KEGG   DRUG: DecitabineHelp
Entry
D03665                      Drug                                   

Name
Decitabine (USAN/INN);
Dacogen (TN)
Product
  Generic
Formula
C8H12N4O4
Exact mass
228.0859
Mol weight
228.2053
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
ATC code: L01BC08
Product: D03665<US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Myelodysplastic syndromes [DS:H01481]
Comment
Cytidine [CPD:C00475] analog
Target
DNMT [HSA:1786 1788 1789] [KO:K00558 K17398 K17399]
  Pathway
hsa00270  Cysteine and methionine metabolism
hsa05206  MicroRNAs in cancer
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC08 Decitabine
      D03665  Decitabine (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    DNMT
     D03665  Decitabine (USAN/INN) <US>
Antineoplastics [br08340.html]
 D03665
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03665
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03665
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03665
BRITE hierarchy
Other DBs
CAS: 2353-33-5
PubChem: 17397761
ChEMBL: CHEMBL1201129 CHEMBL2001850
DrugBank: DB01262
LigandBox: D03665
NIKKAJI: J91.053H
LinkDB All DBs
KCF data Show

ATOM        16
            1   C1y C    27.5800  -21.1400
            2   C1x C    28.9800  -21.1400
            3   C1y C    29.4000  -19.8100
            4   O2x O    28.2800  -18.9700
            5   C1y C    27.1600  -19.8100
            6   C1b C    25.8300  -19.3900
            7   O1a O    26.7400  -22.2600
            8   O1a O    24.7800  -20.3000
            9   N4y N    30.7330  -19.3820
            10  C8y C    31.9454  -20.0820
            11  N5x N    33.1578  -19.3820
            12  C8y C    33.1578  -17.9820
            13  N5x N    31.9454  -17.2820
            14  C8x C    30.7330  -17.9820
            15  O5x O    31.9455  -21.4898
            16  N1a N    34.3832  -17.2743
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     5   6 1 #Up
            7     1   7 1 #Down
            8     6   8 1
            9     3   9 1 #Up
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   10  15 2
            17   12  16 1

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