KEGG   DRUG: EflornithineHelp
Entry
D07883                      Drug                                   

Name
Eflornithine (INN)
Formula
C6H12F2N2O2
Exact mass
182.0867
Mol weight
182.1685
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Same as: C07997
ATC code: D11AX16 P01CX03
Chemical structure group: DG00440
Product (DG00440): D00829<US>
Efficacy
Antineoplastic, Antiprotozoal, Ornithine decarboxylase inhibitor
Target
ODC1 [HSA:4953] [KO:K01581]
  Pathway
hsa00330  Arginine and proline metabolism
hsa00480  Glutathione metabolism
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX16 Eflornithine
      D07883  Eflornithine (INN)
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01C AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
    P01CX Other agents against leishmaniasis and trypanosomiasis
     P01CX03 Eflornithine
      D07883  Eflornithine (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Carboxy-lyases
    ODC1
     D07883  Eflornithine (INN)
BRITE hierarchy
Other DBs
CAS: 67037-37-0
PubChem: 96024579
ChEBI: 41948
ChEMBL: CHEMBL830
LigandBox: D07883
NIKKAJI: J290.818B
LinkDB All DBs
KCF data Show

ATOM        12
            1   C1d C    22.8900  -17.9200
            2   C1b C    24.1500  -18.6200
            3   C6a C    22.8900  -16.5200
            4   C1c C    21.7000  -18.6200
            5   N1a N    22.8900  -19.3200
            6   C1b C    25.3400  -17.9200
            7   O6a O    24.1500  -15.8200
            8   O6a O    21.7000  -15.8200
            9   X   F    20.5100  -17.9200
            10  X   F    21.7000  -20.0200
            11  C1b C    26.5300  -18.6200
            12  N1a N    27.7900  -17.9200
BOND        11
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1
            10    6  11 1
            11   11  12 1

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