KEGG   DRUG: PrasteroneHelp
Entry
D08409                      Drug                                   

Name
Prasterone (USAN/INN);
Biolaif (TN)
Product
Formula
C19H28O2
Exact mass
288.2089
Mol weight
288.4244
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01590  Androgen receptor agonist
  DG01605  Anabolic steroid
Remark
Same as: C01227
ATC code: A14AA07 G03XX01
Chemical structure group: DG00141
Product (DG00141): D08409<US> D01616<JP>
Efficacy
Accelerator (cervical ripening), Androgen receptor agonist
Comment
Androstan derivative
Target
NR3C4 (AR) [HSA:367] [KO:K08557]
NR3A (ESR) [HSA:2099 2100] [KO:K08550 K08551]
  Pathway
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A14 ANABOLIC AGENTS FOR SYSTEMIC USE
   A14A ANABOLIC STEROIDS
    A14AA Androstan derivatives
     A14AA07 Prasterone
      D08409  Prasterone (USAN/INN) <US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
    G03XX Other sex hormones and modulators of the genital system
     G03XX01 Prasterone
      D08409  Prasterone (USAN/INN) <US>
USP drug classification [BR:br08302]
 Sexual Disorder Agents
  Prasterone
   D08409  Prasterone (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    NR3A (ESR)
     D08409  Prasterone (USAN/INN) <US>
   3-Ketosteroid receptor
    NR3C4 (AR)
     D08409  Prasterone (USAN/INN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08409
BRITE hierarchy
Other DBs
CAS: 53-43-0
PubChem: 96025095
ChEBI: 28689
ChEMBL: CHEMBL309821 CHEMBL363554 CHEMBL90593
PDB-CCD: AND[PDBj]
LigandBox: D08409
NIKKAJI: J4.147E
LinkDB All DBs
KCF data Show

ATOM        21
            1   C1y C    25.3400  -18.9700
            2   C1y C    24.1500  -18.3400
            3   C1y C    26.4600  -18.2700
            4   C1x C    25.3400  -20.3700
            5   C1z C    22.9600  -18.9700
            6   C1x C    24.1500  -16.9400
            7   C1z C    26.5300  -16.9400
            8   C1x C    28.8400  -18.2700
            9   C2x C    24.1500  -21.0000
            10  C2y C    22.9600  -20.3000
            11  C1x C    21.8400  -18.3400
            12  C1a C    23.0300  -17.5000
            13  C1x C    25.3400  -16.2400
            14  C5x C    27.6500  -16.2400
            15  C1a C    26.5300  -15.2600
            16  C1x C    28.8400  -16.9400
            17  C1x C    21.8400  -21.0000
            18  C1x C    20.6500  -18.9700
            19  O5x O    27.6500  -14.9100
            20  C1y C    20.6500  -20.3000
            21  O1a O    19.5300  -21.0000
BOND        24
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    7  15 1 #Up
            15    8  16 1
            16   10  17 1
            17   11  18 1
            18   14  19 2
            19   17  20 1
            20   20  21 1 #Up
            21    7  13 1
            22    9  10 2
            23   14  16 1
            24   18  20 1

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