5a C    41.0533  -24.0733
            90  R   R    42.2643  -23.3744
            91  O5a O    41.0535  -25.5057
            92  C7a C    26.8694  -26.4246
            93  N1a N    28.0494  -27.1187
            94  O6a O    26.8812  -25.0172
            95  O1a O    19.1937  -26.4246
BOND        99
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     6   7 1
            6     7   8 1
            7     6   9 1
            8     9  10 1 #Up
            9     9  11 1
            10    7  12 2
            11    8  13 1
            12   14  15 1
            13   15  16 1
            14   15  17 2
            15   16  18 1
            16   18  19 1
            17   19  20 1
            18   19  21 1 #Up
            19   20  22 1
            20   22  23 1
            21   22  24 2
            22   20  25 1 #Down
            23   18  26 1 #Up
            24   27  28 2
            25   28  29 1
            26   29  30 2
            27   30  31 1
            28   31  32 2
            29   27  32 1
            30   32  33 1
            31   28  34 1
            32   30  35 1
            33   33  36 1
            34   36  37 1
            35   37  38 1
            36   38  39 1
            37   38  40 1 #Down
            38   39  41 1
            39   39  42 2
            40   35  43 2
            41   35  44 1
            42   29  45 1
            43   46  47 1
            44   33  46 1 #Down
            45   47  48 1
            46   47  49 2
            47   14  44 1 #Down
            48    6  23 1 #Down
            49   13  50 1
            50   50  51 1
            51   51  52 1
            52   52  53 1
            53   53  54 2
            54   54  55 1
            55   51  55 2
            56   14  56 1
            57   58  57 1 #Up
            58   58  59 1
            59   59  60 1
            60   60  61 1
            61   61  62 1
            62   62  63 1
            63   58  63 1
            64   60  64 1 #Down
            65   64  65 1
            66   61  66 1 #Down
            67   62  67 1 #Up
            68   63  68 1 #Up
            69   69  68 1 #Down
            70   69  70 1
            71   70  71 1
            72   71  72 1
            73   72  73 1
            74   73  74 1
            75   69  74 1
            76   71  75 1 #Up
            77   72  76 1 #Down
            78   73  77 1 #Up
            79   74  78 1 #Up
            80   56  79 1
            81   79  80 1
            82   80  81 2
            83   81  82 1
            84   82  83 1
            85   79  83 2
            86   56  57 1 #Down
            87   84  85 1
            88   54  85 1
            89   84  86 1
            90   86  87 2
            91   87  88 1
            92   85  88 2
            93   87  89 1
            94   89  90 1
            95   89  91 2
            96   77  92 1
            97   92  93 1
            98   92  94 2
            99   75  95 1
BRACKET     1    35.4900  -15.1200   35.4900  -11.2000
            1    40.8100  -11.2000   40.8100  -15.1200
            1  x
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1

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