KEGG   DRUG: MedroxyprogesteroneHelp
Entry
D08166                      Drug                                   

Name
Medroxyprogesterone (INN);
Farlutal inyectable (TN)
Formula
C22H32O3
Exact mass
344.2351
Mol weight
344.4877
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
Same as: C07119
ATC code: G03AC06 G03DA02 L02AB02
Chemical structure group: DG00458
Product (DG00458): D00951<JP/US>
Efficacy
Antineoplastic, Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC06 Medroxyprogesterone
      D08166  Medroxyprogesterone (INN)
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA02 Medroxyprogesterone
      D08166  Medroxyprogesterone (INN)
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB02 Medroxyprogesterone
      D08166  Medroxyprogesterone (INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Medroxyprogesterone
    D08166  Medroxyprogesterone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D08166  Medroxyprogesterone (INN)
BRITE hierarchy
Other DBs
CAS: 520-85-4
PubChem: 96024856
ChEBI: 6715
ChEMBL: CHEMBL1390
DrugBank: DB00603
LigandBox: D08166
NIKKAJI: J6.606K
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1z C    27.6500  -15.9600
            2   C1z C    26.5300  -16.5900
            3   C1x C    28.8400  -16.6600
            4   O1a O    28.8400  -15.2600
            5   C5a C    27.7200  -14.5600
            6   C1y C    26.5300  -17.9900
            7   C1x C    25.3400  -15.9600
            8   C1a C    26.5300  -15.2600
            9   C1x C    28.8400  -17.9900
            10  C1a C    26.4600  -13.8600
            11  O5a O    28.9100  -13.8600
            12  C1y C    25.3400  -18.6900
            13  C1x C    24.1500  -16.5900
            14  C1y C    24.1500  -17.9900
            15  C1x C    25.3400  -20.0200
            16  C1z C    22.9600  -18.6200
            17  C1y C    24.1500  -20.7200
            18  C2y C    22.9600  -20.0200
            19  C1x C    21.7700  -17.9200
            20  C1a C    22.9600  -17.2900
            21  C1a C    24.1500  -22.0500
            22  C2x C    21.7700  -20.7200
            23  C1x C    20.5800  -18.6200
            24  C5x C    20.5800  -20.0200
            25  O5x O    19.3900  -20.7200
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13   12  14 1
            14   12  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1
            19   16  20 1 #Up
            20   17  21 1 #Down
            21   18  22 2
            22   19  23 1
            23   22  24 1
            24   24  25 2
            25    6   9 1
            26   13  14 1
            27   17  18 1
            28   23  24 1

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