KEGG T01001: 1812

Homo sapiens (human): 1812

Entry

1812              CDS       T01001

Symbol

DRD1, D1R, DADR, DRD1A

Name

(RefSeq) dopamine receptor D1

K04144

dopamine receptor D1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04082

Neuroactive ligand signaling

hsa04540

Gap junction

hsa04728

Dopaminergic synapse

hsa05012

Parkinson disease

hsa05030

Cocaine addiction

hsa05031

Amphetamine addiction

hsa05032

Morphine addiction

hsa05034

Alcoholism

Network

nt06167 Human cytomegalovirus (HCMV)
nt06544 Neuroactive ligand signaling

Element

N00410

DRD1-GNAS-AC-PKA signaling pathway

N01897

Dopamine-DRD-GNAQ/S signaling pathway

Drug target

Acepromazine (DG00870):

D02604 D07065

Acetophenazine (DG00878):

D00788

Adrogolide hydrochloride:

D02775

Apomorphine (DG00486):

D02004<JP/US> D07460

Butaclamol hydrochloride:

D02641

Carphenazine maleate:

D02644

Chlorprothixene (DG00894):

D00790 D02162 D07686 D07687

Ciladopa hydrochloride:

D03494

Clopenthixol:

D02613

Dexpramipexole (DG01331):

D09886 D09887

Docarpamine:

D01903<JP>

Dopamine (DG00213):

D00633<JP/US> D07870

Dopexamine (DG00222):

D03891 D03892

Ecopipam hydrochloride:

D03937

Etilevodopa:

D04097

Fenoldopam (DG00226):

D00613 D07946

Flupentixol (DG00893):

D01044 D02236 D07976

Foslevodopa:

D11839

Ibopamine (DG00223):

D04488 D08057

Levodopa:

D00059<JP/US>

Mevidalen (DG03111):

D11822 D11826

Oxiperomide:

D02676

Pergolide (DG00861):

D00502<JP> D08339

Pipotiazine (DG00884):

D02680 D08385

Razpipadon:

D12766

Tavapadon:

D11431

Zicronapine (DG01539):

D10329 D10495

Zuclopenthixol (DG00896):

D03556 D08691 D08692 D08693

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1812 (DRD1)
   04024 cAMP signaling pathway
    1812 (DRD1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1812 (DRD1)
   04082 Neuroactive ligand signaling
    1812 (DRD1)
   04081 Hormone signaling
    1812 (DRD1)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    1812 (DRD1)
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1812 (DRD1)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    1812 (DRD1)
  09165 Substance dependence
   05030 Cocaine addiction
    1812 (DRD1)
   05031 Amphetamine addiction
    1812 (DRD1)
   05032 Morphine addiction
    1812 (DRD1)
   05034 Alcoholism
    1812 (DRD1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1812 (DRD1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Dopamine
    1812 (DRD1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx DUF621

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

5:complement(175440036..175444182)

AA seq 446 aa
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT

NT seq 1341 nt +upstreamnt +downstreamnt
atgaggactctgaacacctctgccatggacgggactgggctggtggtggagagggacttc
tctgttcgtatcctcactgcctgtttcctgtcgctgctcatcctgtccacgctcctgggg
aacacgctggtctgtgctgccgttatcaggttccgacacctgcggtccaaggtgaccaac
ttctttgtcatctccttggctgtgtcagatctcttggtggccgtcctggtcatgccctgg
aaggcagtggctgagattgctggcttctggccctttgggtccttctgtaacatctgggtg
gcctttgacatcatgtgctccactgcatccatcctcaacctctgtgtgatcagcgtggac
aggtattgggctatctccagccctttccggtatgagagaaagatgacccccaaggcagcc
ttcatcctgatcagtgtggcatggaccttgtctgtactcatctccttcatcccagtgcag
ctcagctggcacaaggcaaaacccacaagcccctctgatggaaatgccacttccctggct
gagaccatagacaactgtgactccagcctcagcaggacatatgccatctcatcctctgta
ataagcttttacatccctgtggccatcatgattgtcacctacaccaggatctacaggatt
gctcagaaacaaatacggcgcattgcggccttggagagggcagcagtccacgccaagaat
tgccagaccaccacaggtaatggaaagcctgtcgaatgttctcaaccggaaagttctttt
aagatgtccttcaaaagagaaactaaagtcctgaagactctgtcggtgatcatgggtgtg
tttgtgtgctgttggctacctttcttcatcttgaactgcattttgcccttctgtgggtct
ggggagacgcagcccttctgcattgattccaacacctttgacgtgtttgtgtggtttggg
tgggctaattcatccttgaaccccatcatttatgcctttaatgctgattttcggaaggca
ttttcaaccctcttaggatgctacagactttgccctgcgacgaataatgccatagagacg
gtgagtatcaataacaatggggccgcgatgttttccagccatcatgagccacgaggctcc
atctccaaggagtgcaatctggtttacctgatcccacatgctgtgggctcctctgaggac
ctgaaaaaggaggaggcagctggcatcgccagacccttggagaagctgtccccagcccta
tcagtcatattggactatgacactgacgtctctctggagaagatccaacccatcacacaa
aacggtcagcacccaacctga

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