KEGG T01001: 4953

Homo sapiens (human): 4953

Entry

4953              CDS       T01001

Symbol

ODC1, BABS, NEDBA, NEDBIA, ODC

Name

(RefSeq) ornithine decarboxylase 1

K01581

ornithine decarboxylase [EC:4.1.1.17]

Organism

hsa Homo sapiens (human)

Pathway

hsa00330

Arginine and proline metabolism

hsa00480

Glutathione metabolism

hsa01100

Metabolic pathways

hsa04148

Efferocytosis

Module

hsa_M00134

Polyamine biosynthesis, arginine => ornithine => putrescine

Network

nt06033 Glycine, serine and arginine metabolism
nt06535 Efferocytosis

Element

N01623

Spermine biosynthesis

N01779

Continual efferocytosis enhanced by the AC-derived arginine and ornithine

Disease

H02919

Bachmann-Bupp syndrome

Drug target

Eflornithine (DG00440):

D00829<US> D07883

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    4953 (ODC1)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    4953 (ODC1)
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    4953 (ODC1)
Enzymes [BR:hsa01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.17  ornithine decarboxylase
     4953 (ODC1)

SSDB

Motif

Pfam:

Orn_Arg_deC_N Orn_DAP_Arg_deC AP_endonuc_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

2:complement(10439968..10448327)

AA seq 461 aa
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL
LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF
QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

NT seq 1386 nt +upstreamnt +downstreamnt
atgaacaactttggtaatgaagagtttgactgccacttcctcgatgaaggttttactgcc
aaggacattctggaccagaaaattaatgaagtttcttcttctgatgataaggatgccttc
tatgtggcagacctgggagacattctaaagaaacatctgaggtggttaaaagctctccct
cgtgtcacccccttttatgcagtcaaatgtaatgatagcaaagccatcgtgaagaccctt
gctgctaccgggacaggatttgactgtgctagcaagactgaaatacagttggtgcagagt
ctgggggtgcctccagagaggattatctatgcaaatccttgtaaacaagtatctcaaatt
aagtatgctgctaataatggagtccagatgatgacttttgatagtgaagttgagttgatg
aaagttgccagagcacatcccaaagcaaagttggttttgcggattgccactgatgattcc
aaagcagtctgtcgtctcagtgtgaaattcggtgccacgctcagaaccagcaggctcctt
ttggaacgggcgaaagagctaaatatcgatgttgttggtgtcagcttccatgtaggaagc
ggctgtaccgatcctgagaccttcgtgcaggcaatctctgatgcccgctgtgtttttgac
atgggggctgaggttggtttcagcatgtatctgcttgatattggcggtggctttcctgga
tctgaggatgtgaaacttaaatttgaagagatcaccggcgtaatcaacccagcgttggac
aaatactttccgtcagactctggagtgagaatcatagctgagcccggcagatactatgtt
gcatcagctttcacgcttgcagttaatatcattgccaagaaaattgtattaaaggaacag
acgggctctgatgacgaagatgagtcgagtgagcagacctttatgtattatgtgaatgat
ggcgtctatggatcatttaattgcatactctatgaccacgcacatgtaaagccccttctg
caaaagagacctaaaccagatgagaagtattattcatccagcatatggggaccaacatgt
gatggcctcgatcggattgttgagcgctgtgacctgcctgaaatgcatgtgggtgattgg
atgctctttgaaaacatgggcgcttacactgttgctgctgcctctacgttcaatggcttc
cagaggccgacgatctactatgtgatgtcagggcctgcgtggcaactcatgcagcaattc
cagaaccccgacttcccacccgaagtagaggaacaggatgccagcaccctgcctgtgtct
tgtgcctgggagagtgggatgaaacgccacagagcagcctgtgcttcggctagtattaat
gtgtag

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