Homo sapiens (human): 5241
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Entry
5241 CDS
T01001
Symbol
PGR, NR3C3, PR
Name
(RefSeq) progesterone receptor
KO
K08556
progesterone receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04114
Oocyte meiosis
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa05207
Chemical carcinogenesis - receptor activation
hsa05224
Breast cancer
Network
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06270
Breast cancer
nt06323
KISS1-GnRH-LH/FSH-E2 signaling
Element
N00286
Nuclear-initiated estrogen signaling pathway
N01358
P4-PR-PI3K signaling pathway
N01359
P4/MPA to PR-PI3K signaling pathway
N01360
P4-PR-RAS-ERK signaling pathway
N01361
P4/MPA to PR-RAS-ERK signaling pathway
N01362
Nuclear-initiated progesterone signaling pathway
N01363
P4/MPA to nuclear-initiated progesterone signaling pathway
Disease
H00031
Breast cancer
Drug target
Aglepristone:
D07096
Allylestrenol:
D01374
Altrenogest:
D02840
Amadinone acetate:
D02881
Asoprisnil:
D02996
Chlormadinone (
DG00469
):
D01299
<JP>
D07670
Danazol:
D00289
<JP/US>
Demegestone:
D07223
Desogestrel:
D02367
Dienogest:
D03799
<JP>
Drospirenone:
D03917
<US>
Dydrogesterone:
D01217
<JP>
Ethylestrenol:
D01414
Etonogestrel:
D04104
<US>
Etynodiol (
DG00470
):
D01294
D07939
Flugestone:
D07968
Gestaclone:
D04315
Gestodene:
D04316
Gestonorone:
D01159
<JP>
Hydroxyprogesterone (
DG00467
):
D00949
<JP/US>
D08052
D08053
Levonorgestrel:
D00950
<JP/US>
Lonaprisan:
D10016
Lynestrenol:
D01580
Medrogestone:
D04885
Medroxyprogesterone (
DG00458
):
D00951
<JP/US>
D08166
Megestrol (
DG00457
):
D00952
<US>
D08167
Methynodiol diacetate:
D05003
Metogest:
D05009
Mifepristone:
D00585
<US>
Nomegestrol (
DG00468
):
D07222
D08281
Norelgestromin:
D05205
Norethisterone (
DG00456
):
D00182
<JP/US>
D00953
<US>
D08285
Norethynodrel:
D05207
Norgestimate:
D05209
Norgestrel:
D00954
Norgestrienone:
D07220
Onapristone:
D09571
Oxogestone phenpropionate:
D05308
Progesterone:
D00066
<JP/US>
Proligestone:
D08429
Promegestone:
D08431
Quingestanol:
D05679
Quingestrone:
D05680
Segesterone (
DG02828
):
D10986
D10987
Tanaproget:
D06003
Telapristone acetate:
D09972
Tigestol:
D06145
Tosagestin:
D06197
Trimegestone:
D06235
Ulipristal (
DG00459
):
D09567
D09687
<US>
Vilaprisan:
D11181
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04915 Estrogen signaling pathway
5241 (PGR)
09160 Human Diseases
09161 Cancer: overview
05207 Chemical carcinogenesis - receptor activation
5241 (PGR)
09162 Cancer: specific types
05224 Breast cancer
5241 (PGR)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
5241 (PGR)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
5241 (PGR)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 estrogen receptor-like
5241 (PGR)
Nuclear receptors [BR:
hsa03310
]
3. Estrogen like
3C. 3-Ketosteroid receptor
5241 (PGR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Prog_receptor
Hormone_recep
zf-C4
Motif
Other DBs
NCBI-GeneID:
5241
NCBI-ProteinID:
NP_000917
OMIM:
607311
HGNC:
8910
Ensembl:
ENSG00000082175
UniProt:
P06401
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(101029624..101129813)
Genome browser
AA seq
933 aa
AA seq
DB search
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
NT seq
2802 nt
NT seq
+upstream
nt +downstream
nt
atgactgagctgaaggcaaagggtccccgggctccccacgtggcgggcggcccgccctcc
cccgaggtcggatccccactgctgtgtcgcccagccgcaggtccgttcccggggagccag
acctcggacaccttgcctgaagtttcggccatacctatctccctggacgggctactcttc
cctcggccctgccagggacaggacccctccgacgaaaagacgcaggaccagcagtcgctg
tcggacgtggagggcgcatattccagagctgaagctacaaggggtgctggaggcagcagt
tctagtcccccagaaaaggacagcggactgctggacagtgtcttggacactctgttggcg
ccctcaggtcccgggcagagccaacccagccctcccgcctgcgaggtcaccagctcttgg
tgcctgtttggccccgaacttcccgaagatccaccggctgcccccgccacccagcgggtg
ttgtccccgctcatgagccggtccgggtgcaaggttggagacagctccgggacggcagct
gcccataaagtgctgccccggggcctgtcaccagcccggcagctgctgctcccggcctct
gagagccctcactggtccggggccccagtgaagccgtctccgcaggccgctgcggtggag
gttgaggaggaggatggctctgagtccgaggagtctgcgggtccgcttctgaagggcaaa
cctcgggctctgggtggcgcggcggctggaggaggagccgcggctgtcccgccgggggcg
gcagcaggaggcgtcgccctggtccccaaggaagattcccgcttctcagcgcccagggtc
gccctggtggagcaggacgcgccgatggcgcccgggcgctccccgctggccaccacggtg
atggatttcatccacgtgcctatcctgcctctcaatcacgccttattggcagcccgcact
cggcagctgctggaagacgaaagttacgacggcggggccggggctgccagcgcctttgcc
ccgccgcggagttcaccctgtgcctcgtccaccccggtcgctgtaggcgacttccccgac
tgcgcgtacccgcccgacgccgagcccaaggacgacgcgtaccctctctatagcgacttc
cagccgcccgctctaaagataaaggaggaggaggaaggcgcggaggcctccgcgcgctcc
ccgcgttcctaccttgtggccggtgccaaccccgcagccttcccggatttcccgttgggg
ccaccgcccccgctgccgccgcgagcgaccccatccagacccggggaagcggcggtgacg
gccgcacccgccagtgcctcagtctcgtctgcgtcctcctcggggtcgaccctggagtgc
atcctgtacaaagcggagggcgcgccgccccagcagggcccgttcgcgccgccgccctgc
aaggcgccgggcgcgagcggctgcctgctcccgcgggacggcctgccctccacctccgcc
tctgccgccgccgccggggcggcccccgcgctctaccctgcactcggcctcaacgggctc
ccgcagctcggctaccaggccgccgtgctcaaggagggcctgccgcaggtctacccgccc
tatctcaactacctgaggccggattcagaagccagccagagcccacaatacagcttcgag
tcattacctcagaagatttgtttaatctgtggggatgaagcatcaggctgtcattatggt
gtccttacctgtgggagctgtaaggtcttctttaagagggcaatggaagggcagcacaac
tacttatgtgctggaagaaatgactgcatcgttgataaaatccgcagaaaaaactgccca
gcatgtcgccttagaaagtgctgtcaggctggcatggtccttggaggtcgaaaatttaaa
aagttcaataaagtcagagttgtgagagcactggatgctgttgctctcccacagccagtg
ggcgttccaaatgaaagccaagccctaagccagagattcactttttcaccaggtcaagac
atacagttgattccaccactgatcaacctgttaatgagcattgaaccagatgtgatctat
gcaggacatgacaacacaaaacctgacacctccagttctttgctgacaagtcttaatcaa
ctaggcgagaggcaacttctttcagtagtcaagtggtctaaatcattgccaggttttcga
aacttacatattgatgaccagataactctcattcagtattcttggatgagcttaatggtg
tttggtctaggatggagatcctacaaacacgtcagtgggcagatgctgtattttgcacct
gatctaatactaaatgaacagcggatgaaagaatcatcattctattcattatgccttacc
atgtggcagatcccacaggagtttgtcaagcttcaagttagccaagaagagttcctctgt
atgaaagtattgttacttcttaatacaattcctttggaagggctacgaagtcaaacccag
tttgaggagatgaggtcaagctacattagagagctcatcaaggcaattggtttgaggcaa
aaaggagttgtgtcgagctcacagcgtttctatcaacttacaaaacttcttgataacttg
catgatcttgtcaaacaacttcatctgtactgcttgaatacatttatccagtcccgggca
ctgagtgttgaatttccagaaatgatgtctgaagttattgctgcacaattacccaagata
ttggcagggatggtgaaaccccttctctttcataaaaagtga
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