| Entry |
|
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| Name |
Diclofenac calcium;
Voltaren Actingo Extra (TN) |
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| Formula |
C28H20CaCl4N2O4
|
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| Exact mass |
627.9803
|
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| Mol weight |
630.35
|
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| Structure |
|
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Transporter inhibitor
DG02866 SLC22A8 inhibitor
|
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| Remark |
| Product (DG00441): | D00903<US> D00904<JP/US> D07818<US> |
|
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
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| Interaction |
Transporter inhibition: SLC22A8 [HSA: 9376]
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX18 Diclofenac
D07819 Diclofenac calcium
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB05 Diclofenac
D07819 Diclofenac calcium
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA15 Diclofenac
D07819 Diclofenac calcium
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC03 Diclofenac
D07819 Diclofenac calcium
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
D07819 Diclofenac calcium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
D07819 Diclofenac calcium
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
D07819 Diclofenac calcium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D07819 Diclofenac calcium
PTGS2 (COX2)
D07819 Diclofenac calcium
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07819
Drug transporters
D07819
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 39
1 C8x C 21.8400 -30.2400
2 C8x C 21.8400 -31.5700
3 C8x C 23.0300 -32.2700
4 C8x C 24.2900 -31.5700
5 C8y C 24.2900 -30.2400
6 C8y C 23.0300 -29.5400
7 C1b C 25.4800 -29.5400
8 C7a C 26.6700 -30.1700
9 O7a O 27.8600 -29.5400
10 O6a O 26.6700 -31.5700
11 N1b N 23.0300 -28.0700
12 C8y C 21.7700 -27.3700
13 C8y C 21.7700 -25.9700
14 C8x C 20.5800 -25.2700
15 C8x C 19.3900 -25.9700
16 C8x C 19.3900 -27.3700
17 C8y C 20.5800 -28.0700
18 X Cl 23.0300 -25.2700
19 X Cl 20.5800 -29.5400
20 Z Ca 29.1900 -30.6600
21 O7a O 30.5200 -29.5400
22 C8y C 34.1600 -30.2400
23 C8x C 34.1600 -31.6400
24 C8x C 35.3500 -32.3400
25 C8x C 36.6100 -31.6400
26 C8x C 36.6100 -30.2400
27 C8y C 35.3500 -29.5400
28 C1b C 32.9700 -29.5400
29 C7a C 31.7100 -30.2400
30 N1b N 35.3500 -28.1400
31 C8y C 36.6100 -27.4400
32 C8y C 37.8000 -28.1400
33 C8x C 39.1300 -27.5100
34 C8x C 39.0600 -26.1100
35 C8x C 37.8000 -25.3400
36 C8y C 36.6100 -26.0400
37 X Cl 35.4200 -25.3400
38 X Cl 37.8000 -29.5400
39 O6a O 31.7100 -31.6400
BOND 42
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 8 10 2
11 6 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 12 17 1
19 13 18 1
20 17 19 1
21 9 20 1
22 20 21 1
23 22 23 2
24 23 24 1
25 24 25 2
26 25 26 1
27 26 27 2
28 22 27 1
29 22 28 1
30 28 29 1
31 29 21 1
32 27 30 1
33 30 31 1
34 31 32 2
35 32 33 1
36 33 34 2
37 34 35 1
38 35 36 2
39 31 36 1
40 36 37 1
41 32 38 1
42 29 39 2
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