KEGG   DRUG: Temozolomide
Entry
D06067                      Drug                                   
Name
Temozolomide (JP18/USAN/INN);
Temodal (TN);
Temodar (TN)
Product
TEMODAR (Merck Sharp & Dohme LLC)
  Generic
TEMOZOLOMIDE (Accord Healthcare), TEMOZOLOMIDE (Amneal Pharmaceuticals LLC), TEMOZOLOMIDE (Areva Pharmaceuticals), TEMOZOLOMIDE (Ascend Laboratories), TEMOZOLOMIDE (AvPAK), TEMOZOLOMIDE (Camber Pharmaceuticals), TEMOZOLOMIDE (Devatis), TEMOZOLOMIDE (Nivagen Pharmaceuticals), TEMOZOLOMIDE (Rising Pharma Holdings), TEMOZOLOMIDE (Sun Pharmaceutical Industries), TEMOZOLOMIDE (Zydus Lifesciences Limited), TEMOZOLOMIDE (Zydus Pharmaceuticals USA)
Formula
C6H6N6O2
Exact mass
194.0552
Mol weight
194.15
Structure
Class
Antineoplastic
 DG01677  Alkylating agent
Remark
Therapeutic category: 4219
ATC code: L01AX03
Product: D06067<JP/US>
Efficacy
Antineoplastic, Alkylating agent
  Disease
Glioblastoma [DS:H00042]
Anaplastic astrocytoma [DS:H00042]
Target
DNA
Interaction
Structure map
map07040  Antineoplastics - alkylating agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AX Other alkylating agents
     L01AX03 Temozolomide
      D06067  Temozolomide (JP18/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Alkylating Agents, Other
    Temozolomide
     D06067  Temozolomide (JP18/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   421  Alkylating agents
    4219  Others
     D06067  Temozolomide (JP18/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   D06067  Temozolomide
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D06067  Temozolomide
  D06067  Temozolomide capsules
  D06067  Temozolomide for injection
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06067
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06067
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06067
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06067
Other DBs
CAS: 85622-93-1
PubChem: 47207725
ChEBI: 72564
LigandBox: D06067
NIKKAJI: J171.234I
LinkDB
KCF data

ATOM        14
            1   N5x N    15.4700  -20.9300
            2   N4y N    15.4700  -22.3300
            3   C8y C    16.6824  -23.0300
            4   N4y N    17.8949  -22.3300
            5   C8y C    17.8949  -20.9300
            6   N5x N    16.6824  -20.2300
            7   C8x C    19.2264  -22.7626
            8   N5x N    20.0493  -21.6300
            9   C8y C    19.2264  -20.4974
            10  O5x O    16.6824  -24.4298
            11  C1a C    14.2576  -23.0300
            12  C5a C    19.6575  -19.1706
            13  O5a O    21.0369  -18.8774
            14  N1a N    18.7311  -18.1415
BOND        15
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 2
            11    3  10 2
            12    2  11 1
            13    9  12 1
            14   12  13 2
            15   12  14 1

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