KEGG   DRUG: FluocortoloneHelp
Entry
D04218                      Drug                                   

Name
Fluocortolone (USAN/INN)
Formula
C22H29FO4
Exact mass
376.205
Mol weight
376.4617
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: C05AA08 D07AC05 D07XC05 H02AB03
Chemical structure group: DG00295
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Comment
Prednisolone [DR:D00427] derivative
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA08 Fluocortolone
      D04218  Fluocortolone (USAN/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC05 Fluocortolone
      D04218  Fluocortolone (USAN/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC05 Fluocortolone
      D04218  Fluocortolone (USAN/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB03 Fluocortolone
      D04218  Fluocortolone (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04218  Fluocortolone (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 152-97-6
PubChem: 47206164
ChEMBL: CHEMBL251634
LigandBox: D04218
NIKKAJI: J5.871H
LinkDB All DBs
KCF data Show

ATOM        27
            1   C2x C    22.7424  -19.3415
            2   C5x C    22.7424  -20.6678
            3   C2x C    23.9291  -21.3658
            4   C2y C    25.1158  -20.6678
            5   C1z C    25.1158  -19.3415
            6   C2x C    23.9291  -18.6435
            7   C1y C    26.3722  -21.3658
            8   C1x C    27.5589  -20.6678
            9   C1y C    27.5589  -19.3415
            10  C1y C    26.3722  -18.6435
            11  C1y C    28.7456  -18.6435
            12  C1z C    28.7456  -17.2474
            13  C1x C    27.5589  -16.5494
            14  C1y C    26.3722  -17.2474
            15  O5x O    21.5558  -21.3658
            16  C1a C    25.1158  -17.9454
            17  O1a O    25.1158  -16.5494
            18  C1a C    28.7456  -15.8513
            19  X   F    26.3722  -22.7619
            20  C1x C    31.1704  -18.6435
            21  C1y C    31.1704  -17.2474
            22  C1y C    29.9580  -16.5474
            23  C1a C    32.3790  -16.5495
            24  C5a C    29.9579  -15.1200
            25  O5a O    28.7470  -14.4209
            26  C1b C    31.1719  -14.4191
            27  O1a O    32.3682  -15.1099
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    2  15 2
            18    5  16 1 #Up
            19   14  17 1 #Up
            20   12  18 1 #Up
            21    7  19 1 #Down
            22   11  20 1
            23   20  21 1
            24   21  22 1
            25   12  22 1
            26   21  23 1 #Down
            27   22  24 1 #Up
            28   24  25 2
            29   24  26 1
            30   26  27 1

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