KEGG   DRUG: MetforminHelp
Entry
D04966                      Drug                                   

Name
Metformin (USAN/INN)
Formula
C4H11N5
Exact mass
129.1014
Mol weight
129.1636
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Same as: C07151
ATC code: A10BA02
Chemical structure group: DG00113
Product (DG00113): D00944<JP/US>
Product (mixture): D09744<JP/US> D10586<US> D10752<US> D10587<US> D11067<US>
Efficacy
Antidiabetic, Hypoglycemic, AMP kinase activator
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D04966  Metformin (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Metformin
    D04966  Metformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMKL family
    AMPK (PRKAA)
     D04966  Metformin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 657-24-9
PubChem: 47206702
ChEBI: 6801
ChEMBL: CHEMBL1431
DrugBank: DB00331
PDB-CCD: MF8[PDBj]
LigandBox: D04966
NIKKAJI: J9.463C
LinkDB All DBs
KCF data Show

ATOM        9
            1   C2c C    26.2960  -19.4016
            2   N1b N    25.0898  -18.7081
            3   N1c N    27.5139  -18.7081
            4   N2a N    26.2960  -20.8058
            5   C2c C    23.8721  -19.4016
            6   C1a C    28.7260  -19.4016
            7   C1a C    27.5139  -17.3038
            8   N1a N    22.6600  -18.7081
            9   N2a N    23.8721  -20.8058
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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