KEGG   DRUG: Idursulfase
Entry
D04499                      Drug                                   
Name
Idursulfase (USAN/INN);
Idursulfase (genetical recombination) (JAN);
Elaprase (TN)
Product
ELAPRASE (Takeda Pharmaceuticals America)
Sequence
SETQANSTTD ALNVLLIIVD DLRPSLGCYG DKLVRSPNID QLASHSLLFQ NAFAQQAVCA
PSRVSFLTGR RPDTTRLYDF NSYWRVHAGN FSTIPQYFKE NGYVTMSVGK VFHPGISSNH
TDDSPYSWSF PPYHPSSEKY ENTKTCRGPD GELHANLLCP VDVLDVPEGT LPDKQSTEQA
IQLLEKMKTS ASPFFLAVGY HKPHIPFRYP KEFQKLYPLE NITLAPDPEV PDGLPPVAYN
PWMDIRQRED VQALNISVPY GPIPVDFQRK IRQSYFASVS YLDTQVGRLL SALDDLQLAN
STIIAFTSDH GWALGEHGEW AKYSNFDVAT HVPLIFYVPG RTASLPEAGE KLFPYLDPFD
SASQLMEPGR QSMDLVELVS LFPTLAGLAG LQVPPRCPVP SFHVELCREG KNLLKHFRFR
DLEEDPYLPG NPRELIAYSQ YPRPSDIPQW NSDKPSLKDI KIMGYSIRTI DYRYTVWVGF
NPDEFLANFS DIHAGELYFV DSDPLQDHNM YNDSQGGDLF QLLMP
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB09
Product: D04499<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (iduronate-2-sulfatase)
  Disease
Hunter syndrome [DS:H00129]
  Type
Enzyme replacement therapy product
Target
IDS* [HSA_VAR:3423v1] [HSA:3423] [KO:K01136]
  Pathway
hsa00531  Glycosaminoglycan degradation
hsa04142  Lysosome
  Network
nt06012  Glycosaminoglycan degradation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB09 Idursulfase
      D04499  Idursulfase (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Idursulfase
   D04499  Idursulfase (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D04499  Idursulfase (USAN/INN); Idursulfase (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Sulfatases
    IDS* [HSA_VAR:3423v1]
     D04499  Idursulfase (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04499
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04499
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04499
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04499
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D04499
Other DBs
CAS: 50936-59-9
PubChem: 47206347
LinkDB

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