KEGG   DRUG: Decitabine
Entry
D03665                      Drug                                   
Name
Decitabine (USAN/INN);
Dacogen (TN)
Product
  Generic
Formula
C8H12N4O4
Exact mass
228.0859
Mol weight
228.2053
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
ATC code: L01BC08
Product: D03665<US>
Product (mixture): D11848<US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Myelodysplastic syndromes [DS:H01481]
Comment
Cytidine [CPD:C00475] analog
Target
DNMT [HSA:1786 1788 1789] [KO:K00558 K17398 K17399]
  Pathway
hsa00270  Cysteine and methionine metabolism
hsa05206  MicroRNAs in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC08 Decitabine
      D03665  Decitabine (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antimetabolites
   Decitabine
    D03665  Decitabine (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     D03665  Decitabine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D03665  Decitabine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    DNMT
     D03665  Decitabine (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03665
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03665
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03665
Other DBs
CAS: 2353-33-5
PubChem: 17397761
LigandBox: D03665
NIKKAJI: J91.053H
LinkDB
KCF data

ATOM        16
            1   C1y C    27.5800  -21.1400
            2   C1x C    28.9800  -21.1400
            3   C1y C    29.4000  -19.8100
            4   O2x O    28.2800  -18.9700
            5   C1y C    27.1600  -19.8100
            6   C1b C    25.8300  -19.3900
            7   O1a O    26.7400  -22.2600
            8   O1a O    24.7800  -20.3000
            9   N4y N    30.7330  -19.3820
            10  C8y C    31.9454  -20.0820
            11  N5x N    33.1578  -19.3820
            12  C8y C    33.1578  -17.9820
            13  N5x N    31.9454  -17.2820
            14  C8x C    30.7330  -17.9820
            15  O5x O    31.9455  -21.4898
            16  N1a N    34.3832  -17.2743
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     5   6 1 #Up
            7     1   7 1 #Down
            8     6   8 1
            9     3   9 1 #Up
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   10  15 2
            17   12  16 1

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