KEGG   DRUG: Azithromycin
Entry
D07486                      Drug                                   
Name
Azithromycin (INN);
Azasite (TN);
Azithromycin (TN)
Product
  Generic
Formula
C38H72N2O12
Exact mass
748.5085
Mol weight
748.9845
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01875  15-Membered ring macrolide antibiotic
Transporter substrate
 DG01665  ABCB1 substrate
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Same as: C06838
ATC code: J01FA10 S01AA26
Chemical structure group: DG00606
Product (DG00606): D07486<US> D02134<JP/US> D06390<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Urethritis and cervicitis due to Chlamydia trachomatis [DS:H00347]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D07486  Azithromycin (INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA26 Azithromycin
      D07486  Azithromycin (INN) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D07486  Azithromycin (INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Azithromycin
     D07486  Azithromycin (INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
     D07486  Azithromycin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
    D07486  Azithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
    D07486  Azithromycin
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D07486  Azithromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D07486  Azithromycin (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D07486
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00606  Azithromycin
Other DBs
CAS: 83905-01-5
PubChem: 51091811
ChEBI: 2955
PDB-CCD: ZIT[PDBj]
LigandBox: D07486
NIKKAJI: J134.080H
LinkDB
KCF data

ATOM        52
            1   C1y C    21.6300  -16.2400
            2   C1y C    20.3700  -16.8700
            3   O2a O    23.1700  -17.2200
            4   C1z C    21.6300  -14.9100
            5   C1y C    20.3700  -18.2000
            6   C1a C    19.6000  -15.8900
            7   C1y C    24.5000  -16.4500
            8   C1x C    20.8600  -14.3500
            9   C1a C    22.8200  -15.4700
            10  O1a O    22.8200  -14.2100
            11  O2a O    21.1400  -20.1600
            12  C1y C    19.2500  -18.8300
            13  C1y C    25.2700  -17.7100
            14  O2x O    25.2700  -15.1900
            15  C1y C    21.3500  -13.0900
            16  C1y C    22.7500  -20.8600
            17  C7x C    18.1300  -18.2000
            18  C1a C    19.1800  -20.1600
            19  C1y C    26.6700  -17.7100
            20  O1a O    24.5000  -18.9700
            21  C1y C    26.6700  -15.1900
            22  C1x C    20.5100  -12.2500
            23  C1a C    22.3300  -12.5300
            24  C1x C    22.7500  -22.3300
            25  O2x O    24.0100  -20.1600
            26  O7x O    18.1300  -16.8700
            27  O6a O    17.1500  -19.1800
            28  C1x C    27.3700  -16.4500
            29  N1c N    27.3700  -18.9700
            30  C1a C    27.3700  -14.0000
            31  N1y N    19.3200  -12.2500
            32  C1z C    24.0100  -23.0300
            33  C1y C    25.2000  -20.8600
            34  C1y C    17.0100  -16.1700
            35  C1a C    28.7700  -19.8800
            36  C1a C    28.7000  -18.2700
            37  C1y C    18.2000  -12.8800
            38  C1a C    19.3200  -10.8500
            39  C1y C    25.2000  -22.3300
            40  O2a O    23.9400  -24.3600
            41  C1a C    26.4600  -20.1600
            42  C1z C    17.0100  -14.8400
            43  C1b C    15.8200  -16.8000
            44  C1y C    18.2000  -14.2100
            45  C1a C    17.0100  -12.1800
            46  O1a O    26.4600  -23.0300
            47  C1a C    25.1300  -25.0600
            48  C1a C    15.6800  -15.3300
            49  O1a O    15.8200  -13.7200
            50  C1a C    15.8200  -18.1300
            51  O1a O    19.3200  -14.9100
            52  C1a C    22.7500  -23.7300
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up

» Japanese version   » Back

KEGG   DRUG: Azithromycin hydrate
Entry
D02134                      Drug                                   
Name
Azithromycin hydrate (JP18);
Azithromycin dihydrate;
Zithromac (TN);
Zmax (TN);
Azimycin (TN)
Product
  Generic
AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (Alembic Pharmaceuticals Limited), AZITHROMYCIN (Alembic Pharmaceuticals Limited), AZITHROMYCIN (Alembic Pharmaceuticals Limited), AZITHROMYCIN (Alembic Pharmaceuticals), AZITHROMYCIN (Alembic Pharmaceuticals), AZITHROMYCIN (Alembic Pharmaceuticals), AZITHROMYCIN (Asclemed USA), AZITHROMYCIN (Asclemed USA), AZITHROMYCIN (Aurobindo Pharma Limited), AZITHROMYCIN (Aurobindo Pharma Limited), AZITHROMYCIN (AvKARE), AZITHROMYCIN (AvKARE), AZITHROMYCIN (Bionpharma), AZITHROMYCIN (Bionpharma), AZITHROMYCIN (DIRECT RX), AZITHROMYCIN (Direct_Rx), AZITHROMYCIN (Doc Rx), AZITHROMYCIN (Greenstone LLC), AZITHROMYCIN (Greenstone LLC), AZITHROMYCIN (Hainan Poly Pharm.), AZITHROMYCIN (Medsource Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (RPK Pharmaceuticals), AZITHROMYCIN (RPK Pharmaceuticals), AZITHROMYCIN (RPK Pharmaceuticals), AZITHROMYCIN (RedPharm Drug), AZITHROMYCIN (RedPharm Drug), AZITHROMYCIN (Sandoz), AZITHROMYCIN (Slate Run Pharmaceuticals), AZITHROMYCIN (St. Mary's Medical Park Pharmacy), AZITHROMYCIN (Zydus Lifesciences Limited), AZITHROMYCIN (Zydus Pharmaceuticals USA), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (ACI Healthcare USA), AZITHROMYCIN DIHYDRATE (ACI Healthcare USA), AZITHROMYCIN DIHYDRATE (Advanced Rx Pharmacy of Tennessee), AZITHROMYCIN DIHYDRATE (Advanced Rx Pharmacy of Tennessee), AZITHROMYCIN DIHYDRATE (American Health Packaging), AZITHROMYCIN DIHYDRATE (Asclemed USA), AZITHROMYCIN DIHYDRATE (AvPAK), AZITHROMYCIN DIHYDRATE (DIRECT RX), AZITHROMYCIN DIHYDRATE (Lupin Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Lupin Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Major Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Medsource Pharmaceuticals), AZITHROMYCIN DIHYDRATE (NuCare Pharmaceuticals), AZITHROMYCIN DIHYDRATE (NuCare Pharmceuticals), AZITHROMYCIN DIHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN DIHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN DIHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN DIHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN DIHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Precision Dose), AZITHROMYCIN DIHYDRATE (Precision Dose), AZITHROMYCIN DIHYDRATE (Precision Dose), AZITHROMYCIN DIHYDRATE (Preferred Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Preferred Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Proficient Rx LP), AZITHROMYCIN DIHYDRATE (Proficient Rx LP), AZITHROMYCIN DIHYDRATE (Quality Care Products), AZITHROMYCIN DIHYDRATE (REMEDYREPACK), AZITHROMYCIN DIHYDRATE (REMEDYREPACK), AZITHROMYCIN DIHYDRATE (REMEDYREPACK), AZITHROMYCIN DIHYDRATE (REMEDYREPACK), AZITHROMYCIN DIHYDRATE (RPK Pharmaceuticals), AZITHROMYCIN DIHYDRATE (RPK Pharmaceuticals), AZITHROMYCIN DIHYDRATE (RPK Pharmaceuticals), AZITHROMYCIN DIHYDRATE (RPK Pharmaceuticals), AZITHROMYCIN DIHYDRATE (RedPharm Drug), AZITHROMYCIN DIHYDRATE (Slate Run Pharmaceuticals), AZITHROMYCIN DIHYDRATE (TAGI Pharma), AZITHROMYCIN DIHYDRATE (TAGI Pharma), AZITHROMYCIN DIHYDRATE (TAGI Pharma)
Formula
C38H72N2O12. 2H2O
Exact mass
784.5297
Mol weight
785.015
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01875  15-Membered ring macrolide antibiotic
Transporter substrate
 DG01665  ABCB1 substrate
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Therapeutic category: 1317 6149
ATC code: J01FA10 S01AA26
Chemical structure group: DG00606
Product (DG00606): D07486<US> D02134<JP/US> D06390<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Urethritis due to Chlamydia trachomatis [DS:H00347]
Disseminated Mycobacterium avium complex (MAC) disease [DS:H01458]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D02134  Azithromycin hydrate (JP18) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA26 Azithromycin
      D02134  Azithromycin hydrate (JP18) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D02134  Azithromycin hydrate (JP18)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Azithromycin
     D02134  Azithromycin hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D02134  Azithromycin hydrate (JP18)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6149  Others
     D02134  Azithromycin hydrate (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
     D02134  Azithromycin hydrate
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
    D02134  Azithromycin hydrate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
    D02134  Azithromycin hydrate
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D02134  Azithromycin hydrate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02134  Azithromycin hydrate (JP18) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02134  Azithromycin hydrate
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02134
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D02134
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00606  Azithromycin
Other DBs
CAS: 117772-70-0
PubChem: 7849195
ChEBI: 34546
LigandBox: D02134
NIKKAJI: J1.893.284I
LinkDB
KCF data

ATOM        54
            1   C1y C    24.7580  -16.6914
            2   C1y C    23.5463  -17.3176
            3   O2a O    26.3209  -17.6570
            4   C1z C    24.8046  -15.3624
            5   C1y C    23.5462  -18.6405
            6   C1a C    22.7374  -16.2886
            7   C1y C    27.6732  -16.8903
            8   C1x C    24.0087  -14.7889
            9   C1a C    25.9698  -15.9186
            10  O1a O    25.9815  -14.6425
            11  O2a O    24.2837  -20.5664
            12  C1y C    22.3930  -19.2846
            13  C1y C    28.3990  -18.1312
            14  O2x O    28.3873  -15.6375
            15  C1y C    24.4887  -13.5242
            16  C1y C    25.8876  -21.2806
            17  C7x C    21.2690  -18.5879
            18  C1a C    22.3637  -20.6075
            19  C1y C    29.8333  -18.1195
            20  O1a O    27.6849  -19.3841
            21  C1y C    29.8273  -15.6375
            22  C1x C    23.6926  -12.7049
            23  C1a C    25.5074  -12.9684
            24  C1x C    25.8876  -22.7265
            25  O2x O    27.1289  -20.5664
            26  O7x O    21.2925  -17.2650
            27  O6a O    20.3146  -19.5655
            28  C1x C    30.5415  -16.8786
            29  N1c N    30.5532  -19.3664
            30  C1a C    30.5415  -14.3907
            31  N1y N    22.4751  -12.6639
            32  C1z C    27.1289  -23.4407
            33  C1y C    28.3755  -21.2806
            34  C1y C    20.1627  -16.5917
            35  C1a C    31.9173  -20.2738
            36  C1a C    31.8469  -18.6699
            37  C1y C    21.3219  -13.2902
            38  C1a C    22.5041  -11.2941
            39  C1y C    28.3755  -22.7265
            40  O2a O    27.1172  -24.7754
            41  C1a C    29.6166  -20.5664
            42  C1z C    20.1511  -15.2630
            43  C1b C    19.0038  -17.2124
            44  C1y C    21.3160  -14.6308
            45  C1a C    20.1628  -12.6112
            46  O1a O    29.6166  -23.4407
            47  C1a C    28.2703  -25.4544
            48  C1a C    18.8634  -15.7723
            49  O1a O    19.0038  -14.1742
            50  C1a C    18.9744  -18.5410
            51  O1a O    22.4633  -15.3039
            52  C1a C    25.9163  -24.1408
            53  O0  O    35.0000  -23.3800
            54  O0  O    35.0000  -23.3800
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up
BRACKET     1    33.1100  -24.4300   33.1100  -22.4700
            1    35.4200  -22.4700   35.4200  -24.4300
            1  2
 ORIGINAL  1   53
 REPEAT    1   54

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KEGG   DRUG: Azithromycin
Entry
D06390                      Drug                                   
Name
Azithromycin (USP);
Zmax (TN)
Product
  Generic
AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (Advanced Rx Pharmacy of Tennessee), AZITHROMYCIN (Aphena Pharma Solutions - Tennessee), AZITHROMYCIN (Asclemed USA), AZITHROMYCIN (Athenex Pharmaceutical Division), AZITHROMYCIN (Athenex Pharmaceutical Division), AZITHROMYCIN (Chartwell RX), AZITHROMYCIN (DirectRx), AZITHROMYCIN (Epic Pharma), AZITHROMYCIN (Eugia US LLC), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Hospira), AZITHROMYCIN (Hospira), AZITHROMYCIN (Lannett Company), AZITHROMYCIN (Medsource Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS), AZITHROMYCIN (PharmPak), AZITHROMYCIN (Pharmasource Meds), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Quality Care Products LLC), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (RPK Pharmaceuticals), AZITHROMYCIN (RPK Pharmaceuticals), AZITHROMYCIN (STATE HEALTH SERVICES), AZITHROMYCIN (Sandoz), AZITHROMYCIN (St. Mary's Medical Park Pharmacy), AZITHROMYCIN (Sun Pharmaceutical Industries), AZITHROMYCIN (Taro Pharmaceuticals U.S.A.), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN MONOHYDRATE (American Health Packaging), AZITHROMYCIN MONOHYDRATE (American Health Packaging), AZITHROMYCIN MONOHYDRATE (Amneal Pharmaceuticals LLC), AZITHROMYCIN MONOHYDRATE (Cardinal Health 107), AZITHROMYCIN MONOHYDRATE (Gland Pharma Limited), AZITHROMYCIN MONOHYDRATE (Lupin Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (Lupin Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (Major Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (PD-Rx Pharmaceuticals), AZITHROMYCIN MONOHYDRATE (Proficient Rx LP), AZITHROMYCIN MONOHYDRATE (Proficient Rx LP), AZITHROMYCIN MONOHYDRATE (REMEDYREPACK), AZITHROMYCIN MONOHYDRATE (Sun Pharmaceutical Industries Limited)
Formula
C38H72N2O12. xH2O
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01875  15-Membered ring macrolide antibiotic
Transporter substrate
 DG01665  ABCB1 substrate
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: J01FA10 S01AA26
Chemical structure group: DG00606
Product (DG00606): D07486<US> D02134<JP/US> D06390<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Bacterial conjunctivitis [DS:H01360]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D06390  Azithromycin (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA26 Azithromycin
      D06390  Azithromycin (USP) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D06390  Azithromycin (USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Azithromycin
     D06390  Azithromycin (USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
     D06390  Azithromycin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
    D06390  Azithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
    D06390  Azithromycin
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D06390  Azithromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D06390  Azithromycin (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D06390
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01875  15-Membered ring macrolide antibiotic
    DG00606  Azithromycin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00606  Azithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00606  Azithromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00606  Azithromycin
Other DBs
PubChem: 47208047
LigandBox: D06390
LinkDB
KCF data

ATOM        53
            1   C1y C    22.6580  -16.6914
            2   C1y C    21.4463  -17.3176
            3   O2a O    24.2209  -17.6570
            4   C1z C    22.7046  -15.3624
            5   C1y C    21.4462  -18.6405
            6   C1a C    20.6374  -16.2886
            7   C1y C    25.5732  -16.8903
            8   C1x C    21.9087  -14.7889
            9   C1a C    23.8698  -15.9186
            10  O1a O    23.8815  -14.6425
            11  O2a O    22.1837  -20.5664
            12  C1y C    20.2930  -19.2846
            13  C1y C    26.2990  -18.1312
            14  O2x O    26.2873  -15.6375
            15  C1y C    22.3887  -13.5242
            16  C1y C    23.7876  -21.2806
            17  C7x C    19.1690  -18.5879
            18  C1a C    20.2637  -20.6075
            19  C1y C    27.7334  -18.1195
            20  O1a O    25.5849  -19.3841
            21  C1y C    27.7274  -15.6375
            22  C1x C    21.5926  -12.7049
            23  C1a C    23.4074  -12.9684
            24  C1x C    23.7876  -22.7265
            25  O2x O    25.0289  -20.5664
            26  O7x O    19.1925  -17.2650
            27  O6a O    18.2146  -19.5655
            28  C1x C    28.4416  -16.8786
            29  N1c N    28.4533  -19.3664
            30  C1a C    28.4416  -14.3907
            31  N1y N    20.3751  -12.6639
            32  C1z C    25.0289  -23.4407
            33  C1y C    26.2755  -21.2806
            34  C1y C    18.0627  -16.5917
            35  C1a C    29.8174  -20.2738
            36  C1a C    29.7470  -18.6699
            37  C1y C    19.2219  -13.2902
            38  C1a C    20.4041  -11.2941
            39  C1y C    26.2755  -22.7265
            40  O2a O    25.0172  -24.7754
            41  C1a C    27.5166  -20.5664
            42  C1z C    18.0511  -15.2630
            43  C1b C    16.9038  -17.2124
            44  C1y C    19.2160  -14.6308
            45  C1a C    18.0628  -12.6112
            46  O1a O    27.5166  -23.4407
            47  C1a C    26.1703  -25.4544
            48  C1a C    16.7634  -15.7723
            49  O1a O    16.9038  -14.1742
            50  C1a C    16.8744  -18.5410
            51  O1a O    20.3633  -15.3039
            52  C1a C    23.8163  -24.1408
            53  O0  O    32.1300  -23.5900
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up
BRACKET     1    30.1000  -24.6400   30.1000  -22.4000
            1    32.7600  -22.4000   32.7600  -24.6400
            1  x
 ORIGINAL  1   53
 REPEAT    1

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