KEGG   DRUG: Pilocarpine nitrate
Entry
D05478                      Drug                                   

Name
Pilocarpine nitrate (USP);
Pilagan (TN)
Formula
C11H16N2O2. HNO3
Exact mass
271.1168
Mol weight
271.2698
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Other
 DG01719  Parasympathomimetic agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Miotic, Muscarinic acetylcholine receptor agonist
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D05478  Pilocarpine nitrate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D05478  Pilocarpine nitrate (USP)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Cholinergic Agonists, Ophthalmic
    Pilocarpine
     D05478  Pilocarpine nitrate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D05478  Pilocarpine nitrate (USP)
    CHRM3
     D05478  Pilocarpine nitrate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05478
Other DBs
CAS: 148-72-1
PubChem: 47207147
ChEMBL: CHEMBL1213136
DrugBank: DB01085
LigandBox: D05478
NIKKAJI: J262.833C
LinkDB
KCF data

ATOM        19
            1   C1y C    28.6049  -17.6741
            2   C1y C    27.1960  -17.6741
            3   C1b C    29.8268  -18.3174
            4   C1x C    29.0492  -16.3294
            5   C7x C    26.7576  -16.3294
            6   C1b C    26.3656  -18.8143
            7   C8y C    30.8967  -17.6799
            8   O7x O    27.9034  -15.4992
            9   O6a O    25.4128  -15.8909
            10  C1a C    24.9625  -18.8082
            11  N4y N    32.3115  -17.6799
            12  C8x C    30.4524  -16.3353
            13  C8x C    32.7443  -16.3353
            14  C1a C    33.1359  -18.8200
            15  N5x N    31.6043  -15.5050
            16  N2b N    37.8531  -17.0458 #+
            17  O3a O    37.8472  -15.6499
            18  O3a O    39.0961  -17.7559 #-
            19  O1b O    36.6419  -17.7522
BOND        19
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2
            17   16  17 2
            18   16  18 1
            19   16  19 1

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