KEGG   DRUG: Flunisolide acetate
Entry
D04214                      Drug                                   
Name
Flunisolide acetate (USAN)
Formula
C26H33FO7
Exact mass
476.221
Mol weight
476.5344
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: R01AD04 R03BA03
Chemical structure group: DG01040
Product (DG01040): D00324<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD04 Flunisolide
      D04214  Flunisolide acetate (USAN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA03 Flunisolide
      D04214  Flunisolide acetate (USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Flunisolide
    D04214  Flunisolide acetate (USAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG01040  Flunisolide
     D04214  Flunisolide acetate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01040  Flunisolide
     D04214  Flunisolide acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04214  Flunisolide acetate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04214
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG01040  Flunisolide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01040  Flunisolide
Other DBs
CAS: 4533-89-5
PubChem: 47206160
LigandBox: D04214
NIKKAJI: J297.803B
LinkDB
KCF data

ATOM        34
            1   C2x C    26.4600  -16.5900
            2   C5x C    26.4600  -17.9200
            3   C2x C    27.6500  -18.6200
            4   C2y C    28.8400  -17.9200
            5   C1z C    28.8400  -16.5900
            6   C2x C    27.6500  -15.8900
            7   C1y C    30.0300  -18.6200
            8   C1x C    31.2200  -17.9200
            9   C1y C    31.2200  -16.5900
            10  C1y C    30.0300  -15.8900
            11  C1y C    32.4800  -15.8900
            12  C1z C    32.4800  -14.4900
            13  C1x C    31.2200  -13.7900
            14  C1y C    30.0300  -14.4900
            15  C1x C    33.7400  -16.3100
            16  C1y C    34.5800  -15.1900
            17  C1z C    33.7400  -14.0700
            18  O5x O    25.2700  -18.6200
            19  C1a C    28.8400  -15.1900
            20  O1a O    28.8400  -13.7900
            21  C1a C    32.4800  -13.0900
            22  X   F    30.0300  -20.0200
            23  O2x O    35.9100  -14.7700
            24  C1z C    35.9100  -13.3700
            25  O2x O    34.5800  -12.9500
            26  C1a C    35.9100  -11.9700
            27  C1a C    37.3100  -13.3700
            28  C5a C    33.7400  -11.9700
            29  O5a O    35.0000  -11.2700
            30  C1b C    32.6200  -11.3400
            31  O7a O    31.4300  -11.9700
            32  C7a C    30.2441  -11.2260
            33  C1a C    29.0145  -11.8768
            34  O6a O    30.2266   -9.8011
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25    7  22 1 #Down
            26   16  23 1 #Down
            27   23  24 1
            28   24  25 1
            29   17  25 1 #Down
            30   24  26 1
            31   24  27 1
            32   17  28 1 #Up
            33   28  29 2
            34   28  30 1
            35   30  31 1
            36   31  32 1
            37   32  33 1
            38   32  34 2

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