KEGG   DRUG: DaclizumabHelp
Entry
D03639                      Drug                                   

Name
Daclizumab (USAN/INN);
Zenapax (TN);
Zinbryta (TN)
Product
Formula
C6394H9888N1696O2012S44
Exact mass
144031.1268
Mol weight
144119.9425
Sequence
(Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGYTFT SYRMHWVRQA
PGQGLEWIGY INPSTGYTEY NQKFKDKATI TADESTNTAY MELSSLRSED TAVYYCARGG
GVFDYWGQGT LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG
ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD
KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG
VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96; 143-199; 260-320; 366-424, Dimer: 225; 228)
(Light chain) DIQMTQSPST LSASVGDRVT ITCSASSSIS YMHWYQQKPG
KAPKLLIYTT SNLASGVPAR FSGSGSGTEF TLTISSLQPD DFATYYCHQR STYPLTFGQG
TKVEVKRTVA APSVFIFPPS DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE
SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: 23-87; 133-193; H219-L213, Dimer)
  Type
Peptide
Class
Other
 DG02019  Interleukin inhibitor
Remark
ATC code: L04AC01
Product: D03639<US>
Efficacy
Immunosuppressant, Anti-CD25 antibody
  Disease
Multiple sclerosis [DS:H01490]
Comment
Monoclonal antibody
Target
IL2RA (CD25) [HSA:3559] [KO:K05068]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04144  Endocytosis
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC01 Daclizumab
      D03639  Daclizumab (USAN/INN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Daclizumab
    D03639  Daclizumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL2RA (CD25)
     D03639  Daclizumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03639
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03639
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03639
BRITE hierarchy
Other DBs
CAS: 152923-56-3
PubChem: 17397742
DrugBank: DB00111
LinkDB All DBs

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