KEGG   DRUG: Isopropylantipyrine, ergotamine tartrate and anhydrous caffeine
Entry
D07585            Mixture   Drug                                   

Name
Isopropylantipyrine, ergotamine tartrate and anhydrous caffeine;
Cleamine A (TN)
Component
Isopropylantipyrine [DR:D01380], Ergotamine tartrate [DR:D00679], Anhydrous caffeine [DR:D00528]
Class
Neuropsychiatric agent
 DG01982  Antimigraine, ergot alkaloid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1149
ATC code: N02CA52
Product: D07585<JP>
Efficacy
Antimigraine
Comment
Ergotamine is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CA Ergot alkaloids
     N02CA52 Ergotamine, combinations excl. psycholeptics
      D07585  Isopropylantipyrine, ergotamine tartrate and anhydrous caffeine <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D07585  Isopropylantipyrine, ergotamine tartrate and anhydrous caffeine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07585
Other DBs
PubChem: 96024447
LinkDB

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