KEGG   DRUG: Fluorouracil sodium salt
Entry
D07974                      Drug                                   

Name
Fluorouracil sodium salt;
Fluorouracil (TN)
Formula
C4H3FN2O2. xNa
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Metabolizing enzyme substrate
 DG02984  DPYD substrate
Remark
ATC code: L01BC02
Chemical structure group: DG00687
Product (DG00687): D00584<JP/US>
Efficacy
Antineoplastic, Antimetabolite
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Metabolism
Enzyme: DPYD [HSA:1806]
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC02 Fluorouracil
      D07974  Fluorouracil sodium salt
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     DG00687  Fluorouracil
      D07974  Fluorouracil sodium salt
 Metabolizing enzyme substrate
  DG02984  DPYD substrate
   DG00687  Fluorouracil
    D07974  Fluorouracil sodium salt
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D07974  Fluorouracil sodium salt
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07974
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     DG00687  Fluorouracil
 Metabolizing enzyme substrate
  DG02984  DPYD substrate
   DG00687  Fluorouracil
Other DBs
PubChem: 96024669
LigandBox: D07974
LinkDB
KCF data

ATOM        10
            1   C8y C    26.3200  -15.4700
            2   C8y C    25.1300  -16.2400
            3   N4x N    27.5100  -16.2400
            4   O5x O    26.3200  -14.0700
            5   C8x C    25.1300  -17.5700
            6   X   F    23.8700  -15.4700
            7   C8y C    27.5100  -17.5700
            8   N4x N    26.3200  -18.2700
            9   O5x O    28.7700  -18.2700
            10  Z   Na   32.2000  -17.2200
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 2
            9     7   8 1
BRACKET     1    30.9400  -18.0600   30.9400  -16.1000
            1    34.0900  -16.1000   34.0900  -18.0600
            1  x
 ORIGINAL  1   10
 REPEAT    1

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