| Entry |
|
|---|
| Name |
Pravastatin (INN);
Pravator (TN) |
|---|
| Formula |
C23H36O7
|
|---|
| Exact mass |
424.2461
|
|---|
| Mol weight |
424.53
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Transporter substrate
DG02861 ABCC2 substrate
DG02856 SLCO1B1 substrate
DG02933 SLCO2B1 substrate
|
|---|
| Remark |
| Product (DG00353): | D00893<JP/US> |
|
|---|
| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
|---|
| Metabolism |
Transporter: ABCC2 [HSA: 1244], SLCO1B1 [HSA: 10599], SLCO2B1 [HSA: 11309]
|
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| Interaction |
|
|---|
| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA03 Pravastatin
D08410 Pravastatin (INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00353 Pravastatin
D08410 Pravastatin
Transporter substrate
DG02861 ABCC2 substrate
DG00353 Pravastatin
D08410 Pravastatin
DG02856 SLCO1B1 substrate
DG00353 Pravastatin
D08410 Pravastatin
DG02933 SLCO2B1 substrate
DG00353 Pravastatin
D08410 Pravastatin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D08410 Pravastatin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08410
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00353 Pravastatin
Transporter substrate
DG02861 ABCC2 substrate
DG00353 Pravastatin
DG02856 SLCO1B1 substrate
DG00353 Pravastatin
DG02933 SLCO2B1 substrate
DG00353 Pravastatin
|
|---|
| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 30
1 C1y C 19.2220 -19.6458
2 C1y C 20.4805 -18.9466
3 C1y C 18.0333 -18.9466
4 C2y C 19.2220 -21.0442
5 C1y C 21.7392 -19.6458
6 C1b C 20.4805 -17.5481
7 C1x C 16.8447 -19.6458
8 O7a O 18.1032 -17.5481
9 C2x C 18.0333 -21.7434
10 C2x C 20.4805 -21.7434
11 C2x C 21.7391 -21.0442
12 C1a C 22.9278 -18.9466
13 C1b C 21.6692 -16.7790
14 C1y C 16.8447 -21.0442
15 C7a C 16.8447 -16.8489
16 C1c C 21.6692 -15.4505
17 O1a O 15.6560 -21.7434
18 C1c C 15.5162 -17.4782
19 O6a O 16.8447 -15.4505
20 C1b C 22.8578 -14.7513
21 O1a O 20.4805 -14.7513
22 C1b C 14.3275 -16.7790
23 C1a C 15.5162 -18.8766
24 C1c C 22.8578 -13.3529
25 C1a C 13.1389 -17.4782
26 C1b C 21.5993 -12.6537
27 O1a O 24.0465 -12.6537
28 C6a C 21.5992 -11.2553
29 O6a O 22.8578 -10.6260
30 O6a O 20.4106 -10.5561
BOND 31
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1 #Up
6 3 7 1
7 3 8 1 #Down
8 4 9 2
9 4 10 1
10 5 11 1
11 5 12 1 #Up
12 6 13 1
13 7 14 1
14 8 15 1
15 13 16 1
16 14 17 1 #Up
17 15 18 1
18 15 19 2
19 16 20 1
20 16 21 1 #Up
21 18 22 1
22 18 23 1 #Up
23 20 24 1
24 22 25 1
25 24 26 1
26 24 27 1 #Down
27 26 28 1
28 28 29 1
29 28 30 2
30 9 14 1
31 10 11 2
|
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