KEGG   DRUG: Buprenorphine
Entry
D07132                      Drug                                   
Name
Buprenorphine (JAN/INN);
Temgesic (TN)
Product
BRIXADI (Braeburn), BUTRANS (Purdue Pharma LP), SUBLOCADE (Indivior)
  Generic
BUPRENORPHINE (Amneal Pharmaceuticals NY LLC), BUPRENORPHINE (INGENUS PHARMACEUTICALS), BUPRENORPHINE (Rhodes Pharmaceuticals L.P.), BUPRENORPHINE (Teva Pharmaceuticals USA), BUPRENORPHINE TRANSDERMAL SYSTEM (Alvogen)
Formula
C29H41NO4
Exact mass
467.3036
Mol weight
467.64
Structure
Simcomp
Class
Analgesic
 DG01984  Opioid analgesics
 DG01586  Opioid receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C08007
Therapeutic category: 1149
ATC code: N02AE01 N07BC01
Chemical structure group: DG00820
Product (DG00820): D07132<JP/US> D00836<JP/US>
Product (mixture): D10250<US>
Efficacy
Analgesic, Opioid receptor agonist/antagonist
Comment
Morphinan derivative, Oripavine derivative
Target
OPRK1 [HSA:4986] [KO:K04214]
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AE Oripavine derivatives
     N02AE01 Buprenorphine
      D07132  Buprenorphine (JAN/INN) <JP/US>
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC01 Buprenorphine
      D07132  Buprenorphine (JAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Buprenorphine
    D07132  Buprenorphine (JAN/INN)
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence
   Buprenorphine
    D07132  Buprenorphine (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D07132  Buprenorphine (JAN/INN)
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
    D07132  Buprenorphine
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
    D07132  Buprenorphine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
     D07132  Buprenorphine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07132  Buprenorphine (JAN/INN) <JP/US>
    OPRK1
     D07132  Buprenorphine (JAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07132
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07132
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07132
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07132
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D07132
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
Other DBs
CAS: 52485-79-7
PubChem: 51091471
ChEBI: 3216
LigandBox: D07132
NIKKAJI: J291.229E
LinkDB
KCF data

ATOM        34
            1   C1z C    16.5998  -15.1247
            2   C1z C    17.7863  -15.8227
            3   C1y C    15.4132  -15.8227
            4   C8y C    16.5998  -13.7986
            5   C1x C    17.7863  -14.4267
            6   C1y C    18.9729  -15.1247
            7   C1x C    17.7863  -17.2186
            8   C1x C    17.2280  -16.8697
            9   C1z C    15.4132  -17.1488
            10  O2x O    14.7851  -14.2872
            11  C8y C    15.4830  -13.1006
            12  C8y C    17.8561  -13.1006
            13  C1x C    20.1595  -14.4267
            14  N1y N    20.1595  -15.8227
            15  C1x C    18.9727  -13.7986
            16  C1y C    16.5998  -17.8468
            17  C1x C    16.0414  -16.1717
            18  C8y C    15.4830  -11.7047
            19  C8x C    17.8561  -11.7047
            20  C1b C    21.3460  -15.1945
            21  C8x C    16.6696  -11.0067
            22  O1a O    14.2965  -11.0067
            23  C1y C    22.5326  -15.8925
            24  C1x C    23.2305  -17.0790
            25  C1x C    23.9285  -15.8925
            26  O2a O    14.0173  -17.1488
            27  C1a C    13.3193  -15.9400
            28  C1d C    17.2978  -19.0557
            29  C1a C    18.6935  -19.0557
            30  C1d C    16.6094  -20.2477
            31  O1a O    17.9861  -20.2478
            32  C1a C    15.2041  -20.2478
            33  C1a C    17.2930  -21.4316
            34  C1a C    15.7619  -21.4443
BOND        40
            1     1   5 1 #Up
            2     2   6 1
            3     2   7 1
            4     2   8 1 #Down
            5     3   9 1
            6     3  10 1 #Down
            7     4  11 1
            8     4  12 2
            9     5  13 1
            10    6  14 1 #Up
            11    6  15 1
            12    7  16 1
            13    8  17 1
            14   11  18 2
            15   12  19 1
            16   14  20 1
            17   18  21 1
            18   18  22 1
            19    9  16 1
            20    9  17 1 #Down
            21   10  11 1
            22   12  15 1
            23   14  13 1 #Up
            24   19  21 2
            25    1   2 1
            26   20  23 1
            27    1   3 1
            28    1   4 1
            29   23  24 1
            30   23  25 1
            31   25  24 1
            32    9  26 1
            33   26  27 1
            34   16  28 1
            35   28  29 1 #Up
            36   28  30 1
            37   28  31 1 #Down
            38   30  32 1
            39   30  33 1
            40   30  34 1

» Japanese version   » Back

KEGG   DRUG: Buprenorphine hydrochloride
Entry
D00836                      Drug                                   
Name
Buprenorphine hydrochloride (JP18/USP);
Buprenex (TN)
Product
BELBUCA (BioDelivery Sciences International)
  Generic
BUPRENORPHINE (Actavis Pharma), BUPRENORPHINE (American Health Packaging), BUPRENORPHINE (AvPAK), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Clinical Solutions Wholesale), BUPRENORPHINE (Clinical Solutions Wholesale), BUPRENORPHINE (NuCare Pharmaceuticals), BUPRENORPHINE (RedPharm Drug), BUPRENORPHINE (Redpharm drug), BUPRENORPHINE (Rhodes Pharmaceuticals L.P.), BUPRENORPHINE (Sun Pharmaceutical Industries), BUPRENORPHINE HCL (Bryant Ranch Prepack), BUPRENORPHINE HCL (Clinical Solutions Wholesale), BUPRENORPHINE HCL (Hikma Pharmaceuticals USA), BUPRENORPHINE HCL (Major Pharmaceuticals), BUPRENORPHINE HCL (NuCare Pharmaceuticals), BUPRENORPHINE HCL (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (A-S Medication Solutions), BUPRENORPHINE HYDROCHLORIDE (Advagen Pharma), BUPRENORPHINE HYDROCHLORIDE (Akorn Operating Company LLC (dba Akorn)), BUPRENORPHINE HYDROCHLORIDE (ENDO USA), BUPRENORPHINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), BUPRENORPHINE HYDROCHLORIDE (Hospira), BUPRENORPHINE HYDROCHLORIDE (PAI Holdings), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE SUBLINGUAL (Direct_rx), BUPRENORPHINE SUBLINGUAL C-III (Direct_Rx)
Formula
C29H41NO4. HCl
Exact mass
503.2802
Mol weight
504.10
Structure
Simcomp
Class
Analgesic
 DG01984  Opioid analgesics
 DG01586  Opioid receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1149
ATC code: N02AE01 N07BC01
Chemical structure group: DG00820
Product (DG00820): D07132<JP/US> D00836<JP/US>
Product (mixture): D10250<US>
Efficacy
Analgesic, Opioid receptor agonist/antagonist
Comment
Morphinan derivative, Oripavine derivative
Target
OPRK1 [HSA:4986] [KO:K04214]
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AE Oripavine derivatives
     N02AE01 Buprenorphine
      D00836  Buprenorphine hydrochloride (JP18/USP) <JP/US>
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC01 Buprenorphine
      D00836  Buprenorphine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Buprenorphine
    D00836  Buprenorphine hydrochloride (JP18/USP)
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence
   Buprenorphine
    D00836  Buprenorphine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00836  Buprenorphine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
    D00836  Buprenorphine hydrochloride
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
    D00836  Buprenorphine hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
     D00836  Buprenorphine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00836  Buprenorphine hydrochloride (JP18/USP) <JP/US>
    OPRK1
     D00836  Buprenorphine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00836  Buprenorphine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00836
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
Other DBs
CAS: 53152-21-9
PubChem: 7847901
ChEBI: 652822
LigandBox: D00836
NIKKAJI: J299.733I
LinkDB
KCF data

ATOM        35
            1   X   Cl   23.5865  -20.2981
            2   C1z C    16.6051  -15.0621
            3   C1z C    17.7919  -15.7602
            4   C1y C    15.4182  -15.7602
            5   C8y C    16.6051  -13.7356
            6   C1x C    17.7919  -14.3639
            7   C1y C    18.9787  -15.0621
            8   C1x C    17.7919  -17.1565
            9   C1x C    17.2334  -16.8074
            10  C1z C    15.4182  -17.0867
            11  O2x O    14.7899  -14.2243
            12  C8y C    15.4880  -13.0375
            13  C8y C    17.8617  -13.0375
            14  C1x C    20.1656  -14.3639
            15  N1y N    20.1656  -15.7602
            16  C1x C    18.9785  -13.7356
            17  C1y C    16.6051  -17.7848
            18  C1x C    16.0466  -16.1093
            19  C8y C    15.4880  -11.6412
            20  C8x C    17.8617  -11.6412
            21  C1b C    21.3524  -15.1319
            22  C8x C    16.6749  -10.9431
            23  O1a O    14.3012  -10.9431
            24  C1y C    22.5392  -15.8300
            25  C1x C    23.2374  -17.0169
            26  C1x C    23.9355  -15.8300
            27  O2a O    14.0220  -17.0867
            28  C1a C    13.3238  -15.8998
            29  C1d C    17.3032  -18.9717
            30  C1a C    18.6995  -18.9717
            31  C1d C    16.6051  -20.1585
            32  O1a O    18.0013  -20.1585
            33  C1a C    15.2088  -20.1585
            34  C1a C    17.3032  -21.3453
            35  C1a C    15.7673  -21.4151
BOND        40
            1     2   6 1 #Up
            2     3   7 1
            3     3   8 1
            4     3   9 1 #Down
            5     4  10 1
            6     4  11 1 #Down
            7     5  12 1
            8     5  13 2
            9     6  14 1
            10    7  15 1 #Up
            11    7  16 1
            12    8  17 1
            13    9  18 1
            14   12  19 2
            15   13  20 1
            16   15  21 1
            17   19  22 1
            18   19  23 1
            19   10  17 1
            20   10  18 1 #Down
            21   11  12 1
            22   13  16 1
            23   15  14 1 #Up
            24   20  22 2
            25    2   3 1
            26   21  24 1
            27    2   4 1
            28    2   5 1
            29   24  25 1
            30   24  26 1
            31   26  25 1
            32   10  27 1
            33   27  28 1
            34   17  29 1
            35   29  30 1 #Up
            36   29  31 1
            37   29  32 1 #Down
            38   31  33 1
            39   31  34 1
            40   31  35 1

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