Homo sapiens (human): 3423 Help Entry 3423              CDS       T01001                                  Symbol IDS, ID2S, MPS2, SIDS Name (RefSeq) iduronate 2-sulfatase   KO K01136   iduronate 2-sulfatase [EC:3.1.6.13] Organism hsa  Homo sapiens (human) Pathway hsa00531   Glycosaminoglycan degradation hsa01100   Metabolic pathways hsa04142   Lysosome Module hsa_M00076   Dermatan sulfate degradation hsa_M00078   Heparan sulfate degradation Network nt06012  Glycosaminoglycan degradation   Element N00610   Dermatan sulfate degradation N00615   Heparan sulfate degradation Disease H00129   Mucopolysaccharidosis type II H00421   Mucopolysaccharidosis Drug target Idursulfase:  D04499<JP/US> Idursulfase beta:  D11025<JP> Pabinafusp alfa:  D11812<JP> Tividenofusp alfa:  D12806 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09107 Glycan biosynthesis and metabolism    00531 Glycosaminoglycan degradation     3423 (IDS)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     3423 (IDS) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.6  Sulfuric-ester hydrolases     3.1.6.13  iduronate-2-sulfatase      3423 (IDS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Sulfatase Phosphodiest DUF229 Motif Other DBs NCBI-GeneID:  3423 NCBI-ProteinID:  NP_000193 OMIM:  300823 HGNC:  5389 Ensembl:  ENSG00000010404 UniProt:  P22304 Structure PDB LinkDB All DBs Position X:complement(149476988..149505306) Genome browser AA seq 550 aa AA seqDB search MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ GGDLFQLLMP NT seq 1653 nt NT seq  +upstreamnt  +downstreamnt atgccgccaccccggaccggccgaggccttctctggctgggtctggttctgagctccgtc tgcgtcgccctcggatccgaaacgcaggccaactcgaccacagatgctctgaacgttctt ctcatcatcgtggatgacctgcgcccctccctgggctgttatggggataagctggtgagg tccccaaatattgaccaactggcatcccacagcctcctcttccagaatgcctttgcgcag caagcagtgtgcgccccgagccgcgtttctttcctcactggcaggagacctgacaccacc cgcctgtacgacttcaactcctactggagggtgcacgctggaaacttctccaccatcccc cagtacttcaaggagaatggctatgtgaccatgtcggtgggaaaagtctttcaccctggg atatcttctaaccataccgatgattctccgtatagctggtcttttccaccttatcatcct tcctctgagaagtatgaaaacactaagacatgtcgagggccagatggagaactccatgcc aacctgctttgccctgtggatgtgctggatgttcccgagggcaccttgcctgacaaacag agcactgagcaagccatacagttgttggaaaagatgaaaacgtcagccagtcctttcttc ctggccgttgggtatcataagccacacatccccttcagataccccaaggaatttcagaag ttgtatcccttggagaacatcaccctggcccccgatcccgaggtccctgatggcctaccc cctgtggcctacaacccctggatggacatcaggcaacgggaagacgtccaagccttaaac atcagtgtgccgtatggtccaattcctgtggactttcagcggaaaatccgccagagctac tttgcctctgtgtcatatttggatacacaggtcggccgcctcttgagtgctttggacgat cttcagctggccaacagcaccatcattgcatttacctcggatcatgggtgggctctaggt gaacatggagaatgggccaaatacagcaattttgatgttgctacccatgttcccctgata ttctatgttcctggaaggacggcttcacttccggaggcaggcgagaagcttttcccttac ctcgacccttttgattccgcctcacagttgatggagccaggcaggcaatccatggacctt gtggaacttgtgtctctttttcccacgctggctggacttgcaggactgcaggttccacct cgctgccccgttccttcatttcacgttgagctgtgcagagaaggcaagaaccttctgaag cattttcgattccgtgacttggaagaggatccgtacctccctggtaatccccgtgaactg attgcctatagccagtatccccggccttcagacatccctcagtggaattctgacaagccg agtttaaaagatataaagatcatgggctattccatacgcaccatagactataggtatact gtgtgggttggcttcaatcctgatgaatttctagctaacttttctgacatccatgcaggg gaactgtattttgtggattctgacccattgcaggatcacaatatgtataatgattcccaa ggtggagatcttttccagttgttgatgccttga

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