KEGG   DRUG: Dextrorphan hydrochloride
Entry
D03746                      Drug                                   
Name
Dextrorphan hydrochloride (USAN)
Formula
C17H23NO. HCl
Exact mass
293.1546
Mol weight
293.8316
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Efficacy
Antitussive, NMDA receptor antagonist
Comment
Opioid alkaloid derivative, morphinan
Vasospastic therapy adjunct
Target
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Interaction
Structure map
map07235  N-Methyl-D-aspartic acid (NMDA) receptor antagonists
Brite
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01498  NMDA receptor antagonist
   D03746  Dextrorphan hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D03746  Dextrorphan hydrochloride (USAN)
Narcotics and psychotropics in Japan [br08308.html]
 Narcotics by Control Act Article 2 Table 1 (74 substances)
  D03746
Other DBs
CAS: 69376-27-8
PubChem: 17397835
LigandBox: D03746
LinkDB
KCF data

ATOM        20
            1   C1z C    32.7439  -19.3484
            2   C8y C    32.7555  -18.0054
            3   C1y C    33.8882  -20.0375
            4   C1x C    34.0284  -18.4960
            5   C1x C    31.5642  -19.9967
            6   C8y C    33.9232  -17.3457
            7   C8x C    31.5876  -17.3223
            8   C1y C    35.0794  -19.3251
            9   C1x C    33.8767  -21.3805
            10  C1x C    36.2589  -18.5135
            11  C1x C    31.5409  -21.3455
            12  C1x C    35.0911  -18.0405
            13  C8x C    33.9408  -16.0027
            14  C8y C    31.5993  -15.9734
            15  N1y N    36.2474  -19.9908
            16  C1x C    32.6971  -22.0288
            17  C8x C    32.7905  -15.3137
            18  O1a O    30.4432  -15.2903
            19  C1a C    37.6253  -20.0024
            20  X   Cl   41.9300  -18.9000
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1 #Down
            15    9  16 1
            16   13  17 2
            17   14  18 1
            18   15  19 1
            19    8  12 1
            20   10  15 1
            21   11  16 1
            22   14  17 1

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