KEGG   DRUG: Bleomycin sulfate
Entry
D02177                      Drug                                   
Name
Bleomycin sulfate (JP18/USP);
Blenoxane (TN)
Product
  Generic
BLEOMYCIN (Cipla USA), BLEOMYCIN (Fresenius Kabi USA), BLEOMYCIN (Hikma Pharmaceuticals USA), BLEOMYCIN (Hospira), BLEOMYCIN (Hospira), BLEOMYCIN (Meitheal Pharmaceuticals), BLEOMYCIN (NorthStar Rx LLC)
Formula
C50H71N16O21S2R. xH2SO4
Structure
Simcomp
Remark
Therapeutic category: 4234
ATC code: L01DC01
Chemical structure group: DG00705
Product (DG00705): D02177<JP/US> D03229<JP>
Efficacy
Antibiotic, Antineoplastic
  Disease
Squamous cell carcinoma [DS:H00040]
Hodgkin's disease [DS:H00007]
Non-Hodgkin's lymphoma [DS:H02418]
Testicular carcinoma [DS:H00023]
Choriocarcinoma [DS:H00028]
Comment
Mixture of basic cytotoxic glycopeptide, sulfate salt of Bleomycin [CPD:C15773]
DNA synthesis inhibitor
Target
DNA
Interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DC Other cytotoxic antibiotics
     L01DC01 Bleomycin
      D02177  Bleomycin sulfate (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4234  Bleomycins
     D02177  Bleomycin sulfate (JP18/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02177  Bleomycin sulfate
Other DBs
CAS: 9041-93-4
PubChem: 7849238
ChEBI: 34582
NIKKAJI: J2.200.722J
LinkDB
KCF data

ATOM        95
            1   S4a S    38.3283  -13.3487
            2   O1d O    38.3920  -11.9443
            3   O1d O    38.3920  -14.7528
            4   O1d O    39.7327  -13.3487
            5   O1d O    36.9242  -13.3487
            6   C1c C    32.2940  -16.7678
            7   C5a C    33.4825  -16.0687
            8   N1b N    34.6708  -16.7678
            9   C1c C    32.2940  -18.1658
            10  O1a O    31.1056  -18.8648
            11  C1a C    33.4825  -18.8648
            12  O5a O    33.4825  -14.6705
            13  C1b C    35.8593  -16.0687
            14  C1c C    24.0452  -19.4241
            15  C5a C    25.2335  -18.7250
            16  N1b N    26.3520  -19.4241
            17  O5a O    25.2335  -17.3269
            18  C1c C    27.5404  -18.7250
            19  C1c C    27.5404  -16.7678
            20  C1c C    28.7290  -16.0687
            21  O1a O    26.3520  -16.0687
            22  C5a C    29.9173  -16.7678
            23  N1b N    31.1056  -16.0687
            24  O5a O    29.9173  -18.1658
            25  C1a C    28.7290  -14.6705
            26  C1a C    28.7290  -19.4241
            27  N5x N    19.2216  -15.2299
            28  C8y C    19.2216  -16.6280
            29  C8y C    20.4101  -17.3269
            30  C8y C    21.6684  -16.6280
            31  N5x N    21.6684  -15.2299
            32  C8y C    20.4101  -14.5308
            33  C1c C    20.4101  -13.1326
            34  N1a N    18.0334  -17.3269
            35  C5a C    22.8568  -17.3269
            36  N1b N    21.5986  -12.4334
            37  C1b C    22.7869  -13.1326
            38  C1c C    23.9753  -12.4334
            39  C5a C    25.1636  -13.1326
            40  N1a N    23.9753  -11.0353
            41  N1a N    26.3520  -12.4334
            42  O5a O    25.1636  -14.5308
            43  O5a O    24.0452  -16.6280
            44  N1b N    22.8568  -18.7250
            45  C1a C    20.4101  -18.7250
            46  C1b C    19.2216  -12.4334
            47  C5a C    18.0334  -13.1326
            48  N1a N    16.8449  -12.4334
            49  O5a O    18.0334  -14.5308
            50  C1b C    37.0476  -16.7678
            51  C8y C    37.0476  -18.1658
            52  S2x S    35.9292  -19.0047
            53  C8x C    36.3486  -20.3328
            54  C8y C    37.8165  -20.3328
            55  N5x N    38.2361  -19.0047
            56  C1c C    24.0452  -20.8223
            57  O2a O    22.8568  -21.5214
            58  C1y C    21.5986  -20.8922
            59  O2x O    20.4101  -20.1931
            60  C1y C    19.1519  -20.8922
            61  C1y C    19.1519  -22.2903
            62  C1y C    20.4101  -22.9893
            63  C1y C    21.5986  -22.2903
            64  C1b C    17.9634  -20.1931
            65  O1a O    16.7751  -20.8922
            66  O1a O    17.9634  -22.9893
            67  O1a O    20.4101  -24.3174
            68  O2a O    22.7869  -22.9893
            69  C1y C    22.7869  -24.3174
            70  O2x O    21.5986  -25.0166
            71  C1y C    21.5986  -26.4148
            72  C1y C    22.7869  -27.1137
            73  C1y C    24.0452  -26.4148
            74  C1y C    24.0452  -25.0166
            75  C1b C    20.4101  -27.1137
            76  O1a O    22.7869  -28.5118
            77  O7a O    25.4432  -27.1137
            78  O1a O    25.2335  -24.3174
            79  C8y C    25.2335  -21.5214
            80  N5x N    25.2335  -22.9194
            81  C8x C    26.4918  -23.3388
            82  N4x N    27.3307  -22.2204
            83  C8x C    26.4918  -21.1019
            84  S2x S    37.6913  -22.6745
            85  C8y C    38.5157  -21.5437
            86  C8x C    38.5129  -23.8057
            87  C8y C    39.8428  -23.3739
            88  N5x N    39.8430  -21.9759
            89  C5a C    41.0533  -24.0733
            90  R   R    42.2643  -23.3744
            91  O5a O    41.0535  -25.5057
            92  C7a C    26.8694  -26.4246
            93  N1a N    28.0494  -27.1187
            94  O6a O    26.8812  -25.0172
            95  O1a O    19.1937  -26.4246
BOND        99
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     6   7 1
            6     7   8 1
            7     6   9 1
            8     9  10 1 #Up
            9     9  11 1
            10    7  12 2
            11    8  13 1
            12   14  15 1
            13   15  16 1
            14   15  17 2
            15   16  18 1
            16   18  19 1
            17   19  20 1
            18   19  21 1 #Up
            19   20  22 1
            20   22  23 1
            21   22  24 2
            22   20  25 1 #Down
            23   18  26 1 #Up
            24   27  28 2
            25   28  29 1
            26   29  30 2
            27   30  31 1
            28   31  32 2
            29   27  32 1
            30   32  33 1
            31   28  34 1
            32   30  35 1
            33   33  36 1
            34   36  37 1
            35   37  38 1
            36   38  39 1
            37   38  40 1 #Down
            38   39  41 1
            39   39  42 2
            40   35  43 2
            41   35  44 1
            42   29  45 1
            43   46  47 1
            44   33  46 1 #Down
            45   47  48 1
            46   47  49 2
            47   14  44 1 #Down
            48    6  23 1 #Down
            49   13  50 1
            50   50  51 1
            51   51  52 1
            52   52  53 1
            53   53  54 2
            54   54  55 1
            55   51  55 2
            56   14  56 1
            57   58  57 1 #Up
            58   58  59 1
            59   59  60 1
            60   60  61 1
            61   61  62 1
            62   62  63 1
            63   58  63 1
            64   60  64 1 #Down
            65   64  65 1
            66   61  66 1 #Down
            67   62  67 1 #Up
            68   63  68 1 #Up
            69   69  68 1 #Down
            70   69  70 1
            71   70  71 1
            72   71  72 1
            73   72  73 1
            74   73  74 1
            75   69  74 1
            76   71  75 1 #Up
            77   72  76 1 #Down
            78   73  77 1 #Up
            79   74  78 1 #Up
            80   56  79 1
            81   79  80 1
            82   80  81 2
            83   81  82 1
            84   82  83 1
            85   79  83 2
            86   56  57 1 #Down
            87   84  85 1
            88   54  85 1
            89   84  86 1
            90   86  87 2
            91   87  88 1
            92   85  88 2
            93   87  89 1
            94   89  90 1
            95   89  91 2
            96   77  92 1
            97   92  93 1
            98   92  94 2
            99   75  95 1
BRACKET     1    35.4900  -15.1200   35.4900  -11.2000
            1    40.8100  -11.2000   40.8100  -15.1200
            1  x
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1

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