KEGG   DRUG: NorgestrienoneHelp
Entry
D07220                      Drug                                   

Name
Norgestrienone (INN)
Formula
C20H22O2
Exact mass
294.162
Mol weight
294.3875
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
ATC code: G03AC07
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC07 Norgestrienone
      D07220  Norgestrienone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D07220  Norgestrienone (INN)
BRITE hierarchy
Other DBs
CAS: 848-21-5
PubChem: 51091558
ChEMBL: CHEMBL1908319
LigandBox: D07220
NIKKAJI: J7.140D
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1z C    23.8000  -18.9700
            2   C1y C    23.8000  -20.3700
            3   C1x C    26.2249  -20.3700
            4   C1x C    26.2249  -18.9700
            5   C1z C    25.0124  -18.2700
            6   C2x C    22.5876  -18.2700
            7   C2x C    21.3751  -18.9700
            8   C2y C    21.3751  -20.3700
            9   C1y C    22.5876  -21.0700
            10  C2y C    20.1627  -21.0700
            11  C2y C    20.1627  -22.4700
            12  C1x C    21.3751  -23.1700
            13  C1x C    22.5875  -22.4700
            14  C1x C    18.9502  -20.3700
            15  C1x C    17.7378  -21.0700
            16  C5x C    17.7378  -22.4700
            17  C2x C    18.9502  -23.1700
            18  C1a C    23.8000  -17.5700
            19  O1a O    25.0124  -16.8700
            20  C3b C    26.2248  -17.5700
            21  O5x O    16.5047  -23.1822
            22  C3a C    27.3860  -16.9510
BOND        25
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    9   2 1
            11    8  10 2
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13   9 1
            16   10  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   17  11 2
            21    1  18 1 #Up
            22    5  19 1 #Up
            23    5  20 1 #Down
            24   16  21 2
            25   20  22 3

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