KEGG   DRUG: PravastatinHelp
Entry
D08410                      Drug                                   

Name
Pravastatin (INN);
Pravator (TN)
Formula
C23H36O7
Exact mass
424.2461
Mol weight
424.5277
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Enzyme substrate
 DG01633  CYP3A substrate
Transporter substrate
 DG01665  ABCB1(P-GP) substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Same as: C01844
ATC code: C10AA03
Chemical structure group: DG00353
Product (DG00353): D00893<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Transporter: ABCC2 [HSA:1244], SLCO1B1 [HSA:10599], SLCO2B1 [HSA:11309]
Interaction
Drug interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA03 Pravastatin
      D08410  Pravastatin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pravastatin
    D08410  Pravastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D08410  Pravastatin (INN)
BRITE hierarchy
Other DBs
CAS: 81093-37-0
PubChem: 96025096
ChEBI: 63618
ChEMBL: CHEMBL1144
DrugBank: DB00175
LigandBox: D08410
NIKKAJI: J139.432K
LinkDB All DBs
KCF data Show

ATOM        30
            1   C1y C    19.2220  -19.6458
            2   C1y C    20.4805  -18.9466
            3   C1y C    18.0333  -18.9466
            4   C2y C    19.2220  -21.0442
            5   C1y C    21.7392  -19.6458
            6   C1b C    20.4805  -17.5481
            7   C1x C    16.8447  -19.6458
            8   O7a O    18.1032  -17.5481
            9   C2x C    18.0333  -21.7434
            10  C2x C    20.4805  -21.7434
            11  C2x C    21.7391  -21.0442
            12  C1a C    22.9278  -18.9466
            13  C1b C    21.6692  -16.7790
            14  C1y C    16.8447  -21.0442
            15  C7a C    16.8447  -16.8489
            16  C1c C    21.6692  -15.4505
            17  O1a O    15.6560  -21.7434
            18  C1c C    15.5162  -17.4782
            19  O6a O    16.8447  -15.4505
            20  C1b C    22.8578  -14.7513
            21  O1a O    20.4805  -14.7513
            22  C1b C    14.3275  -16.7790
            23  C1a C    15.5162  -18.8766
            24  C1c C    22.8578  -13.3529
            25  C1a C    13.1389  -17.4782
            26  C1b C    21.5993  -12.6537
            27  O1a O    24.0465  -12.6537
            28  C6a C    21.5992  -11.2553
            29  O6a O    22.8578  -10.6260
            30  O6a O    20.4106  -10.5561
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1 #Down
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    8  15 1
            15   13  16 1
            16   14  17 1 #Up
            17   15  18 1
            18   15  19 2
            19   16  20 1
            20   16  21 1 #Up
            21   18  22 1
            22   18  23 1 #Up
            23   20  24 1
            24   22  25 1
            25   24  26 1
            26   24  27 1 #Down
            27   26  28 1
            28   28  29 1
            29   28  30 2
            30    9  14 1
            31   10  11 2

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