KEGG   DRUG: CevimelineHelp
Entry
D07667                      Drug                                   

Name
Cevimeline (INN)
Formula
C10H17NOS
Exact mass
199.1031
Mol weight
199.3131
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
ATC code: N07AX03
Chemical structure group: DG00993
Product (DG00993): D00661<JP/US>
Efficacy
Salivation accelaletor, Muscarinic acetylcholine receptor agonist
Comment
Arecoline derivative
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D07667  Cevimeline (INN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D07667  Cevimeline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D07667  Cevimeline (INN)
BRITE hierarchy
Other DBs
CAS: 107233-08-9
PubChem: 51091969
ChEBI: 3568
ChEMBL: CHEMBL167593
DrugBank: DB00185
LigandBox: D07667
NIKKAJI: J1.049.900C
LinkDB All DBs
KCF data Show

ATOM        13
            1   C1z C    24.2900  -17.4300
            2   C1y C    24.2900  -16.0300
            3   C1x C    23.0300  -18.2000
            4   C1x C    23.0300  -15.2600
            5   C1x C    23.4500  -16.8700
            6   N1y N    21.7700  -17.4300
            7   C1x C    21.7700  -16.0300
            8   C1x C    22.7500  -16.3800
            9   O2x O    24.2900  -18.8300
            10  C1y C    25.6900  -19.3200
            11  S2x S    26.5300  -18.1300
            12  C1x C    25.6900  -16.9400
            13  C1a C    26.1100  -20.6500
BOND        15
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down

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