| Entry |
|
|---|
| Name |
Mefloquine (USAN/INN) |
|---|
| Formula |
C17H16F6N2O
|
|---|
| Exact mass |
378.1167
|
|---|
| Mol weight |
378.31
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01020): | D00831<JP/US> |
|
|---|
| Efficacy |
Antimalarial |
|---|
| Comment |
Methanolquinoline
|
|---|
| Metabolism |
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01B ANTIMALARIALS
P01BC Methanolquinolines
P01BC02 Mefloquine
D04895 Mefloquine (USAN/INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01020 Mefloquine
D04895 Mefloquine
Antimicrobials [BR:br08307]
Antiparasitics
Antmalarials
Methanolquinoline
D04895 Mefloquine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04895
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01020 Mefloquine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C8y C 17.5956 -17.6229
2 C8y C 17.5490 -16.2269
3 C8y C 16.2989 -18.3064
4 N5x N 18.7231 -18.3413
5 C8y C 18.7641 -15.5492
6 C8x C 16.3457 -15.5024
7 C8x C 15.0956 -17.5879
8 C1d C 16.2873 -19.7025
9 C8y C 19.9440 -17.6580
10 C8x C 19.9616 -16.2619
11 C1c C 18.7465 -14.1472
12 C8x C 15.1130 -16.1801
13 X F 14.8853 -19.6966
14 X F 17.6833 -19.7025
15 X F 16.2756 -21.1045
16 C1d C 21.1416 -18.3706
17 C1y C 19.9616 -13.4462
18 O1a O 17.5315 -13.4519
19 X F 22.3450 -19.0717
20 X F 21.8308 -17.1555
21 X F 20.4348 -19.5798
22 C1x C 21.1767 -14.1472
23 N1x N 19.9616 -12.0442
24 C1x C 22.3916 -13.4402
25 C1x C 21.1767 -11.3432
26 C1x C 22.3916 -12.0384
BOND 28
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 2
9 5 10 2
10 5 11 1
11 6 12 2
12 8 13 1
13 8 14 1
14 8 15 1
15 9 16 1
16 11 17 1
17 11 18 1 #Down
18 16 19 1
19 16 20 1
20 16 21 1
21 17 22 1
22 17 23 1
23 22 24 1
24 23 25 1
25 24 26 1
26 7 12 1
27 9 10 1
28 25 26 1
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