KEGG   DRUG: Pazufloxacin mesilateHelp
Entry
D05382                      Drug                                   

Name
Pazufloxacin mesilate (JAN);
Pasil (TN)
Formula
C16H15FN2O4. CH4SO3
Exact mass
414.0897
Mol weight
414.4054
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Therapeutic category: 6241
ATC code: J01MA18
Chemical structure group: DG00629
Product (DG00629): D05382<JP>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
topoisomerase IV [KO:K02621 K02622]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA18 Pazufloxacin
      D05382  Pazufloxacin mesilate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D05382  Pazufloxacin mesilate (JAN)
Antiinfectives [br08350.html]
 Antibacterials
  D05382
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05382
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05382
BRITE hierarchy
Other DBs
PubChem: 47207058
LigandBox: D05382
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1x C     5.4862   -9.9649
            2   C1z C     6.1845   -8.7079
            3   C1x C     6.8828   -9.9649
            4   C8y C     7.3716   -8.0097
            5   N1a N     4.9974   -8.0097
            6   O2x O     8.5587  -10.1743
            7   C1y C    10.9329  -10.1743
            8   C1x C     9.7458  -10.8726
            9   C8y C     8.5587   -8.7778
            10  C8y C     7.3716   -6.6131
            11  C8x C     8.5587   -5.9148
            12  N4y N    10.9329   -8.7778
            13  C8y C     9.7458   -8.0795
            14  C8y C     9.7458   -6.6829
            15  C8y C    10.9329   -5.9846
            16  C8y C    12.1898   -6.6829
            17  C8x C    12.1898   -8.0795
            18  C6a C    13.3769   -5.9846
            19  O6a O    13.3769   -4.5880
            20  O6a O    14.5640   -6.6829
            21  O5x O    10.9329   -4.5880
            22  X   F     6.1147   -5.9148
            23  C1a C    12.1898  -10.8726
            24  C1a C    16.3934   -9.7380
            25  S4a S    17.7940   -9.7380
            26  O1d O    17.7940  -11.1386
            27  O1d O    19.1946   -9.7380
            28  O1d O    17.7940   -8.3374
BOND        30
            1     4  10 1
            2    10  11 2
            3    11  14 1
            4     1   3 1
            5     3   2 1
            6     6   9 1
            7    12   7 1
            8     7   8 1
            9    12  13 1
            10   13  14 2
            11   14  15 1
            12   15  16 1
            13   16  17 2
            14   17  12 1
            15    8   6 1
            16   16  18 1
            17    4   2 1
            18   18  19 2
            19    1   2 1
            20   18  20 1
            21    2   5 1
            22   15  21 2
            23   13   9 1
            24   10  22 1
            25    9   4 2
            26    7  23 1 #Up
            27   24  25 1
            28   25  26 2
            29   25  27 1
            30   25  28 2

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