KEGG   DRUG: FluvastatinHelp
Entry
D07983                      Drug                                   

Name
Fluvastatin (INN);
Fluvas (TN)
Formula
C24H26FNO4
Exact mass
411.1846
Mol weight
411.4659
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Same as: C07014
ATC code: C10AA04
Chemical structure group: DG00354
Product (DG00354): D00892<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Drug interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D07983  Fluvastatin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Fluvastatin
    D07983  Fluvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D07983  Fluvastatin (INN)
BRITE hierarchy
Other DBs
CAS: 93957-54-1
PubChem: 96024677
ChEBI: 38561 5136
ChEMBL: CHEMBL350239
DrugBank: DB01095
LigandBox: D07983
NIKKAJI: J360.319I
LinkDB All DBs
KCF data Show

ATOM        30
            1   C8y C    20.9855  -16.8573
            2   C8x C    20.9855  -18.2563
            3   C8x C    22.1746  -18.9557
            4   C8y C    23.4336  -18.2563
            5   C8x C    23.4336  -16.8573
            6   C8x C    22.1746  -16.1579
            7   X   F    19.7964  -16.1579
            8   C8y C    24.6227  -18.9557
            9   C8y C    25.1123  -20.2847
            10  C8y C    26.4413  -20.2847
            11  N4y N    26.8610  -18.9557
            12  C8y C    25.7418  -18.1164
            13  C8x C    24.4129  -21.5437
            14  C8x C    25.1123  -22.8028
            15  C8x C    26.5113  -22.8028
            16  C8x C    27.2107  -21.5437
            17  C2b C    25.7418  -16.7174
            18  C1a C    29.3091  -18.9557
            19  C1c C    28.1200  -18.2563
            20  C1a C    28.1200  -16.8573
            21  C2b C    26.9309  -16.0180
            22  C1c C    26.9309  -14.6191
            23  C1b C    28.1200  -13.9196
            24  C1c C    29.3091  -14.6191
            25  C1b C    30.4982  -13.9196
            26  C6a C    31.6873  -14.6191
            27  O6a O    32.8764  -13.9196
            28  O6a O    31.6873  -16.0180
            29  O1a O    25.7418  -13.9196
            30  O1a O    29.3091  -16.0180
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 2
            14    9  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   10  16 2
            19   12  17 1
            20   18  19 1
            21   11  19 1
            22   19  20 1
            23   17  21 2
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   22  29 1 #Down
            32   24  30 1 #Up

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