KEGG   DRUG: Lurasidone hydrochloride
Entry
D04820                      Drug                                   
Name
Lurasidone hydrochloride (JAN/USAN);
SM 13496;
Latuda (TN)
Product
  Generic
LURASIDONE HYDROCHLORIDE (A-S Medication Solutions), LURASIDONE HYDROCHLORIDE (A-S Medication Solutions), LURASIDONE HYDROCHLORIDE (Accord Healthcare), LURASIDONE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), LURASIDONE HYDROCHLORIDE (Alembic Pharmaceuticals), LURASIDONE HYDROCHLORIDE (American Health Packaging), LURASIDONE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), LURASIDONE HYDROCHLORIDE (Ascend Laboratories), LURASIDONE HYDROCHLORIDE (Aurobindo Pharma Limited), LURASIDONE HYDROCHLORIDE (Cipla USA), LURASIDONE HYDROCHLORIDE (Dr. Reddys Laboratories), LURASIDONE HYDROCHLORIDE (Dr. Reddys Laboratories), LURASIDONE HYDROCHLORIDE (Exelan Pharmaceuticals), LURASIDONE HYDROCHLORIDE (Golden State Medical Supply), LURASIDONE HYDROCHLORIDE (Lupin Pharmaceuticals), LURASIDONE HYDROCHLORIDE (MAJOR PHARMACEUTICALS), LURASIDONE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), LURASIDONE HYDROCHLORIDE (Major Pharmaceuticals), LURASIDONE HYDROCHLORIDE (Novadoz Pharmaceuticals LLC), LURASIDONE HYDROCHLORIDE (Proficient Rx LP), LURASIDONE HYDROCHLORIDE (REMEDYREPACK), LURASIDONE HYDROCHLORIDE (REMEDYREPACK), LURASIDONE HYDROCHLORIDE (REMEDYREPACK), LURASIDONE HYDROCHLORIDE (REMEDYREPACK), LURASIDONE HYDROCHLORIDE (REMEDYREPACK), LURASIDONE HYDROCHLORIDE (Slate Run Pharmaceuticals), LURASIDONE HYDROCHLORIDE (Sun Pharmaceutical Industries), LURASIDONE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), LURASIDONE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), LURASIDONE HYDROCHLORIDE (Zydus Lifesciences Limited), LURASIDONE HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C28H36N4O2S. HCl
Exact mass
528.2326
Mol weight
529.137
Structure
Class
Neuropsychiatric agent
 DG01483  5-HT1A-receptor agonist
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N05AE05
Product: D04820<JP/US>
Efficacy
Antipsychotic, Serotonin receptor antagonist, Dopamine D2 receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder [DS:H01653]
Comment
atypical antipsychotic
Treatment of schizophrenia
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AE Indole derivatives
     N05AE05 Lurasidone
      D04820  Lurasidone hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Lurasidone
    D04820  Lurasidone hydrochloride (JAN/USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Lurasidone
    D04820  Lurasidone hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D04820  Lurasidone hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01483  5-HT1A-receptor agonist
   D04820  Lurasidone hydrochloride
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    D04820  Lurasidone hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04820  Lurasidone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D04820  Lurasidone hydrochloride (JAN/USAN) <JP/US>
   Serotonin
    HTR2A
     D04820  Lurasidone hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04820
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04820
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04820
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04820
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04820
Other DBs
CAS: 367514-88-3
PubChem: 47206606
ChEBI: 70732
LigandBox: D04820
LinkDB
KCF data

ATOM        36
            1   C1y C    32.7876  -16.5933
            2   C1x C    33.4857  -15.3366
            3   C1x C    32.7178  -14.1498
            4   C1x C    31.3215  -14.1496
            5   C1x C    30.6931  -15.4064
            6   C1y C    31.3913  -16.5933
            7   C1x C    39.5595  -17.0122
            8   C1x C    39.5595  -18.4085
            9   C1y C    38.3029  -19.1066
            10  C1y C    37.0462  -18.4085
            11  C1y C    37.0462  -17.0122
            12  C1y C    38.2331  -16.3140
            13  C5x C    35.7896  -18.8273
            14  N1y N    34.8820  -17.7801
            15  C5x C    35.7198  -16.5933
            16  O5x O    35.3707  -15.2668
            17  O5x O    35.3707  -20.1538
            18  C1x C    37.8840  -17.6405
            19  C1b C    33.5555  -17.7801
            20  C1b C    30.7630  -17.7801
            21  N1y N    29.3667  -17.7799
            22  C1x C    28.6685  -16.5931
            23  C1x C    27.2722  -16.5931
            24  N1y N    26.5741  -17.8498
            25  C1x C    27.3421  -19.0366
            26  C1x C    28.7383  -19.0368
            27  C8y C    25.1778  -17.8498
            28  C8y C    24.3401  -16.7327
            29  C8y C    23.0136  -17.2214
            30  S2x S    23.0136  -18.6177
            31  N5x N    24.4099  -19.0366
            32  C8x C    24.6193  -15.3364
            33  C8x C    23.5721  -14.4289
            34  C8x C    22.2456  -14.9176
            35  C8x C    21.9664  -16.3138
            36  X   Cl   42.2125  -17.9198
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12    7  12 1
            13   13  14 1
            14   14  15 1
            15   11  15 1
            16   15  16 2
            17   13  17 2
            18   12  18 1 #Up
            19    9  18 1 #Up
            20   10  13 1
            21   14  19 1
            22    1  19 1 #Up
            23    6  20 1 #Down
            24   20  21 1
            25   21  22 1
            26   22  23 1
            27   23  24 1
            28   24  25 1
            29   25  26 1
            30   21  26 1
            31   24  27 1
            32   27  28 1
            33   28  29 1
            34   29  30 1
            35   30  31 1
            36   27  31 2
            37   28  32 2
            38   32  33 1
            39   33  34 2
            40   34  35 1
            41   29  35 2

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