KEGG   DRUG: Eltrombopag choline
Entry
D12815                      Drug                                   
Name
Eltrombopag choline;
Alvaiz (TN)
Product
ALVAIZ (Teva Pharmaceuticals)
  Generic
ELTROMBOPAG (Camber Pharmaceuticals)
Formula
C25H21N4O4. C5H14NO
Exact mass
545.2638
Mol weight
545.63
Structure
Remark
ATC code: B02BX05
Chemical structure group: DG03297
Product (DG03297): D03978<JP/US> D12815<US>
Efficacy
Antithrombocytopenia, Thrombopoietin receptor agonist
  Disease
Immune thrombocytopenia [DS:H01240]
Aplastic anemia [DS:H01132]
Target
MPL (TPOR, CD110) [HSA:4352] [KO:K05082]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX05 Eltrombopag
      D12815  Eltrombopag choline <US>
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    MPL (TPOR, CD110)
     D12815  Eltrombopag choline <US>
Other DBs
CAS: 2336813-25-1
PubChem: 497621228
LinkDB
KCF data

ATOM        40
            1   N2x N    14.2874  -17.5068
            2   C2y C    15.6888  -17.5068
            3   C2y C    16.1093  -16.1754
            4   C5x C    14.9881  -15.3345
            5   N1y N    13.8669  -16.1754
            6   O5x O    14.9881  -13.9330
            7   C8y C    12.6056  -15.4746
            8   C8x C    11.4143  -16.1754
            9   N1b N    18.5619  -16.1754
            10  N2b N    17.3706  -15.4746
            11  C1a C    16.5297  -18.6280
            12  C8x C    12.6056  -14.0732
            13  C8x C    11.4143  -13.3724
            14  C8y C    10.2231  -14.0732
            15  C8y C    10.2231  -15.4746
            16  C8y C    19.7531  -15.4746
            17  C1a C     9.0318  -16.1754
            18  C1a C     9.0318  -13.3724
            19  C8y C    20.9444  -16.1754
            20  C8y C    22.2057  -15.4746
            21  C8x C    22.2057  -14.0732
            22  C8x C    20.9444  -13.3724
            23  C8x C    19.7531  -14.0732
            24  O1a O    20.9444  -17.5768
            25  C8y C    23.3969  -16.1754
            26  C8x C    23.3969  -17.5768
            27  C8x C    24.6583  -18.2776
            28  C8x C    25.8495  -17.5768
            29  C8y C    25.8495  -16.1754
            30  C8x C    24.6583  -15.4746
            31  C6a C    27.0408  -15.4746
            32  O6a O    28.2320  -16.1754 #-
            33  O6a O    27.0408  -14.0732
            34  C1a C    31.1013  -16.2516
            35  N1d N    32.2937  -15.5502 #+
            36  C1b C    33.5562  -16.2516
            37  C1b C    34.7486  -15.5502
            38  O1a O    35.9409  -16.2516
            39  C1a C    32.2937  -14.1474
            40  C1a C    32.2937  -16.9530
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     4   6 2
            7     5   7 1
            8     7   8 1
            9     9  10 1
            10    3  10 2
            11    2  11 1
            12    7  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16    8  15 2
            17    9  16 1
            18   15  17 1
            19   14  18 1
            20   16  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   16  23 1
            26   19  24 1
            27   20  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   25  30 1
            34   29  31 1
            35   31  32 1
            36   31  33 2
            37   34  35 1
            38   35  36 1
            39   36  37 1
            40   37  38 1
            41   35  39 1
            42   35  40 1

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