Homo sapiens (human): 2905
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Entry
2905 CDS
T01001
Symbol
GRIN2C, GluN2C, NMDAR2C, NR2C
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2C
KO
K05211
glutamate receptor ionotropic, NMDA 2C
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04082
Neuroactive ligand signaling
hsa04713
Circadian entrainment
hsa04720
Long-term potentiation
hsa04724
Glutamatergic synapse
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05031
Amphetamine addiction
hsa05033
Nicotine addiction
hsa05034
Alcoholism
Network
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06528
Calcium signaling
nt06544
Neuroactive ligand signaling
Element
N00970
Transport of calcium
N00971
Mutation-caused aberrant PDYN to transport of calcium
N00987
Mutation-caused aberrant Htt to transport of calcium
N01003
Mutation-caused aberrant Abeta to transport of calcium
N01200
Scrapie conformation PrPSc to transport of calcium
N01642
Ca2+ entry, Ligand-gated Ca2+ channel
N01880
GRM1/5-interacting scaffold proteins
Drug target
Acamprosate (
DG00996
):
D02780
<JP/US>
D07058
Amantadine (
DG00860
):
D00777
<JP/US>
D07441
Apimostinel:
D11299
Aptiganel hydrochloride:
D02973
Budipine (
DG00866
):
D07306
D07589
Dalzanemdor:
D12788
Delucemine hydrochloride:
D03679
Dextromethorphan (
DG01078
):
D00848
<JP>
D03742
D03744
Dextrorphan hydrochloride:
D03746
Dizocilpine maleate:
D03878
Esketamine (
DG01829
):
D07283
D10627
<US>
Esmethadone
Dextromethadone (
DG03176
):
D12214
D12215
Felbamate:
D00536
<US>
Gavestinel:
D04308
Ketamine (
DG00796
):
D00711
<JP/US>
D08098
Latrepirdine (
DG01379
):
D09917
D09918
Levomethadone (
DG01002
):
D08121
D08122
Licostinel:
D04728
Memantine (
DG00986
):
D04905
<JP/US>
D08174
Methadone (
DG00999
):
D02102
<JP/US>
D08195
Nevadistinel:
D12553
Orphenadrine (
DG01252
):
D08305
Orphenadrine (chloride):
D02599
Orphenadrine (citrate):
D00774
<US>
Perzinfotel:
D05447
Phencyclidine hydrochloride:
D05453
Remacemide hydrochloride:
D05714
Riluzole:
D00775
<JP/US>
Risevistinel:
D12554
Selfotel:
D02410
Tenocyclidine:
D12702
Tiletamine (
DG01380
):
D06146
D08596
Troriluzole (
DG03011
):
D11414
D11415
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
2905 (GRIN2C)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2905 (GRIN2C)
04082 Neuroactive ligand signaling
2905 (GRIN2C)
09150 Organismal Systems
09156 Nervous system
04724 Glutamatergic synapse
2905 (GRIN2C)
04720 Long-term potentiation
2905 (GRIN2C)
09159 Environmental adaptation
04713 Circadian entrainment
2905 (GRIN2C)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
2905 (GRIN2C)
05014 Amyotrophic lateral sclerosis
2905 (GRIN2C)
05017 Spinocerebellar ataxia
2905 (GRIN2C)
05020 Prion disease
2905 (GRIN2C)
05022 Pathways of neurodegeneration - multiple diseases
2905 (GRIN2C)
09165 Substance dependence
05030 Cocaine addiction
2905 (GRIN2C)
05031 Amphetamine addiction
2905 (GRIN2C)
05033 Nicotine addiction
2905 (GRIN2C)
05034 Alcoholism
2905 (GRIN2C)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
2905 (GRIN2C)
Ion channels [BR:
hsa04040
]
Ligand-gated channels
Glutamate (ionotropic)
2905 (GRIN2C)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Lig_chan
Lig_chan-Glu_bd
ANF_receptor
SBP_bac_3
NMDAR2_C
DUF63
Motif
Other DBs
NCBI-GeneID:
2905
NCBI-ProteinID:
NP_000826
OMIM:
138254
HGNC:
4587
Ensembl:
ENSG00000161509
UniProt:
Q14957
A0A8D9PH81
O15398
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(74842023..74861532)
Genome browser
AA seq
1233 aa
AA seq
DB search
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
NT seq
3702 nt
NT seq
+upstream
nt +downstream
nt
atgggtggggccctggggccggccctgttgctcacctcgctcttcggtgcctgggcaggg
ctgggtccggggcagggcgagcagggcatgacggtggccgtggtgtttagcagctcaggg
ccgccccaggcccagttccgtgcccgcctcaccccccagagcttcctggacctacccctg
gagatccagccgctcacagttggggtcaacaccaccaaccccagcagcctcctcacccag
atctgcggcctcctgggtgctgcccacgtccacggcattgtctttgaggacaacgtggac
accgaggcggtggcccagatccttgacttcatctcctcccagacccatgtgcccatcctc
agcatcagcggaggctctgctgtggtcctcacccccaaggagccgggctccgccttcctg
cagctgggcgtgtccctggagcagcagctgcaggtgctgttcaaggtgctggaagagtac
gactggagcgccttcgccgtcatcaccagcctgcacccgggccacgcgctcttcctggag
ggcgtgcgcgccgtcgccgacgccagccacgtgagttggcggctgctggacgtggtcacg
ctggagctgggcccgggagggccgcgcgcgcgcacgcagcgcctgctgcgccagctcgac
gcgcccgtgtttgtggcctactgctcgcgcgaggaggccgaggtgctcttcgccgaggcg
gcgcaggccggtctggtggggcccggccacgtgtggctggtgcccaacctggcgctgggc
agcaccgatgcgccccccgccaccttccccgtgggcctcatcagcgtcgtcaccgagagc
tggcgcctcagcctgcgccagaaggtgcgcgacggcgtggccattctggccctgggcgcc
cacagctactggcgccagcatggaaccctgccagccccggccggggactgccgtgttcac
cctgggcccgtcagccctgcccgggaggccttctacaggcacctactgaatgtcacctgg
gagggccgagacttctccttcagccctggtgggtacctggtccagcccaccatggtggtg
atcgccctcaaccggcaccgcctctgggagatggtggggcgctgggagcatggcgtccta
tacatgaagtaccccgtgtggcctcgctacagtgcctctctgcagcctgtggtggacagt
cggcacctgacggtggccacgctggaagagcggccctttgtcatcgtggagagccctgac
cctggcacaggaggctgtgtccccaacaccgtgccctgccgcaggcagagcaaccacacc
ttcagcagcggggacgtggccccctacaccaagctctgctgtaagggattctgcatcgac
atcctcaagaagctggccagagtggtcaaattctcctacgacctgtacctggtgaccaac
ggcaagcatggcaagcgggtgcgcggcgtatggaacggcatgattggggaggtgtactac
aagcgggcagacatggccatcggctccctcaccatcaatgaggaacgctccgagatcgta
gacttctctgtaccctttgtggagacgggcatcagtgtgatggtggctcgcagcaatggc
accgtctccccctcggccttcttggagccatatagccctgcagtgtgggtgatgatgttt
gtcatgtgcctcactgtggtggccatcaccgtcttcatgttcgagtacttcagccctgtc
agctacaaccagaacctcaccagaggcaagaagtccgggggcccagctttcactatcggc
aagtccgtgtggctgctgtgggcgctggtcttcaacaactcagtgcccatcgagaacccg
cggggcaccaccagcaagatcatggttctggtctgggccttctttgctgtcatcttcctc
gccagctacacggccaacctggccgccttcatgatccaagagcaatacatcgacactgtg
tcgggcctcagtgacaagaagtttcagcggcctcaagatcagtacccacctttccgcttc
ggcacggtgcccaacggcagcacggagcggaacatccgcagtaactaccgtgacatgcac
acccacatggtcaagttcaaccagcgctcggtggaggacgcgctcaccagcctcaagatg
gggaagctggatgccttcatctatgatgctgctgtcctcaactacatggcaggcaaggac
gagggctgcaagctggtcaccattgggtctggcaaggtctttgctaccactggctacggc
atcgccatgcagaaggactcccactggaagcgggccatagacctggcgctcttgcagttc
ctgggggacggagagacacagaaactggagacagtgtggctctcagggatctgccagaat
gagaagaacgaggtgatgagcagcaagctggacatcgacaacatggcaggcgtcttctac
atgctgctggtggccatggggctggccctgctggtcttcgcctgggagcacctggtctac
tggaagctgcgccactcggtgcccaactcatcccagctggacttcctgctggctttcagc
aggggcatctacagctgcttcagcggggtgcagagcctcgccagcccaccgcggcaggcc
agcccggacctcacggccagctcggcccaggccagcgtgctcaagatgctgcaggcagcc
cgcgacatggtgaccacggcgggcgtaagcagctccctggaccgcgccactcgcaccatc
gagaattggggtggcggccgccgtgcgcccccaccgtccccctgcccgaccccgcggtct
ggccccagcccatgcctgcccacccccgacccgcccccagagccgagccccacgggctgg
ggaccgccagacgggggtcgcgcggcgcttgtgcgcagggctccgcagcccccgggccgc
cccccgacgccggggccgcccctgtccgacgtctcccgagtgtcgcgccgcccagcctgg
gaggcgcggtggccggtgcggaccgggcactgcgggaggcacctctcggcctccgagcgg
cccctgtcgcccgcgcgctgtcactacagctcctttcctcgagccgaccgatccggccgc
cccttcctcccgctcttcccggagctggaggacctgccgctgctcggtccggagcagctg
gcccggcgggaggccctgctgcacgcggcctgggcccggggctcgcgcccgcgtcacgct
tccctgcccagctccgtggccgaggccttcgctcggcccagctcgctgcccgctgggtgc
accggccccgcctgcgcccgccccgacggccactcggcctgcaggcgcttggcgcaggcg
cagtcgatgtgcttgccgatctaccgggaggcctgccaggagggcgagcaggcaggggcc
cccgcctggcagcacagacagcacgtctgcctgcacgcccacgcccacctgccattttgc
tggggggctgtctgtcctcaccttccaccctgtgccagccacggctcctggctctccggg
gcctgggggcctctggggcacaggggcaggactctggggctgggcacaggctacagagac
agtgggggactggacgagatcagcagggtagcccgtgggacgcaaggcttcccgggaccc
tgcacctggagacggatctccagtctggagtcagaagtgtga
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integrated database retrieval system
