KEGG   DRUG: Rivaroxaban
Entry
D07086                      Drug                                   
Name
Rivaroxaban (JAN/USAN/INN);
Xarelto (TN)
Product
XARELTO (A-S Medication Solutions), XARELTO (A-S Medication Solutions), XARELTO (A-S Medication Solutions), XARELTO (A-S Medication Solutions), XARELTO (Aphena Pharma Solutions - Tennessee), XARELTO (Cardinal Health 107), XARELTO (Janssen Pharmaceuticals)
Formula
C19H18ClN3O5S
Exact mass
435.0656
Mol weight
435.88
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
  DG03320  Direct oral anticoagulant (DOAC)
Metabolizing enzyme substrate
 DG02954  CYP2J2 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 3339
ATC code: B01AF01
Product: D07086<JP/US>
Efficacy
Antithrombotic, Factor Xa inhibitor
Comment
Prophylaxis of venous thromboembolism
Target
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2J2 [HSA:1573]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AF Direct factor Xa inhibitors
     B01AF01 Rivaroxaban
      D07086  Rivaroxaban (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Factor Xa Inhibitors, Direct
    Rivaroxaban
     D07086  Rivaroxaban (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3339  Others
     D07086  Rivaroxaban (JAN/USAN/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01662  Factor Xa inhibitor
    D07086  Rivaroxaban
   DG03320  Direct oral anticoagulant (DOAC)
    D07086  Rivaroxaban
 Metabolizing enzyme substrate
  DG02954  CYP2J2 substrate
   D07086  Rivaroxaban
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D07086  Rivaroxaban
 Transporter substrate
  DG01665  ABCB1 substrate
   D07086  Rivaroxaban
  DG01913  ABCG2 substrate
   D07086  Rivaroxaban
Drug classes [BR:br08332]
 Anticoagulant
  DG03320  Direct oral anticoagulant (DOAC)
   D07086  Rivaroxaban
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F10
     D07086  Rivaroxaban (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07086
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07086
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07086
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07086
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07086
 Drug transporters
  D07086
Other DBs
CAS: 366789-02-8
PubChem: 51091428
ChEBI: 68579
PDB-CCD: RIV[PDBj]
LigandBox: D07086
NIKKAJI: J2.395.184C
LinkDB
KCF data

ATOM        29
            1   O2x O    18.3529  -15.4520
            2   C1x C    18.3529  -16.8479
            3   C5x C    19.5395  -17.5459
            4   N1y N    20.7958  -16.8479
            5   C1x C    20.7958  -15.4520
            6   C1x C    19.5395  -14.7541
            7   C8y C    21.9824  -17.5459
            8   C8x C    21.9824  -18.9418
            9   C8x C    23.2387  -19.6397
            10  C8y C    24.4253  -18.9418
            11  C8x C    24.4253  -17.5459
            12  C8x C    23.2387  -16.8479
            13  N1y N    25.6118  -19.6397
            14  O5x O    19.5395  -18.9418
            15  C1x C    26.0493  -20.9654
            16  C1y C    27.4451  -21.0290
            17  O7x O    27.8704  -19.6295
            18  C7x C    26.7374  -18.8141
            19  O6a O    26.7311  -17.4063
            20  C1b C    28.2675  -22.0802
            21  N1b N    29.6596  -22.1153
            22  C5a C    30.4027  -20.9007
            23  C8y C    31.8236  -20.9466
            24  O5a O    29.7142  -19.6963
            25  S2x S    32.9956  -21.6562
            26  C8y C    34.1000  -20.7785
            27  C8x C    33.6066  -19.4570
            28  C8x C    32.1973  -19.4479
            29  X   Cl   35.4112  -21.1422
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15    3  14 2
            16   13  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21   18  19 2
            22   16  20 1 #Up
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 2
            27   23  25 1
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2
            32   26  29 1

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