| Entry |
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| Name |
Eltrombopag olamine (JAN/USAN);
Promacta (TN) |
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| Product |
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| Formula |
C25H22N4O4. (C2H7NO)2
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| Exact mass |
564.2696
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| Mol weight |
564.6327
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| Structure |
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| Class |
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG02918 CYP2C8 substrate
DG02924 UGT substrate
Metabolizing enzyme inhibitor
DG02887 UGT inhibitor
Transporter substrate
DG01913 ABCG2 (BCRP) substrate
Transporter inhibitor
DG02862 ABCG2 (BCRP) inhibitor
DG02865 SLCO1B1 (OATP1B1) inhibitor
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| Remark |
| Therapeutic category: | 3999 |
|
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| Efficacy |
Antithrombocytopenia, Thrombopoietin receptor agonist |
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| Disease |
Chronic immune thrombocytopenia [DS: H01240] Aplastic anemia [DS: H01132] |
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| Comment |
Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura
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| Target |
|
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| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2C8 [HSA: 1558], UGT1A1 [HSA: 54658], UGT1A3 [HSA: 54659]
Transporter: ABCG2 [HSA: 9429]
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| Interaction |
Transporter inhibition: ABCG2 [HSA: 9429], SLCO1B1 [HSA: 10599]
Enzyme inhibition: UGT1A1 [HSA: 54658], UGT1A3 [HSA: 54659], UGT1A4 [HSA: 54657], UGT1A6 [HSA: 54578], UGT1A9 [HSA: 54600], UGT2B7 [HSA: 7364], UGT2B15 [HSA: 7366]
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B02 ANTIHEMORRHAGICS
B02B VITAMIN K AND OTHER HEMOSTATICS
B02BX Other systemic hemostatics
B02BX05 Eltrombopag
D03978 Eltrombopag olamine (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Blood Products and Modifiers
Blood Products and Modifiers, Other
Blood Products and Modifiers, Other
Eltrombopag Olamine
D03978 Eltrombopag olamine (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
399 Miscellaneous
3999 Others
D03978 Eltrombopag olamine (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
Cytokine receptors
CSF and other factor receptors
MPL (TPOR, CD110)
D03978 Eltrombopag olamine (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D03978
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D03978
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D03978
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D03978
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03978
Drug transporters
D03978
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D03978
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 N1a N 35.8702 -19.1003
2 C1b C 37.0869 -18.3978
3 C1b C 38.3036 -19.1003
4 O1a O 39.5203 -18.3978
5 N2x N 27.1600 -16.3800
6 C2y C 28.5600 -16.3800
7 C2y C 28.9926 -15.0485
8 C5x C 27.8600 -14.2256
9 N1y N 26.7274 -15.0485
10 O5x O 27.8600 -12.8100
11 C8y C 25.5149 -14.3485
12 C8x C 24.3025 -15.0485
13 N1b N 31.4175 -15.0485
14 N2b N 30.2051 -14.3485
15 C1a C 29.3829 -17.5126
16 C8x C 25.5149 -12.9485
17 C8x C 24.3025 -12.2485
18 C8y C 23.0901 -12.9485
19 C8y C 23.0901 -14.3485
20 C8y C 32.6299 -14.3485
21 C1a C 21.8845 -15.0446
22 C1a C 21.8857 -12.2532
23 C8y C 33.8355 -15.0446
24 C8y C 35.0480 -14.3446
25 C8x C 35.0480 -12.9446
26 C8x C 33.8424 -12.2485
27 C8x C 32.6300 -12.9485
28 O1a O 33.8356 -16.4498
29 C8y C 36.2792 -15.0556
30 C8x C 36.2790 -16.4499
31 C8x C 37.4913 -17.1501
32 C8x C 38.7038 -16.4502
33 C8y C 38.7040 -15.0560
34 C8x C 37.4917 -14.3558
35 C6a C 39.9237 -14.3521
36 O6a O 41.1172 -15.0416
37 O6a O 39.9240 -12.9502
38 N1a N 35.8702 -19.1003
39 C1b C 37.0869 -18.3978
40 C1b C 38.3036 -19.1003
41 O1a O 39.5203 -18.3978
BOND 42
1 5 6 2
2 6 7 1
3 7 8 1
4 8 9 1
5 5 9 1
6 8 10 2
7 9 11 1
8 11 12 1
9 13 14 1
10 7 14 2
11 6 15 1
12 11 16 2
13 16 17 1
14 17 18 2
15 18 19 1
16 12 19 2
17 13 20 1
18 19 21 1
19 18 22 1
20 20 23 2
21 23 24 1
22 24 25 2
23 25 26 1
24 26 27 2
25 20 27 1
26 23 28 1
27 24 29 1
28 29 30 2
29 30 31 1
30 31 32 2
31 32 33 1
32 33 34 2
33 29 34 1
34 33 35 1
35 35 36 1
36 35 37 2
37 1 2 1
38 2 3 1
39 3 4 1
40 38 39 1
41 39 40 1
42 40 41 1
BRACKET 1 33.8800 -19.8800 33.8800 -17.6400
1 40.8100 -17.6400 40.8100 -19.8800
1 2
ORIGINAL 1 1 2 3 4
REPEAT 1 38 39 40 41
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