KEGG   DRUG: Vernakalant hydrochloride
Entry
D06665                      Drug                                   
Name
Vernakalant hydrochloride (USAN)
Formula
C20H31NO4. HCl
Exact mass
385.2020
Mol weight
385.92
Structure
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01648  Class III antiarrhythmic agent
Remark
ATC code: C01BG11
Efficacy
Antiarrhythmic
Comment
Treatment of patients with atrial fibrillation and atrial flutter
Target
KCNA5 [HSA:3741] [KO:K04878]
KCND3 [HSA:3752] [KO:K04893]
SCN5A [HSA:6331] [KO:K04838]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG11 Vernakalant
      D06665  Vernakalant hydrochloride (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01648  Class III antiarrhythmic agent
    D06665  Vernakalant hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN5A
     D06665  Vernakalant hydrochloride (USAN)
   Potassium channels
    KCNA5
     D06665  Vernakalant hydrochloride (USAN)
    KCND3
     D06665  Vernakalant hydrochloride (USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06665
Other DBs
CAS: 748810-28-8
PubChem: 47208316
LigandBox: D06665
LinkDB
KCF data

ATOM        26
            1   C8y C    17.2900  -11.7600
            2   C8y C    17.2900  -13.1600
            3   C8x C    18.5024  -13.8600
            4   C8y C    19.7149  -13.1600
            5   C8x C    19.7149  -11.7600
            6   C8x C    18.5024  -11.0600
            7   O2a O    16.0776  -11.0600
            8   C1a C    14.8821  -11.7504
            9   C1b C    20.9460  -13.8710
            10  C1b C    22.1512  -13.1753
            11  O2a O    23.3335  -13.8581
            12  C1y C    24.5275  -13.1688
            13  O2a O    16.0776  -13.8600
            14  C1a C    14.8821  -13.1696
            15  C1y C    25.7154  -13.8548
            16  C1x C    26.9279  -13.1549
            17  C1x C    26.9280  -11.7549
            18  C1x C    25.7401  -11.0689
            19  C1x C    24.5276  -11.7688
            20  N1y N    25.7154  -15.2598
            21  C1x C    24.5662  -16.0949
            22  C1y C    25.0054  -17.4460
            23  C1x C    26.4260  -17.4458
            24  C1x C    26.8648  -16.0946
            25  O1a O    24.1850  -18.5754
            26  X   Cl   30.3800  -14.7000
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   12  11 1 #Down
            13    2  13 1
            14   13  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   12  19 1
            21   15  20 1 #Up
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   20  24 1
            27   22  25 1 #Up

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