KEGG   DRUG: DiclofenacHelp
Entry
D07816                      Drug                                   

Name
Diclofenac (USAN/INN);
Solaraze (TN);
Zorvolex (TN)
Product
Formula
C14H11Cl2NO2
Exact mass
295.0167
Mol weight
296.1486
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01906  Antiinflammatory drug, acetic acid derivatives
  DG01898  Antiinflammatory drug, phenylacetic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01906  Antiinflammatory drug, acetic acid derivatives
   DG01898  Antiinflammatory drug, phenylacetic acid derivatives
Enzyme substrate
 DG01642  CYP2C9 substrate
Transporter inhibitor
 DG02866  SLC22A8 (OAT3) inhibitor
Remark
Same as: C01690
ATC code: D11AX18 M01AB05 M02AA15 S01BC03
Chemical structure group: DG00441
Product (DG00441): D07816<US> D00903<US> D00904<JP/US> D07818<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Transporter inhibition: SLC22A8 [HSA:9376]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX18 Diclofenac
      D07816  Diclofenac (USAN/INN) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB05 Diclofenac
      D07816  Diclofenac (USAN/INN) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA15 Diclofenac
      D07816  Diclofenac (USAN/INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC03 Diclofenac
      D07816  Diclofenac (USAN/INN) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D07816  Diclofenac (USAN/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D07816  Diclofenac (USAN/INN)
 Dermatological Agents
  Diclofenac
   D07816  Diclofenac (USAN/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Diclofenac
    D07816  Diclofenac (USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Diclofenac
    D07816  Diclofenac (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D07816  Diclofenac (USAN/INN) <US>
    PTGS2 (COX2)
     D07816  Diclofenac (USAN/INN) <US>
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D07816
 Anesthetics, analgesics and anti-inflammatory drugs
  D07816
BRITE hierarchy
Other DBs
CAS: 15307-86-5
PubChem: 96024513
ChEBI: 47381
ChEMBL: CHEMBL139
DrugBank: DB00586
PDB-CCD: DIF[PDBj]
LigandBox: D07816
NIKKAJI: J8.557J
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    22.4000  -19.3200
            2   C8x C    22.4000  -20.7200
            3   C8x C    23.5900  -21.4200
            4   C8x C    24.7800  -20.7200
            5   C8y C    24.7800  -19.3200
            6   C8y C    23.5900  -18.6200
            7   C1b C    26.0400  -18.6200
            8   C6a C    27.2300  -19.2500
            9   O6a O    28.4200  -18.6200
            10  O6a O    27.2300  -20.7200
            11  N1b N    23.5900  -17.2200
            12  C8y C    22.3300  -16.5200
            13  C8y C    22.3300  -15.1200
            14  C8x C    21.1400  -14.4200
            15  C8x C    19.9500  -15.1200
            16  C8x C    19.9500  -16.5200
            17  C8y C    21.1400  -17.2200
            18  X   Cl   23.5900  -14.4200
            19  X   Cl   21.1400  -18.6200
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    6  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   13  18 1
            20   17  19 1

» Japanese version   » Back

DBGET integrated database retrieval system