KEGG   DRUG: DesoximetasoneHelp
Entry
D03697                      Drug                                   

Name
Desoximetasone (USP/INN);
Topicort (TN)
Product
  Generic
DESOXIMETASONE (A-S Medication Solutions), DESOXIMETASONE (Actavis Pharma), DESOXIMETASONE (Actavis Pharma), DESOXIMETASONE (Cadila Healthcare Limited), DESOXIMETASONE (E. FOUGERA &), DESOXIMETASONE (E. Fougera &), DESOXIMETASONE (G&W Laboratories), DESOXIMETASONE (GROUPE PARIMA), DESOXIMETASONE (GROUPE PARIMA), DESOXIMETASONE (Glenmark Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Novel Laboratories), DESOXIMETASONE (Perrigo New York), DESOXIMETASONE (Perrigo New York), DESOXIMETASONE (Proficient Rx LP), DESOXIMETASONE (RPK Pharmaceuticals), DESOXIMETASONE (Rebel Distributors Corp), DESOXIMETASONE (Rising Pharmaceuticals), DESOXIMETASONE (Rising Pharmaceuticals), TOPICORT (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), TOPICORT (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Teligent Pharma), DESOXIMETASONE (VersaPharm Inc. - an Akorn Company), DESOXIMETASONE (VersaPharm Inc. - an Akorn Company), DESOXIMETASONE (VersaPharm Incorporated), DESOXIMETASONE (VersaPharm Incorporated), DESOXIMETASONE (Zydus Pharmaceuticals (USA))
Formula
C22H29FO4
Exact mass
376.205
Mol weight
376.4617
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: D07AC03 D07XC02
Product: D03697<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Plaque psoriasis [DS:H01656]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC03 Desoximetasone
      D03697  Desoximetasone (USP/INN) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC02 Desoximetasone
      D03697  Desoximetasone (USP/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Desoximetasone
   D03697  Desoximetasone (USP/INN)
  Desoximetasone
   D03697  Desoximetasone (USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03697  Desoximetasone (USP/INN) <US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D03697
BRITE hierarchy
Other DBs
CAS: 382-67-2
PubChem: 17397790
ChEBI: 691037
ChEMBL: CHEMBL16829 CHEMBL1766
DrugBank: DB00547
LigandBox: D03697
NIKKAJI: J83.644C
LinkDB All DBs
KCF data Show

ATOM        27
            1   C2x C    24.2900  -24.2900
            2   C5x C    24.2900  -25.6900
            3   C2x C    25.5024  -26.3900
            4   C2y C    26.7149  -25.6900
            5   C1z C    26.7149  -24.2900
            6   C2x C    25.5024  -23.5900
            7   C1x C    27.9273  -26.3900
            8   C1x C    29.1397  -25.6900
            9   C1y C    29.1397  -24.2900
            10  C1z C    27.9273  -23.5900
            11  C1y C    30.3522  -23.5900
            12  C1z C    30.3522  -22.1900
            13  C1x C    29.1397  -21.4900
            14  C1y C    27.9273  -22.1900
            15  C1x C    32.7770  -23.5900
            16  C1y C    32.7770  -22.1900
            17  C1y C    31.5646  -21.4900
            18  C1a C    33.9766  -21.4973
            19  C5a C    31.5646  -19.8800
            20  C1a C    30.3522  -20.7900
            21  O1a O    26.7169  -21.4912
            22  C1a C    26.7149  -22.8900
            23  X   F    27.9273  -24.9900
            24  O5x O    23.0776  -26.3900
            25  O5a O    32.7811  -19.1777
            26  C1b C    30.3562  -19.1823
            27  O1a O    29.1627  -19.8716
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   16  18 1 #Down
            22   17  19 1 #Up
            23   12  20 1 #Up
            24   14  21 1 #Up
            25    5  22 1 #Up
            26   10  23 1 #Down
            27    2  24 2
            28   19  25 2
            29   19  26 1
            30   26  27 1

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