KEGG   DRUG: DirlotapideHelp
Entry
D03867                      Drug                                   

Name
Dirlotapide (USAN/INN);
Slentrol [veterinary] (TN)
Formula
C40H33F3N4O3
Exact mass
674.2505
Mol weight
674.7102
Structure
Mol fileKCF fileDB search
Efficacy
Antiobesity (veterinary), Gut microsomal triglyceride transport protein (gMTP) inhibitor
Comment
Not for use in humans.
veterinary medicine - Treatment of obesity in companion animals (dogs)
Target
MTTP [KO:K14463]
  Pathway
ko04975  Fat digestion and absorption
Brite
Animal drugs in Japan [BR:br08331]
 96  Agents affecting metabolism
  969  Other agents affecting metabolism
   9699  Agents affecting metabolism, n.e.c.
    D03867  Dirlotapide
BRITE hierarchy
Other DBs
CAS: 481658-94-0
PubChem: 17397951
ChEMBL: CHEMBL410414
LigandBox: D03867
LinkDB All DBs
KCF data Show

ATOM        50
            1   C8x C    23.1000  -16.1700
            2   C8y C    23.1000  -14.7700
            3   C8x C    21.8400  -14.0700
            4   C8y C    20.6500  -14.7700
            5   C8y C    20.6500  -16.1700
            6   C8x C    21.8400  -16.8700
            7   C8x C    19.3200  -14.2800
            8   C8y C    18.4800  -15.4700
            9   N4y N    19.3200  -16.5900
            10  C1a C    18.9000  -17.9200
            11  C5a C    17.0800  -15.4700
            12  N1b N    24.2900  -14.0700
            13  N1b N    16.3800  -14.2100
            14  O5a O    16.3800  -16.6600
            15  C1c C    14.9800  -14.2100
            16  C5a C    14.3500  -13.0200
            17  N1c N    12.8800  -13.0200
            18  C8y C    14.2800  -15.4700
            19  C8x C    12.8800  -15.4700
            20  C8x C    12.1800  -16.6600
            21  C8x C    12.8800  -17.9200
            22  C8x C    14.2800  -17.9200
            23  C8x C    14.9800  -16.6600
            24  O5a O    14.9800  -11.8300
            25  C1a C    12.1800  -14.2800
            26  C1b C    12.1800  -11.8300
            27  C8y C    10.7800  -11.8300
            28  C8x C    10.0800  -10.6400
            29  C8x C     8.6800  -10.6400
            30  C8x C     7.9800  -11.8300
            31  C8x C     8.6800  -13.0200
            32  C8x C    10.0800  -13.0200
            33  C5a C    25.4800  -14.7000
            34  C8y C    26.6700  -14.0700
            35  O5a O    25.4800  -16.1700
            36  C8y C    27.8600  -14.7000
            37  C8x C    29.1200  -14.0000
            38  C8x C    29.1200  -12.6000
            39  C8x C    27.8600  -11.9700
            40  C8x C    26.6700  -12.6700
            41  C8y C    27.8600  -16.1700
            42  C8x C    26.6700  -16.8700
            43  C8x C    26.6700  -18.2700
            44  C8y C    27.8600  -18.9700
            45  C8x C    29.1200  -18.2700
            46  C8x C    29.1200  -16.8700
            47  C1d C    27.8600  -20.3700
            48  X   F    27.8600  -21.7700
            49  X   F    29.2600  -20.3700
            50  X   F    26.4600  -20.3700
BOND        55
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    9  10 1
            12    8  11 1
            13    2  12 1
            14   11  13 1
            15   11  14 2
            16   13  15 1
            17   15  16 1
            18   16  17 1
            19   15  18 1 #Up
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   16  24 2
            27   17  25 1
            28   17  26 1
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   27  32 1
            36   12  33 1
            37   33  34 1
            38   33  35 2
            39   34  36 2
            40   36  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   34  40 1
            45   36  41 1
            46   41  42 2
            47   42  43 1
            48   43  44 2
            49   44  45 1
            50   45  46 2
            51   41  46 1
            52   44  47 1
            53   47  48 1
            54   47  49 1
            55   47  50 1

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