KEGG   DRUG: Teriparatide
Entry
D06078                      Drug                                   
Name
Teriparatide (USP/INN);
Teriparatide (genetical recombination) (JAN);
Teriparatide (genetical recombination) [Teriparatide biosimilar 1] (JAN);
Forteo (TN)
Product
FORTEO (Eli Lilly and Company), TERIPARATIDE (Alvogen)
  Generic
TERIPARATIDE (Apotex Corp.), TERIPARATIDE (Prasco Laboratories)
Formula
C181H291N55O51S2
Exact mass
4115.1309
Mol weight
4117.72
Sequence
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
Asn Phe-OH
  Type
Peptide
Class
Hormonal agent
 DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
Musculo-skeletal system agent
 DG03232  Osteoporosis agent
Remark
Therapeutic category: 2439
ATC code: H05AA02
Chemical structure group: DG00512
Product (DG00512): D06078<JP/US> D03358<JP> D06546<US>
Efficacy
Antiresorptive, Osteoporosis agent, Parathyroid hormone receptor agonist
  Disease
Osteoporosis [DS:H01593]
Comment
Parathormone [CPD: C16051] analog
Target
PTH1R [HSA:5745] [KO:K04585]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
  Network
nt06318  CaSR-PTH signaling
Interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05A PARATHYROID HORMONES AND ANALOGUES
    H05AA Parathyroid hormones and analogues
     H05AA02 Teriparatide
      D06078  Teriparatide (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium Regulating Hormones
   Teriparatide
    D06078  Teriparatide (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2439  Others
     D06078  Teriparatide (USP/INN); Teriparatide (genetical recombination) (JAN); Teriparatide (genetical recombination) [Teriparatide biosimilar 1] (JAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
    D06078  Teriparatide
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
    D06078  Teriparatide
Drug classes [BR:br08332]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D06078  Teriparatide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Parathyroid hormone
    PTH1R
     D06078  Teriparatide (USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06078
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06078
Drug groups [BR:br08330]
 Hormonal agent
  DG01661  Parathyroid hormone and parathyroid hormone-related protein analog
   DG00512  Teriparatide
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG00512  Teriparatide
Other DBs
CAS: 52232-67-4
PubChem: 47207736
NIKKAJI: J2.191.211E
LinkDB

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