| Entry |
|
|---|
| Name |
Zuclopenthixol (INN);
Clopixol (TN) |
|---|
| Formula |
C22H25ClN2OS
|
|---|
| Exact mass |
400.1376
|
|---|
| Mol weight |
400.96
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antipsychotic, Dopamine receptor antagonist |
|---|
| Comment |
Thioxanthene derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AF Thioxanthene derivatives
N05AF05 Zuclopenthixol
D03556 Zuclopenthixol (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG00896 Zuclopenthixol
D03556 Zuclopenthixol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00896 Zuclopenthixol
D03556 Zuclopenthixol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD1
D03556 Zuclopenthixol (INN)
DRD2
D03556 Zuclopenthixol (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03556
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG00896 Zuclopenthixol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00896 Zuclopenthixol
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C8x C 12.9655 -16.6834
2 C8x C 12.9655 -18.0852
3 C8x C 14.1794 -18.7860
4 C8y C 15.3934 -18.0852
5 C8y C 15.3934 -16.6834
6 C8x C 14.1794 -15.9826
7 S2x S 16.6073 -18.7860
8 C8y C 17.8212 -18.0852
9 C8y C 17.8212 -16.6834
10 C8y C 16.6073 -15.9826
11 C8x C 19.0352 -18.7860
12 C8x C 20.2491 -18.0852
13 C8y C 20.2491 -16.6834
14 C8x C 19.0352 -15.9826
15 C2b C 16.6073 -14.5808
16 C1b C 17.8233 -13.8788
17 C1b C 17.8233 -12.4770
18 N1y N 19.0202 -11.7858
19 C1x C 20.2100 -12.4727
20 C1x C 21.4239 -11.7719
21 N1y N 21.4239 -10.3701
22 C1x C 20.2341 -9.6832
23 C1x C 19.0202 -10.3841
24 C1b C 22.6598 -9.6748
25 C1b C 23.8738 -10.3756
26 O1a O 25.0877 -9.6748
27 X Cl 21.4671 -15.9803
BOND 30
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 5 10 1
12 8 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 9 14 1
17 10 15 2
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 18 23 1
27 21 24 1
28 24 25 1
29 25 26 1
30 13 27 1
|
|---|
