KEGG   DRUG: PhenforminHelp
Entry
D08351                      Drug                                   

Name
Phenformin (BAN)
Formula
C10H15N5
Exact mass
205.1327
Mol weight
205.2596
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07673
ATC code: A10BA01
Chemical structure group: DG00112
Efficacy
Antidiabetic, Hypoglycemic
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Other map
map04152  AMPK signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA01 Phenformin
      D08351  Phenformin (BAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMKL family
    AMPK (PRKAA)
     D08351  Phenformin (BAN)
BRITE hierarchy
Other DBs
CAS: 114-86-3
PubChem: 96025038
ChEBI: 8064
ChEMBL: CHEMBL170988
DrugBank: DB00914
PDB-CCD: 8CV[PDBj]
LigandBox: D08351
NIKKAJI: J10.592I
LinkDB All DBs
KCF data Show

ATOM        15
            1   C8y C    21.5600  -15.4700
            2   C1b C    20.3700  -14.7700
            3   C8x C    21.5600  -16.8700
            4   C8x C    22.8200  -14.7700
            5   C1b C    19.1100  -15.4700
            6   C8x C    22.8200  -17.5700
            7   C8x C    24.0800  -15.4700
            8   N1b N    17.9900  -14.7700
            9   C8x C    24.0800  -16.8700
            10  C2c C    16.8000  -15.4700
            11  N1b N    15.5400  -14.7700
            12  N2a N    16.8000  -16.8700
            13  C2c C    14.3500  -15.4700
            14  N1a N    13.1600  -14.7700
            15  N2a N    14.3500  -16.8700
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     6   9 2
            9     8  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 2
            15    7   9 1

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