KEGG   DRUG: Memantine hydrochloride
Entry
D04905                      Drug                                   
Name
Memantine hydrochloride (JAN/USP);
Namenda (TN);
Memary (TN)
Product
  Generic
MEMANTINE (American Health Packaging), MEMANTINE (Apotex Corp.), MEMANTINE (Cardinal Health 107), MEMANTINE (Chartwell RX), MEMANTINE (Dr. Reddys Laboratories Limited), MEMANTINE (Major Pharmaceuticals), MEMANTINE (NCS HealthCare of KY), MEMANTINE (NCS HealthCare of KY), MEMANTINE (NorthStar RxLLC), MEMANTINE HYDROCHLORIDE (A-S Medication Solutions), MEMANTINE HYDROCHLORIDE (A-S Medication Solutions), MEMANTINE HYDROCHLORIDE (A-S Medication Solutions), MEMANTINE HYDROCHLORIDE (A-S Medication Solutions), MEMANTINE HYDROCHLORIDE (A-S Medication Solutions), MEMANTINE HYDROCHLORIDE (Actavis Pharma), MEMANTINE HYDROCHLORIDE (Ajanta Pharma USA), MEMANTINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Alembic Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), MEMANTINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MEMANTINE HYDROCHLORIDE (Aurobindo Pharma Limited), MEMANTINE HYDROCHLORIDE (Aurobindo Pharma Limited), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (Bryant Ranch Prepack), MEMANTINE HYDROCHLORIDE (CELLTRION USA), MEMANTINE HYDROCHLORIDE (Camber Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Chartwell RX), MEMANTINE HYDROCHLORIDE (DirectRx), MEMANTINE HYDROCHLORIDE (Lannett Company), MEMANTINE HYDROCHLORIDE (Lannett Company), MEMANTINE HYDROCHLORIDE (Lupin Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Lupin Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Major Pharmaceuticals), MEMANTINE HYDROCHLORIDE (NCS HealthCare of KY), MEMANTINE HYDROCHLORIDE (POLYGEN PHARMACEUTICALS), MEMANTINE HYDROCHLORIDE (Preferred Pharmaceuticals), MEMANTINE HYDROCHLORIDE (REMEDYREPACK), MEMANTINE HYDROCHLORIDE (Seton Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Slate Run Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Strides Pharma Science Limited), MEMANTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), MEMANTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), MEMANTINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), MEMANTINE HYDROCHLORIDE (Upsher-Smith Laboratories), MEMANTINE HYDROCHLORIDE (Viona Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Vitruvias Therapeutics), MEMANTINE HYDROCHLORIDE (Zydus Lifesciences Limited), MEMANTINE HYDROCHLORIDE (Zydus Lifesciences Limited), MEMANTINE HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C12H21N. HCl
Exact mass
215.1441
Mol weight
215.7628
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01968  Antidementia agent
Transporter substrate
 DG02854  SLC22A2 substrate
Remark
Therapeutic category: 1190
ATC code: N06DX01
Chemical structure group: DG00986
Product (DG00986): D04905<JP/US>
Product (mixture): D11387<US>
Efficacy
Dementia therapeutic agent, NMDA receptor antagonist
  Disease
Dementia of the Alzheimer's type [DS:H00056]
Comment
Adamantane derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07235  N-Methyl-D-aspartic acid (NMDA) receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX01 Memantine
      D04905  Memantine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  N-methyl-D-aspartate (NMDA) Receptor Antagonist
   Memantine
    D04905  Memantine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D04905  Memantine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01498  NMDA receptor antagonist
   DG00986  Memantine
    D04905  Memantine hydrochloride
  DG01968  Antidementia agent
   DG00986  Memantine
    D04905  Memantine hydrochloride
 Transporter substrate
  DG02854  SLC22A2 substrate
   DG00986  Memantine
    D04905  Memantine hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D04905  Memantine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D04905  Memantine hydrochloride (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04905
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04905
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04905
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04905
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D04905
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01498  NMDA receptor antagonist
   DG00986  Memantine
  DG01968  Antidementia agent
   DG00986  Memantine
 Transporter substrate
  DG02854  SLC22A2 substrate
   DG00986  Memantine
Other DBs
CAS: 41100-52-1
PubChem: 47206665
ChEBI: 64323
LigandBox: D04905
NIKKAJI: J299.313I
LinkDB
KCF data

ATOM        14
            1   C1x C    24.5248  -18.7456
            2   C1z C    24.5248  -20.1058
            3   C1x C    25.7055  -20.7858
            4   C1z C    26.8792  -20.1058
            5   C1x C    26.8792  -18.7456
            6   C1z C    25.7055  -18.0656
            7   C1x C    23.5563  -21.0675
            8   C1y C    24.9163  -21.0675
            9   C1x C    26.2284  -21.4178
            10  C1a C    28.1860  -20.4561
            11  C1a C    23.2060  -20.4561
            12  N1a N    25.7073  -16.7056
            13  C1x C    24.9096  -19.4326
            14  X   Cl   32.0600  -19.7400
BOND        15
            1     2   7 1
            2     1   2 1
            3     7   8 1
            4     2   3 1
            5     8   9 1
            6     9   4 1
            7     3   4 1
            8     4  10 1
            9     4   5 1
            10    2  11 1
            11    5   6 1
            12    6  12 1
            13    6   1 1
            14    8  13 1
            15    6  13 1

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