KEGG   DRUG: Ambroxol
Entry
D07442                      Drug                                   
Name
Ambroxol (INN);
Tabcin (TN)
Formula
C13H18Br2N2O
Exact mass
375.9786
Mol weight
378.1028
Structure
Simcomp
Remark
ATC code: R02AD05 R05CB06
Chemical structure group: DG01073
Product (DG01073): D01479<JP>
Efficacy
Expectorant, Mucolytic
Comment
Bromhexine derivative
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD05 Ambroxol
      D07442  Ambroxol (INN)
  R05 COUGH AND COLD PREPARATIONS
   R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
    R05CB Mucolytics
     R05CB06 Ambroxol
      D07442  Ambroxol (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ambroxol
    D07442  Ambroxol (INN)
Other DBs
CAS: 18683-91-5
PubChem: 51091773
LigandBox: D07442
NIKKAJI: J13.659J
LinkDB
KCF data

ATOM        18
            1   C8y C    19.8800  -17.5700
            2   C8x C    19.8800  -18.9700
            3   C8y C    21.1400  -19.6700
            4   C8y C    22.3300  -18.9700
            5   C8y C    22.3300  -17.5700
            6   C8x C    21.1400  -16.8700
            7   X   Br   18.6900  -16.8700
            8   X   Br   21.1400  -21.0700
            9   N1a N    23.5200  -19.6700
            10  C1b C    23.5200  -16.8700
            11  N1b N    24.7800  -17.5700
            12  C1y C    25.9700  -16.8700
            13  C1x C    27.1600  -17.5700
            14  C1x C    28.3500  -16.8700
            15  C1y C    28.3500  -15.4700
            16  C1x C    27.1600  -14.7700
            17  C1x C    25.9700  -15.4700
            18  O1a O    29.6100  -14.7700
BOND        19
            1     4   9 1
            2     2   3 1
            3     5  10 1
            4     3   4 2
            5    10  11 1
            6     4   5 1
            7     5   6 2
            8     6   1 1
            9     1   7 1
            10    3   8 1
            11    1   2 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   12  17 1
            19   15  18 1 #Up

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KEGG   DRUG: Ambroxol hydrochloride
Entry
D01479                      Drug                                   
Name
Ambroxol hydrochloride (JAN);
Hustless (TN)
Formula
C13H18Br2N2O. HCl
Exact mass
411.9553
Mol weight
414.5638
Structure
Simcomp
Remark
Therapeutic category: 2239
ATC code: R02AD05 R05CB06
Chemical structure group: DG01073
Product (DG01073): D01479<JP>
Efficacy
Expectorant, Mucolytic
Comment
Bromhexine derivative
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD05 Ambroxol
      D01479  Ambroxol hydrochloride (JAN) <JP>
  R05 COUGH AND COLD PREPARATIONS
   R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
    R05CB Mucolytics
     R05CB06 Ambroxol
      D01479  Ambroxol hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   223  Expectorants
    2239  Others
     D01479  Ambroxol hydrochloride (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ambroxol
    D01479  Ambroxol hydrochloride (JAN)
Rx-to-OTC switch list in Japan [br08314.html]
 D01479
Other DBs
CAS: 23828-92-4
PubChem: 7848542
ChEBI: 31198
LigandBox: D01479
NIKKAJI: J369.152G
LinkDB
KCF data

ATOM        19
            1   C8y C    20.0844  -16.9289
            2   C8x C    20.0844  -18.3292
            3   C8y C    21.3000  -19.0293
            4   C8y C    22.5085  -18.3292
            5   C8y C    22.5085  -16.9289
            6   C8x C    21.3000  -16.2287
            7   X   Br   18.8720  -16.2281
            8   X   Br   21.3017  -20.4296
            9   N1a N    23.7216  -19.0285
            10  C1b C    23.7216  -16.2296
            11  N1b N    24.9338  -16.9308
            12  C1y C    26.1324  -16.2400
            13  C1x C    27.3274  -16.9314
            14  C1x C    28.5405  -16.2325
            15  C1y C    28.5417  -14.8325
            16  C1x C    27.3468  -14.1411
            17  C1x C    26.1337  -14.8400
            18  O1a O    29.7651  -14.1275
            19  X   Cl   32.0505  -17.4946
BOND        19
            1     4   9 1
            2     2   3 1
            3     5  10 1
            4     3   4 2
            5    10  11 1
            6     4   5 1
            7     5   6 2
            8     6   1 1
            9     1   7 1
            10    3   8 1
            11    1   2 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   12  17 1
            19   15  18 1 #Up

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