| Entry |
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| Symbol |
PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA
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| Name |
(RefSeq) protein kinase AMP-activated catalytic subunit alpha 2
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| KO |
| K07198 | 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] |
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| Organism |
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| Pathway |
| hsa04213 | Longevity regulating pathway - multiple species |
| hsa04920 | Adipocytokine signaling pathway |
| hsa04932 | Non-alcoholic fatty liver disease |
| hsa05418 | Fluid shear stress and atherosclerosis |
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| Network |
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| Element |
| N01576 | STRAD/STK11- TSC signaling pathway |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
5563 (PRKAA2)
04068 FoxO signaling pathway
5563 (PRKAA2)
04151 PI3K-Akt signaling pathway
5563 (PRKAA2)
04152 AMPK signaling pathway
5563 (PRKAA2)
04150 mTOR signaling pathway
5563 (PRKAA2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5563 (PRKAA2)
09144 Cellular community - eukaryotes
04530 Tight junction
5563 (PRKAA2)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
5563 (PRKAA2)
04922 Glucagon signaling pathway
5563 (PRKAA2)
04920 Adipocytokine signaling pathway
5563 (PRKAA2)
04921 Oxytocin signaling pathway
5563 (PRKAA2)
09149 Aging
04211 Longevity regulating pathway
5563 (PRKAA2)
04213 Longevity regulating pathway - multiple species
5563 (PRKAA2)
09159 Environmental adaptation
04710 Circadian rhythm
5563 (PRKAA2)
04714 Thermogenesis
5563 (PRKAA2)
09160 Human Diseases
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
5563 (PRKAA2)
05410 Hypertrophic cardiomyopathy
5563 (PRKAA2)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
5563 (PRKAA2)
04932 Non-alcoholic fatty liver disease
5563 (PRKAA2)
04931 Insulin resistance
5563 (PRKAA2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5563 (PRKAA2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
5563 (PRKAA2)
03029 Mitochondrial biogenesis [BR:hsa03029]
5563 (PRKAA2)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
5563 (PRKAA2)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CAMK group
CAMKL family
5563 (PRKAA2)
Membrane trafficking [BR:hsa04131]
Autophagy
Other autophagy associated proteins
Others
5563 (PRKAA2)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Other regulator of mitochondrial biogenesis
5563 (PRKAA2)
Mitophagy factors
Other mitophagy factors
5563 (PRKAA2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
1:56645314..56715335
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| AA seq |
552 aa
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR |
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| NT seq |
1659 nt +upstreamnt +downstreamnt
atggctgagaagcagaagcacgacgggcgggtgaagatcggacactacgtgctgggcgac
acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattaacaggccat
aaagtggcagttaaaatcttaaatagacagaagattcgcagtttagatgttgttggaaaa
ataaaacgagaaattcaaaatctaaaactctttcgtcatcctcatattatcaaactatac
caggtgatcagcactccaacagatttttttatggtaatggaatatgtgtctggaggtgaa
ttatttgactacatctgtaagcatggacgggttgaagagatggaagccaggcggctcttt
cagcagattctgtctgctgtggattactgtcataggcatatggttgttcatcgagacctg
aaaccagagaatgtcctgttggatgcacacatgaatgccaagatagccgatttcggatta
tctaatatgatgtcagatggtgaatttctgagaactagttgcggatctccaaattatgca
gcacctgaagtcatctcaggcagattgtatgcaggtcctgaagttgatatctggagctgt
ggtgttatcttgtatgctcttctttgtggcaccctcccatttgatgatgagcatgtacct
acgttatttaagaagatccgagggggtgtcttttatatcccagaatatctcaatcgttct
gtcgccactctcctgatgcatatgctgcaggttgacccactgaaacgagcaactatcaaa
gacataagagagcatgaatggtttaaacaagatttgcccagttacttatttcctgaagac
ccttcctatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt
gaatgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaagaccagctt
gcagtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc
tacctcgcctctagtcctccatctggttcttttatggatgatagtgccatgcatattccc
ccaggcctgaaacctcatccagaaaggatgccacctcttatagcagacagccccaaagca
agatgtccattggatgcactgaatacgactaagcccaaatctttagctgtgaaaaaagcc
aagtggcatcttggaatccgaagtcagagcaaaccgtatgacattatggctgaagtttac
cgagctatgaagcagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta
agaagaaaaaatccagtgactggcaattacgtgaaaatgagcttacaactttacctggtt
gataacaggagctatcttttggactttaaaagcattgatgatgaagtagtggagcagaga
tctggttcctcaacacctcagcgttcctgttctgctgctggcttacacagaccaagatca
agttttgattccacaactgcagagagccattcactttctggctctctcactggctctttg
accggaagcacattgtcttcagtttcacctcgcctgggcagtcacaccatggattttttt
gaaatgtgtgccagtctgattactactttagcccgttga |
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